NATURE AND THE NATURE RESEARCH JOURNALS PRESS RELEASE
For papers that will be published online on 24 September 2006
This press release is copyrighted to the Nature journals mentioned below.
This press release contains:
* Summaries of newsworthy papers:
Drug and gene therapies get synchronized - Nature Materials
* Mention of papers to be published at the same time with the same embargo
* Geographical listing of authors
PDFs of all the papers mentioned on this release can be found in the relevant journal’s section of http://press.nature.com. Press contacts for the Nature journals are listed at the end of this release.
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******************** NATURE MATERIALS ************************** (<http://www.nature.com/naturematerials>)
[1] Drug and gene therapies get synchronized
DOI: 10.1038/nmat1737
Cancer can be tackled with a combination of drug and genetic therapies, such that the effectiveness of the individual treatments are enhanced, as shown by Yi-Yan Yang and colleagues in the October issue of Nature Materials. Beyond the promise for a more effective cure, achieving this synergistic effect also means that the dosage of anticancer treatments could be reduced.
The authors used biodegradable nanoparticles made from a polymer that has both a water-loving side and an oil-loving side. When placed in a water solution the polymer spontaneously forms nanoparticles in which the oil-loving part hides in the core and the water-loving part lines the outside shell. If an oil-loving drug is present in the solution, it will be incorporated in the core. In contrast, the shell can be used to bind DNA or RNA.
The researchers loaded the nanoparticles with a potent anticancer drug and therapeutic gene, and injected them in mouse tumours, and observed a significantly slower growth rate in the tumour.
Author contact:
Yi-Yan Yang (Institute of Bioengineering and Nanotechnology, The Nanos, Singapore)
Tel: +65 68247106; E-mail: [email protected]
Other papers from Nature Materials to be published online at the same time and with the same embargo:
[2] Electrical control of Förster energy transfer
DOI: 10.1038/nmat1738
[3] Enzyme-catalysed assembly of DNA hydrogel
DOI: 10.1038/nmat1741
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Items from other Nature journals to be published online at the same time and with the same embargo: Nature (<http://www.nature.com/nature>)
[4] Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation
DOI: 10.1038/nature05198
NATURE CHEMICAL BIOLOGY (http://www.nature.com/nchembio <http://www.nature.com/natureneuroscience>)
[5] Nitric oxide activates TRP channels by cysteine S-nitrosylation
DOI: 10.1038/nchembio821
Nature PHYSICS (http://www.nature.com/naturephysics <http://www.nature.com/naturematerials>)
[6] Measurement of the quantum capacitance of interacting electrons in carbon nanotubes
DOI: 10.1038/nphys412
[7] GeV electron beams from a centimetre-scale accelerator
DOI: 10.1038/nphys418
[8] Preparation of a quantum state with one molecule at each site of an optical lattice
DOI: 10.1038/nphys415
[9] Observation of subnanometre-high surface topography with X-ray reflection phase-contrast microscopy
DOI: 10.1038/nphys419
[10] Radiofrequency-dressed-state potentials for neutral atoms
DOI: 10.1038/nphys420
Nature MEDICINE (<http://www.nature.com/naturemedicine>)
[11] Targeting of CD44 eradicates human acute myeloid leukemic stem cells
DOI: 10.1038/nm1483
[12] Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells
DOI: 10.1038/nm1489
[13] LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
DOI: 10.1038/nm1484
[14] Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
DOI: 10.1038/nm1475
Nature BIOTECHNOLOGY (http://www.nature.com/naturebiotechnolgy)
[15] Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities
DOI: 10.1038/nbt1246
[16] Metagenomic analysis of two enhanced biological phosphorus removal (EBPR) sludge communities
DOI: 10.1038/nbt1247
NATURE GENETICS (<http://www.nature.com/naturegenetics>)
[17] A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
DOI: 10.1038/ng1885
[18] Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants
DOI: 10.1038/ng1888
[19] A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
DOI: 10.1038/ng1890
Nature NEUROSCIENCE (<http://www.nature.com/natureneuroscience>)
[20] A human parietal face area contains aligned head-centered visual and tactile maps
DOI: 10.1038/nn1777
[21] NMDA receptors are critical for unleashing consolidated auditory fear memories
DOI: 10.1038/nn1778
Nature IMMUNOLOGY (<http://www.nature.com/natureimmunology>)
[22] Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45
DOI: 10.1038/ni1390
[23] Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
DOI: 10.1038/ni1391
NATURE CELL BIOLOGY (<http://www.nature.com/naturecellbiology>)
[24] Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription
DOI: 10.1038/ncb1483
[25] Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
DOI: 10.1038/ncb1482
[26] Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo
DOI: 10.1038/ncb1476
[27] Self-organization of interphase microtubule arrays in fission yeast
DOI: 10.1038/ncb1479
[28] Self-organization of microtubule bundles in anucleate fission yeast cells
DOI: 10.1038/ncb1480
[29] Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis
DOI: 10.1038/ncb1475
Nature STRUCTURAL & MOLECULAR BIOLOGY (<http://www.nature.com/natstructmolbiol>)
[30] An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition
DOI: 10.1038/nsmb1149
[31] The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation
DOI: 10.1038/nsmb1145
[32] Structural analysis of kasugamycin inhibition of translation
DOI: 10.1038/nsmb1150
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GEOGRAPHICAL LISTING OF AUTHORS
The following list of places refers to the whereabouts of authors on the papers numbered in this release. The listing may be for an author's main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.
AUSTRALIA
Queensland: 16
AUSTRIA
Vienna: 10
CANADA:
Montreal: 17, 21
Toronto: 11
CHINA
Shanghai: 24
FRANCE
Paris: 11
GERMANY
Berlin: 31
Freiburg: 13
Garching: 8
Hamburg: 2
Hannover: 13
Heidelberg: 10
Kiel: 13
Munich: 2
GREECE
Heraklion: 10
JAPAN
Fukuoka-shi: 5
Kyoto: 5
Okazaki: 5
Tagajo-shi:
Tokyo: 5, 7, 31
Yokohama: 31
SINGAPORE
Sinagpore: 2
SPAIN
Sevilla: 28
SWITZERLAND
Bern: 25
Geneva: 25
THE NETHERLANDS:
Amsterdam: 22
Utrecht: 17
UNITED KINGDOM
Belfast: 19
Dundee: 29
Cambridge: 17, 29
Edinburgh: 29
Hertfordshire: 32
London: 17, 23, 27, 28
Newcastle: 19
Oxford: 7, 17
UNITED STATES OF AMERICA
Alabama :
Birmingham : 26
California
Berkeley: 2, 7, 31
La Jolla: 17, 20,
San Francisco: 32
Walnut Creek: 16
Yorktown Heights: 16
Georgia
Athens: 32
Maryland
College Park: 15
Frederick: 17
Massachusetts
Boston: 12, 15, 17, 18
Cambridge: 15, 17
Waltham:15
Nevada:
Reno: 7
New York
Ithaca: 3, 6
New York: 27
Ohio:
Oxford: 32
Texas:
Dallas: 30
Houston: 14, 24
Utah:
Salt Lake City: 2
Wisconsin:
Madison: 16
PRESS CONTACTS…
For media inquiries relating to embargo policy for all the Nature Research Journals:
Helen Jamison (Nature London)
Tel: +44 20 7843 4658; E-mail: [email protected]
Ruth Francis (Senior Press Officer, Nature, London)
Tel: +44 20 7843 4562; E-mail: [email protected]
For media inquiries relating to editorial content/policy for the Nature Research Journals, please contact the journals individually:
Nature Biotechnology (New York)
Peter Hare
Tel: +1 212 726 9284; E-mail: [email protected]
Nature Cell Biology (London)
Bernd Pulverer
Tel: +44 20 7843 4892; E-mail: [email protected]
Nature Chemical Biology (Boston)
Andrea Garvey
Tel: +1 617 475 9241, E-mail: [email protected]
Nature Genetics (New York)
Alan Packer
Tel: +1 212 726 9277; E-mail: [email protected]
Nature Immunology (New York)
Laurie Dempsey
Tel: +1 212 726 9372; E-mail: [email protected]
Nature Materials (London)
Maria Bellantone
Tel: +44 20 7843 4556; E-mail: [email protected]
Nature Medicine (New York)
Juan Carlos Lopez
Tel: +1 212 726 9325; E-mail: [email protected]
Nature Neuroscience (New York)
Sandra Aamodt (based in California)
Tel: +1 530 795 3256; E-mail: [email protected]
Nature Physics (London)
Alison Wright
Tel: +44 20 7843 4555; E-mail: [email protected]
Nature Structural & Molecular Biology (New York)
Michelle Montoya
Tel: +1 212 726 9326; E-mail: [email protected]
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