PRESS RELEASE FROM NATURE CLINICAL PRACTICE
GASTROENTEROLOGY & HEPATOLOGY
This press release is copyrighted to Nature Clinical Practice Gastroenterology & Hepatology.
Solely for the purpose of soliciting informed comment on this paper, you may show it to independent specialists - but you must ensure in advance that they understand and accept the embargo conditions.
Warning: This document, and the Nature Clinical Practice paper to which it refers, may contain information that is price sensitive (as legally defined, for example, in the UK Criminal Justice Act 1993 Part V) with respect to publicly quoted companies. Anyone dealing in securities using information contained in this document or in advanced copies of Nature’s content may be guilty of insider trading under the US Securities Exchange Act of 1934.
PLEASE CITE NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE AS THE SOURCE OF THE FOLLOWING ITEM. IF PUBLISHING ONLINE, PLEASE CARRY A HYPERLINK TO THE JOURNAL'S SITE: http://www.nature.com/ncpgasthep
Recommendations help identify patients suitable for NSAID treatment
Recommendations published in the October issue of Nature Clinical Practice Gastroenterology & Hepatology should help physicians to identify quickly whether or not a patient is suitable for treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). Francis Chan recommends NSAID use for patients based on their level of risk of encountering gastrointestinal or cardiovascular problems.
NSAIDs include aspirin and ibuprofen; they can reduce pain, fever and inflammation. They can be prescribed to patients with acute pain conditions such as bone cancer, or inflammation, for example arthritis. NSAID use is associated with a number of serious upper and lower gastrointestinal complications, including bleeding, perforation, and obstruction. In addition, certain NSAIDs can cause heart attacks.
Recognizing that many NSAID-related complications are predictable and preventable, Chan has reviewed the literature and produced some simple, practical recommendations to help physicians evaluate both the gastrointestinal and cardiovascular risks of individual patients in the clinic. With this information, the physician can identify who should and who should not receive NSAIDs. The recommendations also offer guidance on what kind of gastroprotective agents should be given alongside NSAIDs in patients deemed suitable for treatment.
Although research into the safety of NSAIDs continues, these recommendations provide a quick, clinically applicable means for physicians to harness the clinical benefits of NSAIDs in suitable patients, while helping them to avoid potentially fatal complications in patients for whom the risk of adverse effects is judged unacceptably high.
Francis KL Chan (The Chinese University of Hong Kong, Hong Kong)
Tel: +852 2632 3126; Email [email protected]
Natalie Wilson (Senior Editor, Nature Clinical Practice Gastroenterology & Hepatology)
Tel: +44 020 7843 4821, Email [email protected]
The Nature Clinical Practice journals
The first four journals launched in November 2004 and a further four in November 2005. This is NPG's most extensive launch programme and the Nature Clinical Practice series is due to extend to 15 titles over the next few years.
Each month the journals filter original research in their field, highlighting the most important research articles, then explaining how the research affects patients' treatments. Content also includes editorial and opinion pieces, highlights from the current literature, commentaries on the application of recent research to practical patient care, thorough reviews, and in-depth case studies.
For North America and Canada
Katie McGoldrick, Nature Washington
Tel: +1 202 737 2355; E-mail: [email protected]
For Japan, Korea, China, Singapore and Taiwan
Itsumi Kitahara, Nature Tokyo
Tel: +81 3 3267 8751; E-mail: [email protected]
For the UK/Europe/other countries not listed above
Ruth Francis, Nature London
Tel: +44 20 7843 4562; E-mail [email protected]
About Nature Publishing Group
Nature Publishing Group (NPG) is a division of Macmillan Publishers Ltd, dedicated to serving the academic, professional scientific and medical communities. NPG's flagship title, Nature, was first published in 1869. Other publications include Nature research journals, Nature Reviews, Nature Clinical Practice and a range of prestigious academic journals including society-owned publications. NPG also provides news content through [email protected] and scientific career information through Naturejobs.
NPG is a global company with headquarters in London and offices in New York, San Francisco, Washington DC, Boston, Tokyo, Paris, Munich, Hong Kong, Melbourne, Delhi, Mexico City and Basingstoke. For more information, please go to <www.nature.com>.