RESEARCH TITLE:
LAYERED DOUBLE HYDROXIDES AS A CONTROLLED-RELEASE FORMULATION FOR DRUG DELIVERY SYSTEM
RESEARCHERS:
(a) Yamin Yasin
(a) Noorziana Salehuddin
(b) Mohd Zobir Hussein
(a) International Education Centre, Universiti Teknologi MARA
Kampus Seksyen 17, 40200 Shah Alam, Selangor
(b) Chemistry Department, Faculty of Science, Universiti Putra
Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
The continuous development of new drug delivery systems is driven by the need to maximize therapeutic activity while minimizing negative side effects. Layered double hydroxide is one class of drug delivery vehicle which can accommodate polar organic compounds between their layers and form a variety of intercalated compounds. Because the release of drugs is potentially controllable, these new materials have a great potential as a delivery host in the pharmaceutical field in preparing a controlled release formulation.
RESEARCH TITLE:
BETULINIC ACID DERIVATIVES; POTENTIAL ANTI-CANCER AGENTS
RESEARCHERS:
(a) Yamin Yasin
(b) Faujan Ahmad
(a) International Education Centre, Universiti Teknologi MARA
Kampus Seksyen 17, 40200 Shah Alam, Selangor
(b) Chemistry Department, Faculty of Science, Universiti Putra Malaysia
43400 UPM Serdang, Selangor
ABSTRACT
Betulinic acid is a natural product isolated from several genuses of higher plants. Betulinic acid is virtually non-toxic with IC50 > 20 g/ml to a wide range of cultured human cells and a selective cyototoxicity towards human melanoma cells, tumor cell lines and human leukemia. An examination of the structure of betulinic acid revealed that it contains three carbon centers on which functional groups can be introduced or modified. By performing specific modification at these three positions, potentially important derivatives can be produced. Betulinic acid may have different properties as compared to their acid counterpart. It could be absorbed more easily and thus are more desirable. Through a series of reactions at these three positions, a number of potentially derivatives which may improve the selective toxicity profile or reduce general toxic effects can be achieved.
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