Journal of Plant Biochemistry and Biotechnology
Year : 2005, Volume : 14, Issue : 2
Print ISSN : 0971-7811.
Plant Transformation Vectors Having Street Rabies Virus (Indian Strain) Glycoprotein Gene
Authors: Agrawal Sweta, Shasany A K, Khanuja S P S*
Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow 226 015, India
*Corresponding author. E-mail: [email protected]
Abstract
Rabies, a serious health hazard, affects central nervous system of mammals and is caused by rabies virus. The viral glycoprotein forms the external surface of virus and is the most antigenic protein. Hence the rabies glycoprotein is an ideal candidate for use in the construction of a subunit marked vaccine. With the idea to substitute the total inactivated virus with G protein in the production of vaccine, the study was undertaken to clone the full-length glycoprotein gene under the control of various constitutive and expression promoters for its expression in bacterial background and its further cloning for plant transformation.
