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For papers that will be published online on 18 December 2005
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* Susceptibility to SARS infection - Nature Genetics
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*******************************NATURE GENETICS******************************
(<http://www.nature.com/naturegenetics>)
[11] Susceptibility to SARS infection
DOI: 10.1038/ng1698
A new study in the January issue of Nature Genetics reports that individuals
with particular combinations of genetic variants are less susceptible to
infection by the SARS virus. SARS is an acute respiratory disease resulting
from infection of a coronavirus, SARS-CoV.
The authors examined 285 individuals with SARS infection from the
2003 outbreak in Hong Kong, as well as 3 control groups of individuals not
infected with SARS. The study found that those individuals with particular
combinations of repeats in the extracellular region of a receptor molecule
known as L-SIGN, previously shown to bind to the SARS-CoV, show a reduced
risk of infection. L-SIGN has also previously been shown to bind the
viruses HIV and SIV, and is involved with mediating infection of these
viruses, as well as the bacterium M. tuberculosis. This identification
provides insight into the mechanism by which SARS-CoV infects a human host,
and may help to understand better the nature of the SARS epidemic within
these regions.
Author Contact:
Chen-Lung S Lin (The University of Hong Kong, China)
Tel: +852 2855 3387, E-mail: [email protected]
Other papers from Nature Genetics to be published online at the same time
and with the same embargo:
[12] Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic
exocrine dysfunction
DOI: 10.1038/ng1708
[13] APP locus duplication causes autosomal dominant early-onset Alzheimer
disease with cerebral amyloid angiopathy
DOI: 10.1038/ng1718
[14] Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine
thyroid tumor
DOI: 10.1038/ng1703
[15] Genome-wide transcription analyses in rice using tiling microarrays
DOI: 10.1038/ng1704
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