16 years of regeneration for the newt lens

Summaries of newsworthy papers: 16 years of regeneration for the newt lens; A new cellular role for TorsinA

This press release contains:

- Summaries of newsworthy papers:

16 years of regeneration for the newt lens

A new cellular role for TorsinA

- Mention of papers to be published at the same time with the same embargo

- Geographical listing of authors

Editorial contacts: While the best contacts for stories will always be the authors themselves, in some cases the Nature editor who handled the paper will be available for comment if an author is unobtainable. Editors are contactable via Ruth Francis on +44 20 7843 4562. Feel free to get in touch with Nature's press contacts in London, Washington and Tokyo (as listed at the end of this release) with any general editorial inquiry.

Warning: This document, and the Nature Communications papers to which it refers, may contain information that is price sensitive (as legally defined, for example, in the UK Criminal Justice Act 1993 Part V) with respect to publicly quoted companies. Anyone dealing in securities using information contained in this document or in advanced copies of Nature’s content may be guilty of insider trading under the US Securities Exchange Act of 1934.

The Nature journals press site is at http://press.nature.com

PICTURES: While we are happy for images from Nature to be reproduced for the purposes of contemporaneous news reporting, you must also seek permission from the copyright holder (if named) or author of the research paper in question (if not).

HYPE: We take great care not to hype the papers mentioned on our press releases, but are sometimes accused of doing so. If you ever consider that a story has been hyped, please do not hesitate to contact us at [email protected], citing the specific example.

PLEASE CITE NATURE AND OUR WEBSITE www.nature.com/naturecommunications AS THE SOURCE OF THE FOLLOWING ITEMS. IF PUBLISHING ONLINE, PLEASE CARRY A HYPERLINK TO www.nature.com/naturecommunications

[1] 16 years of regeneration for the newt lens
DOI: 10.1038/ncomms1389

The lens of the Japanese newt, Cynops pyrrhogaster, can regenerate eighteen times over a sixteen year period, reports a study published in Nature Communications this week. These findings suggest that in this species of newt regeneration of the eye does not become less efficient over time or with age.

Panagiotis Tsonis and colleagues collected newts in 1994 and over time repeatedly removed the lens of their eyes, in a procedure termed a lensectomy. The experiment was performed eighteen times over a sixteen year period and they demonstrate that the lenses that regenerate after the 17th and 18th procedure have the same morphology as control newts and express lens genes at a similar level. Their findings reveal a new extended capacity for regeneration over a prolonged period of time.

CONTACT
Panagiotis Tsonis (University of Dayton, OH, USA)
Tel: +1 937 229 2579; E-mail: [email protected]

[2] A new cellular role for TorsinA
DOI: 10.1038/ncomms1383

TorsinA, which is mutated in early onset torsion dystonia, is found to assist in the degradation of proteins in a part of the cell called the endoplasmic reticulum. These findings, published in Nature Communications this week, suggest that increased endoplasmic reticulum stress in the neurons of these patients may contribute to the disease.

Xandra Breakefield and colleagues demonstrate a new cellular role for TorsinA in the endoplasmic reticulum and show that TorsinA can protect against endoplasmic reticulum stress in nematode worms that carry a mutant version of a certain cystic fibrosis regulator protein. They also find that fibroblasts from patients with early onset torsion dystonia are more sensitive to pharmacological agents that cause endoplasmic reticulum stress and are less able to degrade the mutant version of the cystic fibrosis regulator protein.

These findings may prompt study of endoplasmic reticulum stress in the neurons of patients with early onset torsion dystonia with the potential of preventing stress in this cell within the patients.

CONTACT
Xandra Breakefield (Massachusetts General Hospital, Charlestown, MA, USA)
Tel: +1 617 726 5728; E-mail: [email protected]

Papers to go live at the same time

[3] Fractional quantum Hall effect in the absence of Landau levels
DOI: 10.1038/ncomms1380

[4] The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signaling programme
DOI: 10.1038/ncomms1381

[5] Crystal structure of the human thioredoxin reductase - thioredoxin complex
DOI: 10.1038/ncomms1382

[6] Confined Propagation of Covalent Chemical reactions on Single-Walled Carbon Nanotubes
DOI: 10.1038/ncomms1384

[7] Calcium modulates force sensing by the von Willebrand Factor A2 domain
DOI: 10.1038/ncomms1385

[8] Cascaded Logic Gates in Nanophotonic Plasmon Networks
DOI: 10.1038/ncomms1388

[9] Mechanism of 150-Cavity Formation in Influenza Neuraminidase
DOI: 10.1038/ncomms1390

[10] Chemotactic anti-viral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells
DOI: 10.1038/ncomms1391

[11] A photoconvertible fluorescent reporter to track chaperone-mediated autophagy
DOI: 10.1038/ncomms1393

[12] Fermi surface dichotomy of the superconducting gap and pseudogap in underdoped pnictides
DOI: 10.1038/ncomms1394

GEOGRAPHICAL LISTING OF AUTHORS…

The following list of places refers to the whereabouts of authors on the papers numbered in this release. For example, London: 4 - this means that on paper number four, there will be at least one author affiliated to an institute or company in London. The listing may be for an author's main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.

CHINA
Beijing: 8, 12
Nanjing: 3
Xiamen: 6
Xi’an: 6

GERMANY
Giessen: 5
Heidelberg: 5
Lübeck: 2

JAPAN
Aichi: 1
Tokyo: 2
Kawaguchi: 12
Kumamoto: 1
Sendai: 12

SPAIN
Barcelona: 11

SWEDEN
Göteborg: 8
Lund: 8

SWITZERLAND
Zurich: 10

THE NETHERLANDS
Amsterdam: 7
Utrecht: 7

UNITED STATES OF AMERICA
Alabama
Birmingham: 2
California
Berkley: 12
Irvine: 9
La Jolla: 1, 9
Northridge: 3
Santa Barbara: 3
Illinois
Evanston: 6
Massachusetts
Boston: 2
Chestnut Hill: 12
Maryland
Bethesda: 2
College Park: 3, 6
Frederick: 4
Maine
Scarborough: 4
Minnesota
Minneapolis: 4
New York
Bronx: 11
Ohio
Dayton: 1
Pennsylvania
Pittsburgh: 4

PRESS CONTACTS…

From North America and Canada
Neda Afsarmanesh, Nature New York
Tel: +1 212 726 9231; E-mail: [email protected]

From Japan, Korea, China, Singapore and Taiwan
Mika Nakano, Nature Tokyo
Tel: +81 3 3267 8751; E-mail: [email protected]

From the UK
Rachel Twinn, Nature, London
Tel: +44 20 7843 4658; E-mail: [email protected]

About Nature Publishing Group (NPG):

Nature Publishing Group (NPG) is a publisher of high impact scientific and medical information in print and online. NPG publishes journals, online databases and services across the life, physical, chemical and applied sciences and clinical medicine.

Focusing on the needs of scientists, Nature (founded in 1869) is the leading weekly, international scientific journal. In addition, for this audience, NPG publishes a range of Nature research journals and Nature Reviews journals, plus a range of prestigious academic journals including society-owned publications. Online, nature.com provides over 5 million visitors per month with access to NPG publications and online databases and services, including Nature News and NatureJobs plus access to Nature Network and Nature Education’s Scitable.com.

Scientific American is at the heart of NPG’s newly-formed consumer media division, meeting the needs of the general public. Founded in 1845, Scientific American is the oldest continuously published magazine in the US and the leading authoritative publication for science in the general media. Together with scientificamerican.com and 15 local language editions around the world it reaches over 3 million consumers and scientists. Other titles include Scientific American Mind and Spektrum der Wissenschaft in Germany.

Throughout all its businesses NPG is dedicated to serving the scientific and medical communities and the wider scientifically interested general public. Part of Macmillan Publishers Limited, NPG is a global company with principal offices in London, New York and Tokyo, and offices in cities worldwide including Boston, Buenos Aires, Delhi, Hong Kong, Madrid, Barcelona, Munich, Heidelberg, Basingstoke, Melbourne, Paris, San Francisco, Seoul and Washington DC. For more information, please go to www.nature.com.

Published: 12 Jul 2011

Contact details:

The Macmillan Building, 4 Crinan Street
London
N1 9XW
United Kingdom

+44 20 7833 4000
Country: 
News topics: 
Content type: 
Websites: 
Reference: 

Autophagy
Cell