16 years of regeneration for the newt lens

Summaries of newsworthy papers: 16 years of regeneration for the newt lens; A new cellular role for TorsinA

This press release contains:

- Summaries of newsworthy papers:

16 years of regeneration for the newt lens

A new cellular role for TorsinA

- Mention of papers to be published at the same time with the same embargo

- Geographical listing of authors

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[1] 16 years of regeneration for the newt lens
DOI: 10.1038/ncomms1389

The lens of the Japanese newt, Cynops pyrrhogaster, can regenerate eighteen times over a sixteen year period, reports a study published in Nature Communications this week. These findings suggest that in this species of newt regeneration of the eye does not become less efficient over time or with age.

Panagiotis Tsonis and colleagues collected newts in 1994 and over time repeatedly removed the lens of their eyes, in a procedure termed a lensectomy. The experiment was performed eighteen times over a sixteen year period and they demonstrate that the lenses that regenerate after the 17th and 18th procedure have the same morphology as control newts and express lens genes at a similar level. Their findings reveal a new extended capacity for regeneration over a prolonged period of time.

Panagiotis Tsonis (University of Dayton, OH, USA)
Tel: +1 937 229 2579; E-mail: [email protected]

[2] A new cellular role for TorsinA
DOI: 10.1038/ncomms1383

TorsinA, which is mutated in early onset torsion dystonia, is found to assist in the degradation of proteins in a part of the cell called the endoplasmic reticulum. These findings, published in Nature Communications this week, suggest that increased endoplasmic reticulum stress in the neurons of these patients may contribute to the disease.

Xandra Breakefield and colleagues demonstrate a new cellular role for TorsinA in the endoplasmic reticulum and show that TorsinA can protect against endoplasmic reticulum stress in nematode worms that carry a mutant version of a certain cystic fibrosis regulator protein. They also find that fibroblasts from patients with early onset torsion dystonia are more sensitive to pharmacological agents that cause endoplasmic reticulum stress and are less able to degrade the mutant version of the cystic fibrosis regulator protein.

These findings may prompt study of endoplasmic reticulum stress in the neurons of patients with early onset torsion dystonia with the potential of preventing stress in this cell within the patients.

Xandra Breakefield (Massachusetts General Hospital, Charlestown, MA, USA)
Tel: +1 617 726 5728; E-mail: [email protected]

Papers to go live at the same time

[3] Fractional quantum Hall effect in the absence of Landau levels
DOI: 10.1038/ncomms1380

[4] The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signaling programme
DOI: 10.1038/ncomms1381

[5] Crystal structure of the human thioredoxin reductase - thioredoxin complex
DOI: 10.1038/ncomms1382

[6] Confined Propagation of Covalent Chemical reactions on Single-Walled Carbon Nanotubes
DOI: 10.1038/ncomms1384

[7] Calcium modulates force sensing by the von Willebrand Factor A2 domain
DOI: 10.1038/ncomms1385

[8] Cascaded Logic Gates in Nanophotonic Plasmon Networks
DOI: 10.1038/ncomms1388

[9] Mechanism of 150-Cavity Formation in Influenza Neuraminidase
DOI: 10.1038/ncomms1390

[10] Chemotactic anti-viral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells
DOI: 10.1038/ncomms1391

[11] A photoconvertible fluorescent reporter to track chaperone-mediated autophagy
DOI: 10.1038/ncomms1393

[12] Fermi surface dichotomy of the superconducting gap and pseudogap in underdoped pnictides
DOI: 10.1038/ncomms1394


The following list of places refers to the whereabouts of authors on the papers numbered in this release. For example, London: 4 - this means that on paper number four, there will be at least one author affiliated to an institute or company in London. The listing may be for an author's main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.

Beijing: 8, 12
Nanjing: 3
Xiamen: 6
Xi’an: 6

Giessen: 5
Heidelberg: 5
Lübeck: 2

Aichi: 1
Tokyo: 2
Kawaguchi: 12
Kumamoto: 1
Sendai: 12

Barcelona: 11

Göteborg: 8
Lund: 8

Zurich: 10

Amsterdam: 7
Utrecht: 7

Birmingham: 2
Berkley: 12
Irvine: 9
La Jolla: 1, 9
Northridge: 3
Santa Barbara: 3
Evanston: 6
Boston: 2
Chestnut Hill: 12
Bethesda: 2
College Park: 3, 6
Frederick: 4
Scarborough: 4
Minneapolis: 4
New York
Bronx: 11
Dayton: 1
Pittsburgh: 4


From North America and Canada
Neda Afsarmanesh, Nature New York
Tel: +1 212 726 9231; E-mail: [email protected]

From Japan, Korea, China, Singapore and Taiwan
Mika Nakano, Nature Tokyo
Tel: +81 3 3267 8751; E-mail: [email protected]

From the UK
Rachel Twinn, Nature, London
Tel: +44 20 7843 4658; E-mail: [email protected]

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Published: 12 Jul 2011

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