This press release contains:
---Summaries of newsworthy papers:
Medicine: A new receptor for the hepatitis C virus
Immunology: Misguided macrophages
---Mention of papers to be published at the same time with the same embargo
---Geographical listing of authors
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[1] Medicine: A new receptor for the hepatitis C virus
The identification of a new receptor for the hepatitis C virus (HCV) is reported in an article published online this week in Nature Medicine. The Niemann-Pick C1–like 1 (NPC1L1) cholesterol absorption receptor has the potential to become a therapeutic target for the virus.
HCV is a leading cause of liver disease, with around 170 million people infected worldwide. Current treatment options have low efficacy and serious side effects, making it necessary to develop more effective antivirals. Reasoning that viral entry into cells represents a potential target for antiviral intervention, Susan Uprichard and her colleagues found that the NPC1L1 cholesterol uptake receptor is an HCV entry factor amenable to therapeutic intervention. The team found that reducing the expression or blocking of NPC1L1 impaired HCV infection in human cells In addition, the clinically available NPC1L1 antagonist ezetimibe potently blocked HCV uptake and inhibited HCV infection in mice with human liver grafts.
The availability of a drug that targets NPC1L1 already approved for use in humans may accelerate the translation of this finding to the clinical setting.
Author contact:
Susan Uprichard (University of Illinois, Chicago, IL, USA)
Tel: +1 312 355 3784; E-mail: [email protected]
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[2] Immunology: Misguided macrophages
Why macrophages stay in artery plaques, one of the key causative elements of atherosclerosis, is explained this week in an article published in Nature Immunology. These results suggest that interfering with macrophage migratory signals could be important for progression of atherosclerosis and may provide clues for treatment.
Kathryn Moore and colleagues found that Netrin-1, a molecule normally used by the body to guide the movement of neurons, was also released by macrophages activated in the plaque of atherosclerotic mice. Netrin-1 signaled macrophages to stop migrating in response to chemical cues and these cells thus accumulated within the plaque. Genetically deleting Netrin-1 reduced atherosclerotic symptoms and resulted in fewer plaque-resident macrophages.
Author contact:
Kathryn J Moore (New York University Medical Center, NY, USA)
Tel: +1 212 263 9259; E-mail: [email protected]
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Items from other Nature journals to be published online at the same time and with the same embargo:
Nature
[3] Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
DOI: 10.1038/nature10728
[4] X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
DOI: 10.1038/nature10737
[5] Structure of the carboxy-terminal region of a KCNH Channel
DOI: 10.1038/nature10735
[6] Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain
DOI: 10.1038/nature10742
[7] Cysteinyl leukotriene type I receptor desensitization sustains Ca21-dependent gene expression
DOI: 10.1038/nature10731
[8] Evolution of increased complexity in a molecular machine
DOI: 10.1038/nature10724
NATURE CELL BIOLOGY (http://www.nature.com/naturecellbiology)
[9] Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation
DOI: 10.1038/ncb2406
[10] Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation
of eIF2B
DOI: 10.1038/ncb2408
NATURE CHEMICAL BIOLOGY (http://www.nature.com/nchembio)
[11] Disease-Specific Non-Reducing End Carbohydrate Biomarkers for Mucopolysaccharidoses
DOI: 10.1038/nchembio.766
[12] Timing Facilitated Site Transfer of an Enzyme on DNA
DOI: 10.1038/nchembio.764
[13] Oxysterols are allosteric activators of the oncoprotein Smoothened
DOI: 10.1038/nchembio.765
NATURE CHEMISTRY (http://www.nature.com/nchem)
[14] Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
DOI: 10.1038/nchem.1234
[15] Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor
DOI: 10.1038/nchem.1241
[16] Binary fluorous tagging enables the synthesis and separation of a 16-stereoisomer library of macrosphelides
DOI: 10.1038/nchem.1233
NATURE CLIMATE CHANGE (http://www.nature.com/nclimate)
[17] Continent-wide response of mountain vegetation to climate change
DOI: 10.1038/nclimate1329
[18] Changes in hail and flood risk in high-resolution simulations over the Colorado Mountains
DOI: 10.1038/nclimate1344
[19] Climate-regulation services of natural and agricultural ecoregions of the Americas
DOI: 10.1038/nclimate1346
[20] Differences in the climatic debts of birds and butterflies at a continental scale
DOI: 10.1038/nclimate1347
[21] Climate impacts on bird and plant communities from altered animal–plant interactions
DOI: 10.1038/nclimate1348
[22] Tension between reducing sea-level rise and global warming through solar radiation management
DOI: 10.1038/nclimate1351
NATURE GENETICS (http://www.nature.com/naturegenetics)
[23] De novo assembly and genotyping of variants using colored de Bruijn graphs
DOI: 10.1038/ng.1028
[24] Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint
DOI: 10.1038/ng.1039
[25] Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel
DOI: 10.1038/ng.1042
[26] Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
DOI: 10.1038/ng.1064
[27] Crh and Oprm1 mediate anxiety-related behaviour and social approach in a mouse model of MECP2 duplication syndrome
DOI: 10.1038/ng.1066
NATURE GEOSCIENCE (http://www.nature.com/ngeo)
[28] Impact of transient groundwater storage on the discharge of Himalayan rivers
DOI: 10.1038/ngeo1356
[29] Determining the natural length of the current interglacial
DOI: 10.1038/ngeo1358
[30] Life in the hydrated suboceanic mantle
DOI: 10.1038/ngeo1359
NATURE IMMUNOLOGY (http://www.nature.com/natureimmunology)
[31] NLRC4 inflammasomes in dendritic cells regulate effector function by memory CD8+ T cells
DOI: 10.1038/ni.2195
[32] Signaling via the kinase p38a programs dendritic cells to drive TH17 differentiation and autoimmune inflammation
DOI: 10.1038/ni.2207
NATURE MATERIALS (http://www.nature.com/naturematerials)
[33] Charged nanoparticles as supramolecular surfactants for controlling the growth and stability of microcrystals
DOI: 10.1038/nmat3202
[34] Metastable structures and isotope exchange reactions in polyoxometalate ions provide a molecular view of oxide dissolution
DOI: 10.1038/nmat3203
[35] Thermal conductivity of isotopically modified graphene
DOI: 10.1038/nmat3207
[36] A new class of doped nanobulk high-figure-of-merit thermoelectrics by scalable bottom-up assembly
DOI: 10.1038/nmat3213
[37] Destruction of the Kondo effect in cubic heavy-fermion compound Ce3Pd20Si6
DOI: 10.1038/nmat3214
Nature MEDICINE (http://www.nature.com/naturemedicine)
[38] A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20
DOI: 10.1038/nm.2596
[39] AICAR prevents heat induced sudden death in RyR1 mutant mice independent of AMPK activation
DOI: 10.1038/nm.2598
NATURE METHODS (http://www.nature.com/nmeth)
[40] Blotting protein complexes from native gels to electron microscopy grids
DOI: 10.1038/nmeth.1840
[41] Dual-objective STORM reveals three-dimensional filament organization in the actin cytoskeleton
DOI: 10.1038/nmeth.1841
[42] Fast two-photon in vivo imaging with three-dimensional random access scanning in large tissue volumes
DOI: 10.1038/nmeth.1851
NATURE NANOTECHNOLOGY (http://www.nature.com/nnano)
[43] Photoluminescence imaging of electronic-impurity-induced exciton quenching in single-walled carbon nanotubes
DOI:10.1038/nnano.2011.227
[44] Probing and repairing damaged surfaces with nanoparticle-containing microcapsules
DOI:10.1038/nnano.2011.235
Nature NEUROSCIENCE (http://www.nature.com/natureneuroscience)
[45] NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins
DOI: 10.1038/nn.2991
[46] Emergence of a "Visual Number Sense" in Hierarchical Generative Models
DOI: 10.1038/nn.2996
[47] Preferential Encoding of Visual Categories in Parietal Cortex Compared to Prefrontal Cortex
DOI: 10.1038/nn.3016
[48] SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance
DOI: 10.1038/nn.3022
[49] Mechanisms underlying cortical activity during value-guided choice
DOI: 10.1038/nn.3017
[50] Saccade-confounded image statistics explain visual crowding
DOI: 10.1038/nn.3021
NATURE PHOTONICS (http://www.nature.com/nphoton)
[51] Extremely efficient flexible organic light-emitting diodes with modified graphene anode
DOI: 10.1038/nphoton.2011.318
Nature PHYSICS (http://www.nature.com/naturephysics)
[52] Acceleration in the linear non-scaling fixed-field alternating-gradient accelerator EMMA
DOI: 10.1038/nphys2179
[53] Phonon-mediated superconductivity in graphene by lithium deposition
DOI: 10.1038/nphys2181
[54] Spin-half paramagnetism in graphene induced by point defects
DOI: 10.1038/nphys2183
[55] Sculpting oscillators with light within a nonlinear quantum fluid
DOI: 10.1038/nphys2182
Nature STRUCTURAL & MOLECULAR BIOLOGY (http://www.nature.com/natstructmolbiol)
[56] A conserved PUF–Ago–eEF1A complex attenuates translation elongation
DOI: 10.1038/nsmb.2214
[57] Chromodomains read the arginine code of post-translational targeting
DOI: 10.1038/nsmb.2196
[58] Dynein achieves processive motion using both stochastic and coordinated stepping
DOI: 10.1038/nsmb.2205
[59] Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2
DOI: 10.1038/nsmb.2212
[60] Structure of a KirBac potassium channel with an open bundle-crossing indicates a mechanism of channel gating
DOI: 10.1038/nsmb.2208
[61] Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance
DOI: 10.1038/nsmb.2209
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GEOGRAPHICAL LISTING OF AUTHORS
The following list of places refers to the whereabouts of authors on the papers numbered in this release. The listing may be for an author's main affiliation, or for a place where they are working temporarily. Please see the PDF of the paper for full details.
AUSTRALIA
Clayton: 52
Heidelberg: 31
Melbourne: 31
AUSTRIA
Innsbruck: 17
Vienna: 17, 25, 37
BRAZIL
Brasilia: 19
Manaus: 17
Minas Gerais: 2
Rio de Janeiro: 19
Vicosa: 19
CANADA:
Toronto: 61
Vancouver: 52
CHINA
Hefei: 24
Nanjing: 38
Xiamen: 35
CYPRUS
Nicosia: 17
FINLAND
Helsinki: 20, 54
FRANCE
Grenoble: 57
Montpellier: 20
Paris: 20, 30, 53, 60
Rennes: 28
Toulouse: 28
GEORGIA
Tsibili: 17
GERMANY
Berlin: 31
Bonn: 6
Freiburg: 28
Garching: 57
Gauting: 40
Halle: 20, 53
Heidelberg: 6, 26, 57
Martinsried: 40, 58
Munich: 14
Neuherberg: 57
Oberkochen: 40
GREECE
Chania: 17
HUNGARY
Budapest: 40, 42
ITALY
Bologna: 30
Busto Arsizio: 48
Genoa: 48
L’Aquila: 53
Milan: 61
Modena: 30
Padova: 46
Parma: 17
Pavia: 17
Pesche: 17
JAPAN
Hiroshima: 1
Osaka: 32, 38
Suita: 38
Tokyo: 37
NETHERLANDS
Beek-Ubbergen: 20
Nijmegen: 20, 31
The Hague: 20
Wageningen: 20
NORWAY
Bergen: 29
Trondheim: 17
ROMANIA
Cluj-Napoca: 17
SINGAPORE
Singapore: 61
SLOVAKIA
Bratislava: 17
SOUTH AFRICA
Auckland Park: 37
SOUTH KOREA
Gyeonggi-do: 51
Pohang: 51
Seoul: 35, 51
SPAIN
Barcelona: 20
Granada: 17
Granollers: 20
Jaca: 17
Solsona: 20
SWEDEN
Arvika: 17
Gothenburg: 17
Lund: 20
Solna: 6
Stockholm: 6
SWITZERLAND
Basel: 42
Chambesy: 17
Champex-Lac: 17
Epalinges: 31
Lausanne: 17
UNITED KINGDOM
Birmingham: 60
Bristol: 22
Cambridge: 29
Cardiff: 48
Daresbury: 52
Glasgow: 17
Lancaster: 52
Leicester: 3
Liverpool: 52
London: 23, 29, 32, 48, 49, 52
Manchester: 54
Norwich: 23
Oxford: 7, 23, 25, 49, 60
Oxon: 52
Penicuik: 17
Uxbridge: 52
Thetford: 20
Wallingford: 20
Wareham: 20
Warrington: 52
UNITED STATES OF AMERICA
Arizona
Tempe: 15, 31
California
Berkeley: 5, 14
Davis: 34
La Jolla: 9, 11, 50
Los Angeles: 25, 50, 58
Riverside: 35
San Diego: 11
Stanford: 9, 13, 24, 49
Colorado
Boulder: 18
Florida
Gainesville: 29
Georgia
Athens: 11
Illinois
Batavia: 52
Chicago: 1, 8, 25
Evanston: 33
Urbana: 19
Kansas
Manhattan: 25
Maryland
Baltimore: 12
Bethesda: 38
Frederick: 38
Massachusetts
Amherst: 44
Boston: 2, 27, 39, 58
Cambridge: 41
Woods Hole: 58
Michigan
Ann Arbor: 59
Minnesota
St Paul: 19
Missouri
St Louis: 13, 27
Montana
Missoula: 21
New Mexico
Los Alamos: 43
New York
Corning: 34
New York: 1, 2, 10, 52
Rochester: 39
Troy: 36
Oregon
Eugene: 8
Portland: 4
Pennsylvania
Hershey: 10
Pittsburgh: 16, 44
University Park: 22, 33
Tennessee
Memphis: 32
Texas
Austin: 35
Houston: 27, 37, 39
Richardson: 35
Washington
Seattle: 2, 5, 45
Wisconsin
Madison: 24, 56
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Tel: +44 20 7843 4658; E-mail: [email protected]
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For media inquiries relating to editorial content/policy for the Nature Research Journals, please contact the journals individually:
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Tel: +1 617 475 9241, E-mail: [email protected]
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Stuart Cantrill
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Tel: +44 20 7843 4531; E-mail: [email protected]
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Tel: +1 212 726 9325; E-mail: [email protected]
Nature Methods (New York)
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Tel: +1 212 726 9627; E-mail: [email protected]
Nature Nanotechnology (London)
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Tel: +44 20 7014 4019; Email: [email protected]
Nature Neuroscience (New York)
Kalyani Narasimhan
Tel: +1 212 726 9319; E-mail: [email protected]
Nature Photonics (Tokyo)
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Tel: +81 3 3267 8776; E-mail: [email protected]
Nature Physics (London)
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Tel: +44 20 7843 4555; E-mail: [email protected]
Nature Structural & Molecular Biology (New York)
Sabbi Lall
Tel: +1 212 726 9326; E-mail: [email protected]
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