University Malaya team publishes papers in Pharmocogenomics on reactions to antiepileptic and schizophrenia drugs

Malaysia, with its multi-ethnic population, is a perfect laboratory for scientists to look at how inherited differences in genes can affect the patient’s responses to medications. These genetic differences can be used to predict whether a medication will be effective for a particular person and to help prevent adverse drug reactions.

University of Malaya extends its congratulations to Prof. Datin Dr. Zahurin Bt Mohamed, Head of the Pharmacogenomics Laboratory in the Department of Pharmacology, Faculty of Medicine, University of Malaya for giving birth to “twin” papers in the current issue of the prestigious journal Pharmacogenomics. This is indeed a rare feat and a credit to the leadership of Prof. Zahurin and the hard work of the team.

Prof. Zahurin explains, “Pharmacogenomics is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) in attempts to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup”.

According to Prof. Zahurin, many drugs that are currently available are “one size fits all,” but they do not work the same way for everyone. It can be difficult to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions). “As a matter of fact,” said Prof. Zahurin, “adverse drug reactions are a significant cause of hospitalizations and deaths”.

Malaysia, being made up of a multi-ethnic population, makes a perfect laboratory for pharmacogenomics research to look into how inherited differences in genes can affect the patient’s responses to medications. These genetic differences can be used to predict whether a medication will be effective for a particular person and to help prevent adverse drug reactions.

ABOUT THE PHARMACOGENOMICS LABORATORY

The Pharmacogenomics Laboratory is supported by researchers from the pre-clinical and clinical departments, with over 20 postgraduate students, and has received funding of over RM3.5million over a period of 5 years from UM HIR MoE. It has successfully published over 17 papers in Tier 1 journals since 2011. The Tier 1 journals of high impact factor (IF) include three in Molecular Neurobiology (IF of 5.47), two in Human Genetics (IF of 4.63), four in PloS One (IF of 3.73) and now six in Pharmacogenomics (IF 3.86).

For more information, please contact:

Prof. Datin Dr. Zahurin Bt Mohamed
Department of Pharmacology,
Faculty of Medicine,
University of Malaya,
50603 Kuala Lumpur,
MALAYSIA
Tel : +603-7967 4702/4703
Fax : +603-7967 4791
Email: [email protected]

Published: 26 Mar 2014

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Centre for Research Services (PPP)

Office of the Deputy Vice-Chancellor (Research & Innovation) 8th Floor, Chancellery University of Malaya 50603 Kuala Lumpur MALAYSIA

+603-7967 3202
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http://medicine.um.edu.my/?modul=DEPARTMENTS&pilihan=Pharmacology&subpil... The University Malaya Pharmacogenomics Laboratory

Reference: 

Siti Norsyuhada Roffeei, Gavin P Reynolds, Nor Zuraida Zainal, Mas Ayu Said, Ahmad Hatim, Syarinaz Ahmad Aida, Zahurin Mohamed. Association of FTO, LEPR and MTHFR gene polymorphisms with metabolic syndrome in schizophrenia patients receiving antipsychotics. Pharmacogenomics, 2014. 15(4): p. 477-85. 2. Hidayati Mohd Sha'ari, Batoul Sadat Haerian, Larry Baum, Junji Saruwatari, Hui Jan Tan Mohd Hanip Rafia, Azman Ali Raymond, Patrick Kwan, Takateru Ishitsu, Kazuko Nakagawa, Kheng Seang Lim, Zahurin Mohamed. ABCC2 rs2273697 and rs3740066 polymorphisms and resistance to antiepileptic drugs in Asia Pacific epilepsy cohorts. Pharmacogenomics, 2014. 15(4): p. 459-66.

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