Physics Medical physics

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in ACS Applied Nano Materials a new method to precisely measure nuclear elasticity—the stiffness or softness of the cell nucleus—in living cells. By employing a technique called Nanoendoscopy-AFM (NE-AFM), which inserts a nanoneedle probe directly into cells, the team revealed how cancer cell nuclei stiffen or soften depending on chromatin structure and environmental conditions. The findings provide fundamental insights into how the physical properties of cancer cell nuclei change during disease progression, highlighting their potential as biomarkers for diagnosis and treatment evaluation.

We move our eyes several times per second. These fast eye movements, called saccades, create large image shifts on the retina - making our visual system work hard to maintain a stable perceptual world. Remapping the retinal image compensates for this; however, errors in actual eye movements cause image shifts, even with remapping.

A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has presented the notion of “DNA Phase Separation”, which suggests that the DNA within the nucleus may trigger phase separation, like oil in water.