The American Journal of Sports Medicine

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Regenerated meniscus stained with toluidine blue, using an Achilles tendon graft.
26 Aug 2022
The meniscus—a cartilage cushion in the knee—can be damaged by sports injuries or aging, but rarely heals on its own. A torn meniscus is often treated with resection, which is doomed to degeneration of the articular cartilage. For knees that have had the meniscus resected, meniscus reconstruction using autologous tendons has been performed in some countries, including Japan, but the results have not been consistent. A research group at the Department of Orthopedic Surgery, Graduate School of Medicine, Osaka Metropolitan University discovered an extra step that changes transplanted tendon tissue to make it similar to the original meniscus, providing better knee cartilage protection. They found that parathyroid hormone, a drug used to treat osteoporosis, acted on tendon-derived cells to promote chondrogenic differentiation, which recreated a meniscus-like tissue.
06 Aug 2022
Osaka Metropolitan University scientists revealed quadriceps tendon-patellar bone (QTB) grafts as a more suitable option than bone-patellar tendon-bone (BPTB) grafts for anterior cruciate ligament (ACL) reconstruction. Examinations in human cadavers and ACL reconstruction patients showed that the QTB graft is more similar to the ACL at the femoral insertion site than the BPTB graft. The difference between graft bending angle (GBA) and an angle corresponding to GBA showed that the QTB graft bends less than the BPTB graft, suggesting a lower risk of excessive stress on the insertion site and thereby a lower probability of ACL reconstruction failures. These findings contribute to potential improvement in ACL reconstruction for knee injury patients.

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