Journal of the American Society of Nephrology

Scientists from Duke-NUS Medical School have identified a gene that plays a crucial role in regulating energy supply to cells that drive kidney failure. This discovery concerning the gene, named WWP2, offers a new target for therapies aimed at mitigating kidney scarring and damage.

Tests using a mouse model of Alport syndrome suggests that turning off a cell signalling protein may significantly prolong life by preventing kidney scarring.

Studying Finnish genes leads to unique revelations about the development of a serious complication of diabetes, and informs an ongoing genomic study of a Singaporean cohort as part of Singapore’s Diabetes Study in Nephropathy and other Microvascular Complications (DYNAMO).