Journal of Materials Chemistry B

This is a novel study that attempted to construct a pH-sensitive delivery system into T cells and their subsets using carboxy-terminal Phe- and CHex-modified dendrimers with different structures, i.e. PAMAM-CHex-Phe and PAMAM-Phe-CHex. The findings contribute to the development of nanoplatforms for direct delivery to T cells to control the functions of T cells, which play key roles in cancer immunotherapy. This is the first report on direct delivery into T cells using pH-sensitive DDS.