Molecular Psychiatry

Researchers from Osaka University have found that, after chronic social isolation, one form of ketamine—(R)-ketamine—is effective for restoring neuronal activation in a brain region known as the anterior insular cortex. This restored activation leads to improvements in social impairments in a mouse model of depression. Together, these findings indicate that (R)-ketamine is a promising treatment for social symptoms of depression and may lead to better quality of life for millions of people worldwide.

- Discovery of potential treatment target networks for gene dysregulation uniquely found in patients with autism spectrum disorder - Published in ‘Molecular Psychiatry,’ an international journal of molecular psychiatry

A research team in South Korea has clarified the expression of antidepressant efficacy by modulating hippocampal mossy cells. It is expected to provide a basis to understand the mechanism of existing anti-depressants and contribute greatly to the development of next generation depression treatment.