Nature Cell Biology

A research team led by Tohoku University revealed the details of a calcium-driven mechanism that could provide insight into how to prevent Type 2 diabetes, Alzheimer's and amyotrophic lateral sclerosis (ALS).

We have succeeded in establishing a mouse model that develops gastric cancer closely resembling advanced human gastric cancer. Using this model, we have discovered gastric cancer stem cells, i.e. Lgr5+ gastric cancer cells, essential for the development, maintenance, and metastasis of cancer. Our study provides an experimental system that enables detailed analysis of highly malignant gastric cancer and is expected to lead to the development of a breakthrough treatment for advanced human gastric cancer.