Journal of Clinical Immunology

Researchers led by Osaka University identified plasma proteins associated with critical pathogenesis in COVID-19. Using a novel blood proteomics method, the researchers evaluated two discovery cohorts and one validation cohort of patients with COVID-19 and healthy volunteers. Cell adhesion proteins WFDC2, GDF15, CHI3L1, and KRT19 were shown to be associated with disease severity in patients with COVID-19, and may serve as potential targets for therapies to treat COVID-19 infection.

Researchers baffled by an infant’s rare encephalitis case unusual in children found unheard-of mutations and a new way to examine the “immunity gene.”