Clinical Gastroenterology and Hepatology

Hereditary colorectal cancer (CRC) accounts for 5-10% of all CRC cases, influencing familial risk and early onset. This study revealed the genetic landscape of CRC in Taiwan, identifying novel and population-specific variants that enhance hereditary risk assessment.

Researchers at Osaka Metropolitan University have developed an AI model for diagnosing esophageal achalasia using chest X-rays. The AI model demonstrated higher sensitivity and specificity than physicians in its diagnostic capability.

Functional cure, defined as durable hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA titers below the lower limit of detection (LLOD), is associated with better clinical outcomes of chronic HBV infection and regarded as the preferred treatment endpoint of novel therapeutic agents against HBV. Scientists from the College of Medicine of National Taiwan University and National Taiwan University Children’s Hospital identified that the Hepatitis B e antigen (HBeAg) seroconversion in childhood, high-genetic-barrier nucleos(t)ide analogue(s) therapy before HBeAg seroconversion, and the HBsAg titer < 1000 IU/mL after HBeAg seroconversion are predictors of functional cure. Findings demonstrated the merit of the follow-up and treatment of chronic HBV infection from childhood.

The rising trend of high-risk colorectal neoplasia rates in people under 50 in Taiwan is prompting a policy of early colorectal cancer screening.

First epidemiological study on incidence of EoE in Japan

An international research collaboration has discovered a potential new diagnostic marker for ulcerative colitis in a trans-ethnic analysis. The finding could lead to the development of a non-invasive, diagnostic blood test to both identify the disease and to determine progression in patients, according to the researchers.