Critical Care

Researchers from Osaka University used machine learning to identify subgroups of trauma patients who are more likely to survive their injuries if treated with tranexamic acid. This treatment controls bleeding and thereby prevents death from hemorrhage. The team also identified subgroups of trauma patients who do not benefit from tranexamic acid. These findings should help guide treatment decisions after traumatic injury and provide trauma patients with more personalized care.

Researchers from Osaka University have found that repeated high-dose treatment, known as pulse therapy, with the steroid methylprednisolone reduces in-hospital deaths in COVID-19 patients who receive invasive mechanical ventilation, but not in patients who don’t receive invasive mechanical ventilation. These findings were only possible using appropriate statistical methods to remove bias from the data, which originally seemed to show that the opposite was true. These results can improve patient treatment and reduce COVID-19-related deaths worldwide.

Osaka University researchers used a large dataset of trauma patients in Japan to determine the characteristics and biomarkers most strongly associated with mortality risk by employing machine learning methods. This work may help improve the practice of emergency medicine.