Diabetes Care

A large cohort study conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine), in collaboration with investigators from the University of Sydney, Australia, has discovered that shortened DNA telomere length is a useful biomarker linked to a higher risk of developing cardiovascular disease in patients with type 2 diabetes. The Endocrinology and Diabetes team of CU Medicine evaluated this biomarker in over 5,300 type 2 diabetes patients during a 13-year follow-up period. Patients with cardiovascular disease at baseline or during follow-up had shorter tail-ends of DNA strands, expressed as relative Leukocyte Telomere Length (rLTL), than those who never had cardiovascular disease. For each unit relative decrease in rLTL, the risk of cardiovascular disease increased by 25%. These results have been published in the leading diabetes journal, Diabetes Care.

Researchers from the School of Biomedical Sciences of the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) have recently applied an advanced statistical approach to analyse risk factors that may be causally related to COVID-19 infection. Results suggested that diabetes may be a risk factor leading to increased susceptibility to or severity of COVID-19 infection through changes in ACE2 expression, which is a key receptor for the virus. A substantial proportion of COVID-19 death cases in Hong Kong suffered from diabetes. There is an urgent need to confirm risk factors and the mechanisms in order to protect the susceptible groups and identify effective treatments. The current study results were recently published in the international scientific journal Diabetes Care.