Immunity
News
30 May 2024
Research collaboration between Osaka University and Otsuka Pharmaceutical Co., Ltd. revealed that deletion of mRNA endonuclease Regnase-1 promoted NK cell anti-tumor activity via OCT2-dependent transcriptional up-regulation of Ifng mRNA. Associated with the deletion of Regnase-1 in NK cells, NK cells showed a high expression of OCT2 and CXCR6 in those that escaped from mRNA decay from Regnase-1, and they contributed to the transcriptional regulation of Ifng and NK cell persistence inside the tumor microenvironment, respectively. The loss-of-function strategy targeting Regnase-1 potentially enhances the production of cytotoxic proteins such as IFN-γ, granzymes, and perforin. This approach also promotes NK cell infiltration and persistence within the tumor, thereby facilitating the development of effective anti-tumor immunotherapy against solid tumors.
24 Nov 2022
Understanding how bats tolerate viral infections without developing symptoms may lead to better ways of combatting human disease.
20 May 2020
Research into how the SARS-CoV-2 virus induces death is suggesting potential treatments for its most destructive complications.