Journal of Clinical Investigation

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UHRF1 controls DNA methylation of synovial fibroblasts in RA patients.
07 Jun 2022
Potential of a novel therapeutic strategy for rheumatoid arthritis by UHRF1 stabilization We identified an epigenetic regulator UHRF1 that suppresses various pathogeneses in rheumatoid arthritis. The UHRF1 expression level in synovium showed a negative correlation with the severity of pathogenesis in patients with rheumatoid arthritis and mouse arthritis models. In addition, stabilization of the UHRF1 expression achieved improvement of the arthritis pathology. Our results indicate that the stabilization of the UHRF1 protein is a potential therapeutic strategy for rheumatoid arthritis patients.
02 Sep 2021
A rapid way to track an elusive part of the immune system will bring better vaccine strategies
27 Aug 2019
New study reveals enzyme plays key role in potentially fatal dengue haemorrhagic fever and shock; suggests clinically approved tryptase inhibitor could be key in future targeted treatment.
The cultured cells lacking gcn5l1(right) formed thicker muscle fibers comparing to normal cells (left).
14 Jun 2018
A metabolic process that provides heart muscle with energy fails to mature in newborns with thickened heart walls, according to a Japan­–Canada research team.
23 Apr 2010
Therapeutic strategies that block inflammatory response to islet cell transplantation may accelerate treatment of diabetic patients

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