Journal of Clinical Investigation

Research led by National Yang Ming Chiao Tung University and National Taiwan University uncovers a successful postnatal gene therapy strategy that restores hearing and preserves inner ear structures in a hereditary deafness model. This breakthrough identifies vital therapeutic windows after birth, paving a clear path toward clinical translation for genetic hearing loss.

We identified Mrep macrophages that repair muscle but trigger heterotopic ossification in FOP, advancing muscle and FOP therapy development.

Discovery reveals how drug-resistant tumours can shift into a state that responds better to chemotherapy.

• International researchers led by Duke-NUS identify rare mutations in the SPNS1 gene as the cause of a previously undiagnosed multi-organ disorder • Faulty fat recycling in cells triggers damaging build-up in muscles and liver • Findings lay the groundwork for new therapies for affected families

Researchers from The University of Osaka found that PM2.5 air pollutants negatively affect mucociliary clearance, a protective mechanism of the respiratory tract. Air pollution led to the formation of lipid peroxide-derived aldehydes, known to damage protective cells in the airway and increase the risk of infections. ALDH1A1 was found to play an important role in protection against aldehydes, making it a potential therapeutic target to diminish the negative effects of air pollution.

A Duke-NUS Medical School-led study highlights the role of natural killer T cells in influencing the immune response to dengue virus, potentially reducing the severity of subsequent infections.

A study led by Duke-NUS Medical School has found an important connection between cancer, stem cells and the building blocks of cholesterol. Specifically, the research reveals how the enzyme FAXDC2 influences cancer cell growth and differentiation through its role in cholesterol synthesis, suggesting possible new approaches to cancer treatment.

Omega-3 lysolipids are important for protecting the liver from dietary fat, according to Duke-NUS researchers and collaborators from SGH.

Scientists have found a lipid transporter crucial to regulating the cells that make myelin, the nerve-protecting sheath.

Potential of a novel therapeutic strategy for rheumatoid arthritis by UHRF1 stabilization We identified an epigenetic regulator UHRF1 that suppresses various pathogeneses in rheumatoid arthritis. The UHRF1 expression level in synovium showed a negative correlation with the severity of pathogenesis in patients with rheumatoid arthritis and mouse arthritis models. In addition, stabilization of the UHRF1 expression achieved improvement of the arthritis pathology. Our results indicate that the stabilization of the UHRF1 protein is a potential therapeutic strategy for rheumatoid arthritis patients.

A rapid way to track an elusive part of the immune system will bring better vaccine strategies

New study reveals enzyme plays key role in potentially fatal dengue haemorrhagic fever and shock; suggests clinically approved tryptase inhibitor could be key in future targeted treatment.

A metabolic process that provides heart muscle with energy fails to mature in newborns with thickened heart walls, according to a Japan­–Canada research team.

Therapeutic strategies that block inflammatory response to islet cell transplantation may accelerate treatment of diabetic patients