Molecular Cell

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4.5SH RNA (green) is located in the nuclear speckles (Srsf1, magenta)—structures in the cell nucleus associated with gene expression—in embryonic stem cells, where it plays an essential role in RNA processing. (Rei Yoshimoto, et al. Molecular Cell. December 13, 2023)
13 Dec 2023
A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.
08 Jun 2023
A team led by researchers from Osaka University elucidated a molecular mechanism that is crucial for separating genetic material into daughter cells during cell division. A protein called CENP-C is part of a complex called the kinetochore, which supports the movement of chromosomes. Two portions of CENP-C, the CCAN-binding domain and Cupin domain, are needed for CENP-C to function. The Cupin domain repeats itself through oligomerization, which is essential for proper CENP-C function.
25 Aug 2022
Thousands of short RNA sequences that code for microproteins and peptides have been identified, opening new avenues for disease research and drug development.
01 Oct 2021
Tohoku University researchers, collaborating with colleagues from the Indian Institute of Technology Kanpur, have discovered the working mechanism of an important class of drug target receptor proteins.
26 Mar 2021
An ‘eat-me’ signal displayed on cell surfaces requires activation of a lipid-scrambling protein by a nuclear protein fragment.
12 May 2020
In a recent study published in Molecular Cell, researchers at Kanazawa University report the role of cellular structures called PML bodies in regulating gene function
28 Nov 2019
New molecules that tag cellular components for removal could lead to drugs for a wide range of diseases.

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