Signal Transduction and Targeted Therapy

Burkitt's lymphoma is a highly aggressive blood cancer that primarily affects children and young adults. It is driven by a genetic alteration involving the MYC gene. Researchers have now developed a novel treatment approach in mice that combines CAR-T cell therapy with limited doses of a SUMOylation inhibitor, which can target MYC. This combination dramatically improved cure rates, paving the way for a potential new treatment strategy for this aggressive cancer.

A research team led by Hong Kong Baptist University (HKBU) has developed a novel drug delivery system for Alzheimer’s disease (AD). The researchers have engineered exosomes, extracellular vesicles released by cells, to effectively carry the bioactive compound Corynoxine-B extracted from the Chinese herbal medicine Gouteng to the brain of mice with AD. As Corynoxine-B can induce autophagy, a process that maintains the health of cells, this new drug delivery system using exosomes can improve cognitive function and movement while reducing the symptoms of AD.