Gut Microbes

Host genetics-driven expansion of invasive Escherichia coli in the gut microbiome exacerbated tumorigenesis by targeting Hippo pathways to induce cancer stemness via CD44 upregulation. Mouse models of Apc gene mutation and bacteria-epithelial cell cocultures provided proof of concept that invasive bacteria derived from commensal microbes enhanced epithelial clonogenicity. Our data support the use of bacterial precision medicine as an alternative strategy for managing colorectal cancers, even in the hereditary subset.

A new study suggests that the gut may play a surprising role in childhood migraine. Researchers found that improving gut health could help reduce headache pain and frequency in some children.

The study identifies gut microbes and genes that regulate TMAO production from L-carnitine, offering potential for personalized nutrition strategies.

Gut microbe isolated from infertile women disrupts progesterone metabolism, lowering progesterone levels and impairing ovarian follicular development.