Dr. Sonia Chotani

Dr. Sonia Chotani is a computational biologist working in the area of small open reading frames and RNA translation in human diseases.


PhD. Computational Biology. Duke-NUS Medical School (2020)
M.Sc. Computational Biology. Carnegie Mellon University (2014)
Bachelor of Technology. Biotechnology. Indian Institute of Technology, Madras (2012)

She has developed approaches to identify novel targets in human disease by integrating several different next-generation sequencing technologies (Ribo-seq, RNA-seq, CLIP-seq, single-cell RNA-seq). She has applied these approaches to changes in human cardiac fibrosis and identified the RNA-binding protein network in cardiac scarring which was further shown to be active in patients with cardiac fibrosis.

She is currently working on developing an atlas of human micropeptides across various human cell-types and tissues. This work involves integrating large amounts of data, applying multiple algorithms and developing an easily available resource for researchers.

Selected publications

Chothani S,*, Schafer S*, Adami E*, Viswanathan S, Widjaja AA, Langley SR, Tan J, Wang M, Quaife NM, Pua CJ, D'Agostino G, Shekeran SG, George BL, Lim S, Cao EY, van Heesch S, Witte F, Felkin LE, Christodoulou EG, Dong J, Blachut S, Patone G, Barton PJR, Hubner N, Cook SA+, Rackham OJL+. Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins. Circulation. 2019 Sep 10; 140(11):937-951; Publication highlighted in Nature Reviews Cardiology, "Cardiac  brosis research: Two steps forward".

Chothani S, Adami, E., Ouyang, J.F., Viswanathan, S., Hubner, N., Cook, S.A., Schafer, S., and Rackham, O.J.L. deltaTE: Detection of Translationally Regulated Genes by Integrative Analysis of Ribo-seq and RNA-seq Data. Current Protocols in Molecular Biology. 2019. V129.

Ng B, Dong J, Viswanathan S, DAgostino G, Widjaja A, Lim W, Ko N, Tan J, Chothani S, Huang B, Xie C, Chacko AM, Guimaraes-Camboa N, Evans S, Byrne A, Maher T, Liang J, Noble P, Schafer S, Cook S. IL-11 is a therapeutic target in idiopathic pulmonary  brosis. Sci Transl Med. 2019 Sep 25;11(511)

WidjajaA, SinghB, AdamiE, ViswanathanS, DongJ, D'AgostinoGA, NgB, LimWW, TanJ, PalejaBS, TripathiM, LimSY, ShekeranSG, Chothani S, RabesA, SombetzkiM, BruinstroopE, MinLP, SinhaRA, AlbaniS, YenPM, SchaferS, CookSA. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis. Gastroenterology. 2019 Sep;157(3):777-792.e14

Zhou, J., Ng, B., Ko, N.S.J., Fiedler, L.R., Khin, E., Lim, A., Sahib, N.E., Wu, Y., Chothani, S.P., Schafer, S., et al.. Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. Hum. Mol. Genet. 2019 Jun 15;28(12):1971-1981

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Dr. Sonia Chotani
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