Professor Yuichi Taniguchi

Biological functions such as cellular differentiation are often regulated by vast numbers of molecules. Elucidating the general principles behind the organization of these complex molecular environments is a critical challenge.

Our laboratory addresses this challenge by developing new technologies for the large-scale characterization and manipulation of intracellular molecular activities. By integrating knowledge from multiple academic fields, including biology, chemistry, physics, medicine, and informatics, we aim to understand, predict, and control intracellular molecular interactions.

Fields of expertise

Biophysics and Systems Biology

Research History

2020-present Adjunct Professor in Graduate School of Frontier Biosciences, Osaka University
2020-present Professor in Graduate School of Biostudies, Kyoto University
2020-present Professor in Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University (PI)
2020-present Team Leader in RIKEN Center for Biosystems Dynamics Research (PI)
2011-2020 Adjunct Associate Professor in Graduate School of Frontier Biosciences, Osaka University 
2011-2020 Unit Leader in Quantitative Biology Center, RIKEN (PI)
2006-2011 Postdoctoral fellow in Department of Chemistry and Chemical Biology, Harvard University (supervisor: Prof. Xiaoliang Sunney Xie)
2006 Ph.D. in Graduate School of Engineering Science, Osaka University (supervisor: Prof. Toshio Yanagida)
2003 M.S. in Graduate School of Engineering Science, Osaka University (supervisor: Prof. Toshio Yanagida)
2001 B.S. in School of Engineering Science, Osaka University

Selected publications

1. Kumar, V., Leclerc, S., Taniguchi, Y. “BHi-Cect: A top-down algorithm for identifying the multi-scale hierarchical structure of chromosomes”, Nucleic Acids Research, 48, e26 (2020)
2. Ohno, M., Ando, T., Priest, D. G., Kumar, V., Yoshida, Y., Taniguchi, Y. “Sub-nucleosomal genome structure reveals distinct nucleosome folding motifs”, Cell 176, 520-534 (2019)
3. Leclerc, S., Arntz, Y., Taniguchi, Y. “Extending single molecule imaging to proteome analysis by quantitation of fluorescent labeling homogeneity in complex protein samples”, Bioconjugate Chemistry 29, 2541-2549 (2018)
4. Priest, D.G., Tanaka, N., Tanaka, Y., Taniguchi, Y. “Micro-patterned agarose gel devices for single-cell high-throughput microscopy of E. coli cells”, Scientific Reports 7 17750 (2017)
5. Taniguchi, Y., Choi, P. J., Li, G., Chen, H., Hearn, J., Babu, M., Emili, A. & Xie, X. S. “Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells”, Science 329, 533-538 (2010)
6. Taniguchi, Y., Nishiyama, M., Ishii, Y. & Yanagida, T. “Entropy rectifies the Brownian steps of kinesin”, Nature Chemical Biology 1, 342-347 (2005)