Biology Histology

Using a new fluorescent mouse model with advanced imaging techniques, researchers have successfully visualized how musculoskeletal components are integrated into the functional locomotor system during embryonic development.

Researchers from Osaka University have shown that a system known as the GET pathway is essential for efficient mitophagy, the process by which mitochondria are removed from cells. The GET pathway targets a protein assembly called the Ppg1–Far complex, which inhibits mitophagy, to the membrane of a part of the cell called the endoplasmic reticulum. When the GET pathway is defective, this complex instead becomes targeted to mitochondria, where it acts to suppress mitophagy.