Medicine & Healthcare Medical toxicology

Medication-related osteonecrosis of the jaw (MRONJ) can be difficult to treat once it develops, making prevention especially important. In a retrospective study, a Hiroshima University researcher found that quantitative measurements extracted from CT images taken before treatment, when analyzed with machine learning, could distinguish patients who later developed the condition from those who did not—an early step toward predicting MRONJ risk before bone resorption inhibitor therapy begins.

Researchers found that FK 23, a lactic acid bacterium-derived material, improved the sperm dysfunction induced by bisphenol A (BPA)—a chemical commonly used in plastic production including food containers—using a rat model.

Abnormally high levels of DNA methylation have been identified in dogs exposed to high levels of lead near a mining area in Kabwe, Zambia, by a team of scientists from Japan and Zambia.

Scientists have unveiled a correlation between high blood lead levels in children and methylation of genes involved in haem synthesis and carcinogenesis, indicating a previously unknown mechanism for lead poisoning.

A study conducted over the past 18 years has found differences between lead exposure effects in young Japanese boys versus girls.