MedChem India

Topics developed in the agenda:

Target Identification
Lead Optimisation
Natural Product Synthesis
SAR and Molecular Modelling
Partnering
Microwave-Assisted Organic Synthesis
Case Studies

Conference Chairman

Kumar Gadamasetti
President & CEO
Delphian Pharmaceuticals

Take the rare opportunity to attend the pre-conference training course on Microwave-Assisted Organic Synthesis given by the renowned pioneer Prof. C. Oliver Kappe.

Call for Posters
You can also present your research on a poster while attending the meeting. Submit an abstract for consideration now!

Sponsorship and Exhibition Opportunities
[email protected]
+44 (0) 1787 315117

Agenda
(additional talks and exact timing will be confirmed shortly)

18 March 2008

8:00
Registration

9:00
Conference Chair Welcome Address
Kumar Gadamasetti, President & CEO, Delphian Pharmaceuticals

9:10
Pharma Development and Case Studies

9:15
Drug Discovery: Key Learning From Recent Success Stories - A Medicinal Chemistry Perspective
Bharat K.Trivedi , CSO, Medicinal Chemistry, Drug Discovery Research, Wockhardt
SAR and pre-clinical strategies that led to the discovery and development of a successful therapeutic agent in a given therapeutic area will be presented along with a perspective on what is essential for Indian pharma to be globally competitive.

9:55
Drug Discovery Alliance Between Ranbaxy and GlaxoSmithKline, a Case History
Pradip Bhatnagar, Sr.VP, New Drug Discovery Research, Ranbaxy Pharmaceuticals

10:35
Coffee break and networking in exhibition hall

11:20
Interaction of Commercial, Discovery and Development: Medicinal Products of Differentiated Value
Kumar Rajinder, President of Research, Development and Commercialization, Dr. Reddy’s Laboratories Ltd

12:00
Green Chemistry Influence in Medicinal Chemistry
Asit K. Chakraborti, Professor and Head of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER)
Scope of green chemistry in drug design will be discussed with reference to develop novel concepts (e.g., demand-based thiolate anion generation, atom-economy in alkylation, water catalysis by electrophile-nucleophile dual activation through cooperative hydrogen bond formation), solvent-free reactions and microwave-assisted synthesis.

12:30
Lunch & networking in exhibition hall followed by poster viewing

14:00
Modelling, SAR and Synthesis

14:10
Relating Molecular Structure to Biological Activity
Robert A. Volkmann, Senior Research Fellow, Pfizer Global R&D
A strategy for capturing “system-wide” drug-effect information of medicines will be described. The potential application of this method in drug discovery will be illustrated.

14:50
Discovery of Novel Anti-Infectives Through SAR Studies
Uma Ramamchandran, Vice President - Medicinal Chemistry , Orchid Research Laboratories
Orchid Research Laboratories' effort to expand the spectrum of antibacterial activity of the oxazolidinones to include gram-negative organisms has led to the discovery of the novel oxazolidinone scaffold, which has superior in vitro activity, excellent PK profile and comparable in vivo efficacy to Linezolid.

15:20
ADME Prediction in Drug Design
Ismael Zamora, Associate Professor, Lead Molecular Design, Pompeu Fabra University
Several methods to predict drug absorption (passive and active), CYP mediated metabolism and CYP inhibition and applications of the results to synthesize of new chemical structure will be presented.

15:50
Coffee break and networking in exhibition hall

16:30
Increasing the Throughput in Microwave Synthesis - Going Parallel
C. Oliver Kappe, Professor of Organic Chemistry, University of Graz
Microwave chemistry can be carried out very efficiently in a parallel format using dedicated rotors or microtiter plate systems. Several hundred reactions can be performed in a single microwave experiment using multimode microwave devices.

17:00
Homogeneous and Heterogeneous Palladium-Mediated Cross-Coupling Reactions Using Controlled Single- and Multi-Mode Microwave Heating
Uwe Schön, Principal Scientist Medicinal Chemistry, Solvay Pharmaceuticals
Different boronic acids and homogeneous and heterogeneous palladium sources under microwave irradiating conditions using single-mode and multi-mode microwave equipment will be compared. Examples of running medicinal chemistry programs will be presented.

17:30
Drinks reception (Sponsorship available, please contact [email protected] for further details)

19 March 2008

9:30
Target Identification

9:35
Ultra High Throughput Monoclonal Antibody Production
Michael Spiegel, Deputy Director, Monash University
The use of custom-made, high-affinity monoclonal antibodies has proven crucial in medicinal chemistry. High-throughput production using patented screening technology and state-of-the-art robotics systems will be discussed.

10:05

A Novel Approach for Identifying Phamacophore Moiety Within Large Biologically Active Natural Products
Hakim Djaballah, Director, HTS Core Facility, Memorial Sloan Kettering Cancer Centre
A novel strategy for identifying critical pharmacophore within active natural products can be employed towards other biologically active natural products to make them more synthetically accessible as potential therapies.

10:35
Coffee break and networking in exhibition hall

11:00
Chiral Conformations and Host Immune Clearance Patterns
Marcella Mascarenhas, Research Scientist-Biologist, Independant Collaborative Research

11:30
BioMEMS Based Target Detection of Heat Shock Protein 90 Interactions
Muthukumaran Packirisamy, Associate Professor and Research Chair, Concordia University
The target identification of Heat Shock Protein 90 (HSP90) interactions through bio-mechanical interactions using a highly sensitive BioMEMS technique that has high specificity and high throughput will be presented.

12:00
Lunch & networking in exhibition hall followed by poster viewing

13:30
Lead Optimisation & Business Partnering

13:05

Drug Discovery Studies to Treat Tuberculosis
Bala Ganesh Tanjore, Head of Research, VP-Discovery, AstraZeneca-India

14:05

Eradication of M.TB Infection in Two Months with LL-3858 (Sudoterb): A Preclinical Study
Sudershan Arora, President R&D, Lupin Pharmaceuticals
Research suggests that LL4858 is a novel combination consisting of a novel antimycobacterial compound (LL3858) that is safe, non-toxic and provides effective cure against tuberculosis in two months in our preclinical studies.

14:35

Coffee Break and Poster Award Ceremony

15:00
Discovery of IsentressTM, First in Class HIV Integrase Inhibitor for the Treatment of HIV Infection
Vincenzo Summa, Director, Merck-MRL ROME
HIV remains a serious health problem despite the progress obtained with HAART. IsentressTM is the first HIV Integrase inhibitor approved for the treatment of HIV-1 infection, with a completely novel mechanism. Details on its discovery will be presented.

15:30
String of Pearls: Orchestrating the Best Outcomes from Multiple Partners in Medicinal Chemistry Program
Swami Subramaniam, Head, India Operations and Director, Business Development, Rheosciences A/S

16:00
Discovery of Novel 4-Aminoquinazolines and C-2, C-8 and N-9 Trisubstituted Purines as Potent Aurora-A Kinase Inhibitors
Parthasarathi Das, Research Investigator, Dr. Reddys Laboratories
The validation of Aurora kinases as a drug target has spawned a flurry of activity over the last few years, directed towards the discovery of novel Aurora kinase inhibitors with potential for anticancer drug therapy.

16:30
Conference Chair Closing Remarks
Kumar Gadamasetti, President & CEO, Delphian Pharmaceuticals

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Pre-conference course
Microwave-Assisted Organic Synthesis

This course will be held between 8am and 4pm on 17 March 2008. The course tutor is Dr. C. Oliver Kappe.

Who should attend?

Chemists from industry, academia or government who are involved in basic research in biotechnology, pharmaceutical, agrochemical, or related synthetic topics. These could include medicinal, organic, and high-throughput chemists in addition to scientists involved in process research. A basic knowledge of chemistry is required. The course is designed to make participants familiar with this emerging field, and improve the synthetic productivity of any practicing B.S., M.S., and Ph.D. chemist. This course will be valuable to both industrial and academic researchers currently involved with, or intending to become active in the area of microwave synthesis.

What will I gain by attending?

Obtain a state of the art introduction and training in this dynamic field
Understand the theory and concepts behind microwave synthesis
Become familiar with all major types of commercially available microwave reactors from different vendors
Learn to apply microwave chemistry to your synthetic chemistry problems
Hear about a diverse set of chemistries and applications during the course
Find out about future trends in microwave chemistry in particular in process and scale-up
Discover where to look for more advanced information, using the extensive references provided

With time allowed for open questions and discussion, this one day course will enable the audience to get to grips with most of the issues involved in microwave synthesis. All participants will receive a comprehensive set of notes in CD-ROM format consisting of the material presented in the morning and afternoon sessions in addition a 2002-2007 literature survey with close to ca 700 references on controlled microwave synthesis.

http://www.selectbiosciences.com/conferences/MCI2008/index.aspx