Cancer Research

Researchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß pathway. The findings may lead to a new approach for colorectal cancer therapy.

Researchers from Osaka University have revealed the mechanism by which increased signaling through a pathway associated with a molecule called Wnt leads to the development of liver cancer. They identified a gene called GREB1 as a target of Wnt specifically in liver cancer. This gene alters the function of a protein called HNF4α, leading to the development of cancer. They also showed that treatment of mice with antisense oligonucleotides against GREB1 had significant anti-cancer effects.

Osaka University researchers identified a novel mechanism by which expression of the tumor suppressor p53 paradoxically promotes liver cancer development in patients with chronic liver disease. By generating a mouse model with constant p53 expression in its liver cells, the team observed increased numbers of hepatic progenitor cells (HPCs) and liver cancer incidence. These HPCs could induce cancer when injected into certain mice. This did not occur with p53 deleted, demonstrating its critical significance.

Cancer is a disease driven by mutations that alter the way biochemical signals control cell growth, division and migration. Scientists at Duke-NUS Medical School found out that, like Goldilocks, cancer is very picky about getting rapid growth just right.

Testing for mutations in RNF43, a protein that affects key cancer cell-growth pathway Wnt, gives clinicians actionable insights to tailor treatments better.

Scientists at Hokkaido University and collaborators have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance, resulting in poor prognosis of cancer patients.

A multidisciplinary team of researchers at Japan's Tohoku University has found that a gene regulator, called BACH1, facilitates the spread of pancreatic cancer to other parts of the body. The scientists, who published their findings in the journal Cancer Research, say drugs that control BACH1 could improve disease prognosis.

World Cancer Research Fund (WCRF) is now accepting grant applications for research on the links between diet, nutrition (including body composition), physical activity and cancer, as part of its Regular Grant Programme 2019/2020 cycle.

Send your research news on a world tour in the 2020 Asia Research News magazine. Submissions due by July 15. The submission form is at the bottom of this article.

Research shows that up to 50 percent of cancer cases and deaths are preventable. Cancer prevention is the most cost-effective and sustainable long-term strategy for the control of cancer.

Loss of a protein called TRIM29 promotes cancer cell invasion in a common type of skin cancer, suggesting a novel diagnostic marker and a possible therapeutic target.

South Korea's Ulsan National Institute of Science and Technology (UNIST) has been selected for the 2018 Basic Research Projects in Science and Engineering.

Converging the latest cancer discoveries around the world, FCS 2018 promises ground-breaking and innovative insights into cancer research. Join us and learn from the foremost cancer experts as they share their newest findings.

World Cancer Research Fund International (WCRF International) is now accepting grant applications for research on the links between diet, nutrition (including body composition), physical activity and cancer prevention and survival as part of their Regular Grant Programme 2018/2019 cycle.

New study revises biologists’ understanding of how limbs and lungs develop in humans.

WCRF International is now accepting grant applications for research on the links between diet, nutrition (including body composition) and physical activity and cancer. Applicants can be based in any country outside the Americas.

November 6-8, 2017 - Matrix Auditorium, Biopolis, Singapore

A joint symposium on "Coping with Incurable Disease" was held at Pusan National University Yangsan Hospital (PNUYH) in Pusan, South Korea, to accelerate the development of new drugs to treat incurable diseases.

National platform for research imaging to study the impact of new therapies in key disease areas relevant to Singapore and the region.

World Cancer Research Fund International Regular Grant Programme 2015/2016 cycle is now open for applications. The grant programme accepts applications on the effects of diet, nutrition (including body composition) and physical activity on cancer. More information from www.wcrf.org/apply. Deadline for applications is 9 October 2015.

Researchers in Singapore have developed an ultrasensitive method to detect micro-RNAs: tiny molecules that can indicate the presence of tumours. They are applying the technology toward a non-invasive screening test for gastric cancer.

World Cancer Research Fund International is accepting research grant applications on the links between diet, nutrition, body composition, physical activity and cancer. Please pass this information on to colleagues who might be interested in applying. Deadline for submission is 10 October 2014. Visit www.wcrf.org/apply for more information.

Genetic variants associated with haematological cancers, which affect the blood, bone marrow, and lymph nodes, are reported in two independent studies this week in Nature Genetics.

Dr Vincent Keng Wee-keong of HKPolyU and international colleagues have developed a sophisticated model for studying "Malignant Peripheral Nerve Sheath Tumors" (MPNSTs), paving the way for further discovery of new genes and genetic pathways that may provide new therapeutic targets for related cancer treatment.

Genome sequencing of a global collection of Shigella sonnei or baciliary dysentery, in developing countries is reported in a study published in Nature Genetics. Their study provides insights into the course of recent shigellosis epidemics. S. sonnei are human-adapted E. coli responsible for approximately 150 million cases of dysentery each year.

The genome sequence of the tomato, a major crop plant and a model system for fruit development, is published in this week’s Nature. Analysis of the sequence provides insights into the evolution of genes that control fruit characteristics, such as colour and fleshiness.

The latest from Nature and Nature Research Journals Sunday 29 April

Latest news from Nature 29 March 2012

A young scientist from PolyU's Food Safety and Technology Research Centre has successfully prepared highly stable selenium nanoparticles by using the polysaccharide-protein complex extracted from the African Tiger Milk mushroom.

Latest news from Nature 5 January 2012