Health

Zinc is essential for our health. Our bodies must constantly regulate its zinc levels, otherwise fatal diseases such as cancers, growth failures, ad immunodeficiency can occur. Now, a research group has unearthed how zinc transporter complexes regulate zinc ion concentrations in different areas of the Golgi apparatus.

A research team, led by researchers from Osaka University, performed genetic screening of fission yeast lacking DNA repair gene Rad51 to identify genes that play a role in gross chromosomal rearrangement (GCR), a type of mutation that occurs at the centromere. Cells lacking Srr1 or Skb1 exhibited reduced GCR, indicating that these genes are important to the occurrence of GCR. These findings advance our understanding of the mechanisms underlying centromeric GCR.

Eating fermented foods might be the secret to a healthy and long-lived society

Truck drivers unintentionally taking ‘microsleeps’ of a few seconds can cause terrible traffic accidents, but efforts and technologies aiming to prevent the problem have focused mainly on monitoring driver eye activity while missing a host of other key indicators of the problem.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a surprising antidote candidate for one of the deadliest mushrooms, why a certain species of spider walks like an ant, and the oldest primate embryos grown outside of the womb.

It’s not unusual for many of us to reach for a cup of coffee or cup of tea whilst focusing our attention on a screen. Scientists have long pondered whether our hand movements influence our spotlight attention. And now a group of researchers from Tohoku University have discovered that our spotlight attention and the attention paid to our moving hands operates via independent mechanisms.

Specially coated surfaces help scientists investigate what happens when cell clusters are turned upside down.

A protein that helps bats survive viral diseases might offer lessons for developing new anti-inflammatory treatments.

DGIST and New Life Group launched a research project on "Functional beauty and health products using the latest nanotechnology."

A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.

Osaka Metropolitan University scientists investigated the prevalence of antimicrobial resistant bacteria in 678 bacterial isolates from 428 companion dogs and 74 companion cats at the Veterinary Medical Center, Osaka Metropolitan University. Two E. coli strains have both a mobile colistin-resistant mcr gene and a third-generation cephalosporin-resistant blaCTX gene. One of these strains, which is found in a dog, was resistant to both colistin and third-generation cephalosporins.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a natural glue to hold stem cells in place, how cancer manipulates our immune cells, and the answer to Everest’s spooky nighttime noises.

Scientists have found a lipid transporter crucial to regulating the cells that make myelin, the nerve-protecting sheath.

HKBU joint research suggests that urine cytomegalovirus test facilitates early prediction of AIDS end-organ diseases

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a flu that could potentially jump from dogs to humans, a surgically-implanted chip that can help with serious addiction cravings, and a powerful jet emitted from a supermassive black hole.

Polycyclic aromatic hydrocarbons, in particular, lower the prognosis of ischemic strokes by causing inflammation in the brain.

Singapore scientists find use of healthcare resources, absenteeism and reduced productivity due to mental health issues place a significant burden on Singapore’s economy.

A research group at the Osaka Metropolitan University analyzed the relationship between diet, muscle mass, and liver fibrosis progression in 136 patients with nonalcoholic fatty liver disease attending the Osaka Metropolitan University Hospital. The research group found that the group with the highest Japanese diet score had less advanced liver fibrosis, and that the intake of soy products, seafood, and seaweed was important.

The Nobel prize winning physicist Niels Bohr once said, “An expert is a (person) that has made all the mistakes that can be made in a narrow field.” This idea that to master a skill we must learn from our mistakes and avoid making them in future has long been recognized; however, the brain mechanisms and pathways that control this ability have been poorly understood. We revealed a specific brain pathway that allows us to identify and learn from our mistakes to guide better decision-making in future. Our work is an important step towards understanding how the brain controls our daily choices and behavior. The identification of these cells as ‘mistake signalers’ may also help to guide new treatments for mental health conditions associated with impaired decision-making ability.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are bioprinting organs and tissues, settling a debate on a monster, and shedding light on dark matter.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are a foldable buggy that can be used on the moon, synthetic nano-nets to help combat antibiotic resistance, and how that new car smell may not be a good thing.

Doctors at King Chulalongkorn Memorial Hospital have developed lightweight and easy-to-use Parkinson's gloves that can automatically reduce tremors, allowing patients to enjoy social life and reducing side effects from medication and risk from brain surgery.

The COVID-19 pandemic has made us more aware of the aerosols that hang around in the air and spread certain infectious diseases. Common dental procedures can be potentially hazardous in this regard. Therefore, it is crucial for researchers to be able to measure how aerosols spread so they can reduce them. A recent study harnessed a high-sensitivity camera and a high intensity LED light source, along with a mannequin and dental air turbine, to measure the spread of aerosols and the effectiveness of various means to reduce them.

Asia Research News monitors the latest research news in Asia. Some highlights that caught our attention this week are snakes that do gymnastics to get out of danger, 3 species of ancient spiders discovered in China, and how monkeys can fall for magic tricks.

Ferroptosis is a recently discovered type of cell death associated with certain neurodegenerative, cardiovascular and kidney diseases. Whilst scientists have understood that accumulated iron and degenerated lipids trigger ferroptosis, the actual mechanisms at play have remained a mystery. A team of researchers from Tohoku University has identified where in the cells these accumulations take place, and what gets targeted as ferroptosis occurs.

Researchers from Osaka Metropolitan University Graduate School of Medicine conducted an interoperative comparison of lateral disc meniscus injuries of young patients (aged 15 or less), that were treated with plastic sutures or subtotal resection, to see if there was a difference in postoperative cartilage degeneration. The research group observed that sub-total meniscectomies were more likely to show cartilage degeneration, being worst in lateral disc meniscus injuries. In addition, they found that even with higher levels of meniscus damage, preserving the meniscus with sutures was more effective in protecting the cartilage in young patients.

· Duke-NUS sleep scientists’ analyses show associations between early classes, less sleep, poor attendance and reduced grade point average. · Studies in secondary and junior college students have shown that later start times can have positive impacts on grades.

Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. It has also been reported that vesicles called exosomes produced by these CAFs play an important role in cancer progression. An Osaka Metropolitan University research group investigated the effect of CAF-derived exosomes on the growth of malignant melanoma cells. They found that CAF-derived exosomes express CD9 and CD63 transmembrane proteins, and that the CD9-positive exosomes may inhibit the growth of malignant melanoma cells.

Researchers from Osaka University have found that repeated high-dose treatment, known as pulse therapy, with the steroid methylprednisolone reduces in-hospital deaths in COVID-19 patients who receive invasive mechanical ventilation, but not in patients who don’t receive invasive mechanical ventilation. These findings were only possible using appropriate statistical methods to remove bias from the data, which originally seemed to show that the opposite was true. These results can improve patient treatment and reduce COVID-19-related deaths worldwide.

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in the gene that codes for a specific protein. Tohoku University scientists have uncovered some critical details of this protein’s structure, and the findings could build the foundation for developing treatment for Hailey-Hailey disease and other neurodegenerative conditions.