Medicine & Healthcare Hematology

Researchers from The University of Osaka found that leukemia caused by NUTM1 rearrangements is distinguished from other forms of B-cell acute lymphoblastic leukemia (B-ALL) by a unique pattern of gene activity and gene regulation. Unlike the common form of B-ALL caused by KMT2A rearrangement, which is resistant to treatment, leukemic cells with NUTM1 rearrangements are highly sensitivity to chemotherapy.

Burkitt's lymphoma is a highly aggressive blood cancer that primarily affects children and young adults. It is driven by a genetic alteration involving the MYC gene. Researchers have now developed a novel treatment approach in mice that combines CAR-T cell therapy with limited doses of a SUMOylation inhibitor, which can target MYC. This combination dramatically improved cure rates, paving the way for a potential new treatment strategy for this aggressive cancer.

Combination of venetoclax and azacitidine helps patients with AML who relapse after hematopoietic cell transplant

Gene editing technology has been used to pinpoint new molecular targets for treating an aggressive form of leukemia in adults.

Scientists have developed a prototype sensor that could help doctors rapidly measure adenosine triphosphate (ATP) and lactate levels in blood samples from patients, aiding in the rapid assessment of the severity of some diseases.

Researchers discover a link between an increase in protein Ba of the complement immune system and the eventual development of thrombotic microangiopathy in patients who have received an allogeneic hematopoietic stem cell transplantation.

Residents of Kabwe Town, Zambia, have very high blood levels of lead and cadmium, to such an extent that the symptoms of toxicity have been clinically observed.

Universiti Malaysia Sarawak haematologist Kuan Jew Win is looking for ways to detect certain blood diseases and cancers early.