Peer Reviewed

Gene mutations in acute myeloid leukemia (AML) cells can guide treatment options, and machine learning can rapidly guess the existence of gene mutations based on images of leukemia cells.

Scientists have achieved the first real-time visualization of how “excited-state aromaticity” emerges within just hundreds of femtoseconds and then triggers a molecule to change from bent to planar structure in a few picoseconds. By combining ultrafast electronic and vibrational spectroscopies, the team captured these fleeting structural changes at the molecular level and showed that aromaticity appears before—and then drives—the structural planarization. Their findings lay the groundwork for designing more efficient photoactive materials, such as sensors and light-driven molecular switches, by leveraging the power of aromaticity in excited states.

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, observe the configuration of different dipeptides on graphite electrodes and the subsequent arrangement of catalytic hemin on them to get an idea of the factors affecting its catalytic activity.

Analysis of historical evolution of bureaucracy suggests that quality nation-building holds more importance

Cerebellar rhythm loss due to climbing fiber regression is a shared pathophysiology of motor deficits across cerebellar ataxias.

Scientists develop simplified formulas to quantify quantum entanglement in strongly correlated electron systems

By incorporating gadolinium into a catalyst, its efficiency in a reaction that produces hydrogen fuel increases. This could be the boost we need to lower greenhouse gas emissions.

Researchers at National Taiwan University have unveiled an innovative diagnostic tool that significantly improves the speed and accuracy of detecting bacterial infections.

Researchers from Osaka University found that plasma cells expressing high levels of the protein integrin β7 and the transcription factor KLF2 tend to leave immune tissues and migrate to the bone marrow. There, they become long-lived plasma cells that help create durable antibody responses, which are key to vaccine effectiveness.

To be able to make the switch to environmentally friendly hydrogen fuels, there needs to be a catalyst…or a precatalyst, to be specific!

Coronavirus 229E is the earliest reported human coronavirus (hCoV-229E). Here, the authors used cryo-EM, glycoproteomics, and modeling to generate the atomic structure of fully glycosylated and membrane-bound hCoV-229E spike protein bound to its host receptor, human aminopeptidase N (hAPN).

Researchers from Osaka University analyzed the clinical dental records of a large group of patients with hypophosphatasia (a skeletal disease) to identify its common oral symptoms. Their findings, including early tooth loss, poor oral habits, and disordered swallowing, may help early diagnosis of hypophosphatasia, thereby improving patient treatment and quality of life.

Researchers have developed metal-organic frameworks (MOFs) that efficiently produce hydrogen peroxide (H₂O₂) using small temperature differences, offering a sustainable approach to chemical production.

Soaking up pollutants like a sponge, porous organic polymers (POPs) may be the key to reducing greenhouse gas emissions, according to researchers at Tohoku University.

Hyperspectral imaging and AI can identify individuals using blood vessels in palms

A new framework formulated by SUTD researchers helps ensure digital citizen participation does not just end with feedback collection, but translates into real-world urban decisions.

Scientists have found a way to control electrons in molecules using tailor-made terahertz light pulses, offering new possibilities for advanced technologies.

Until now, when looking for a robot, the choice was between one that was autonomous and cordless, one that enabled high-precision manipulation, and one that could be used in extreme real-world environments. The HB-3 robot is the first that ticks all boxes.

Life-course perspective of households with children

Concurrent steatotic liver disease (SLD) is prevalent among patients with chronic hepatitis B (CHB); however, the effects of the associated cardiometabolic risk factors on all-cause and cause-specific mortality remain unknown. This study demonstrated that cumulative metabolic burden dose- dependently increased the risks of all-cause, liver-related, and cardiovascular mortality in patients with CHB and SLD. Moreover, new-onset diabetes mellitus, hypertension, and weight gain during the follow-up period further exacerbated these risks. However, patients with SLD had a lower risk of mortality than those without SLD. Thus, routine screening and monitoring of metabolic dysfunctions constitute a key element of daily care for patients with CHB.

Researchers at Tohoku University have found one more reason to quit smoking: the inhalation of first-hand and/or second-hand smoke may lead to placental abruption in pregnant mothers.

Researchers at Osaka University show that Cartan's First Structure Equation, which relates to edge and screw dislocations in crystal lattices, can be recast in the same form as a basic mathematical formula that governs the behavior of electric currents and magnetic fields. This work can help make new concepts more understandable by employing more familiar frameworks.

Cryo-electron microscopy reveals molecular structure of twin motors that power mycoplasma’s ability to glide

Researchers from the Institute of Industrial Science, The University of Tokyo, have found a surprisingly simple way of understanding social-distancing behavior during an epidemic.

This study questions recent claims about the rapid effectiveness of psychedelic drugs for treating depression. Among all psychedelics, only high-dose psilocybin showed greater effectiveness than the placebo in antidepressant trials and outperformed escitalopram.

Researchers from Osaka University found that TEX38 and ZDHHC19 co-localize on the plasma membrane of spermatids and mediate S-palmitoylation of ARRDC5, a crucial protein for spermatogenesis. Disrupting either TEX38 or ZDHHC19 inhibited cytoplasm removal from the sperm head, resulting in deformed sperm and infertility in a male mouse model.

Comprehensive screening analysis of organohalogen compounds in blubber samples of 11 toothed whale species stranded on Japanese coasts revealed species-specific accumulation profiles, with a total of over 300 organohalogen compounds detected. For the first time, the composition profiles of marine natural products were found to be useful indicators of the feeding habitats and migration history of individual whale species.

Glaucoma is called the “silent thief of sight” as many don’t notice until significant, irreversible vision loss has already occurred. A revolutionary early screening tool using AI may stop this thief dead in its tracks.

Eight CO2 capture processes were evaluated in terms of economics, environmental impact, and equipment footprint, based on rigorous modeling.

- A pioneer of systems biology who challenged Richard Dawkins’ The Selfish Gene, appointed as the first Chair Professor of DGIST Biomedical Engineering Department opening in March.