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20 Sep 2021
Twisting light that switches direction at room temperature could be the future of quantum information processing.
17 Sep 2021
A research group has successfully used ultra-small testing technologies to measure the coatings on ferritic steel.
After intravenous injection into mice, STING-lipid nanoparticles (red) transported through blood vessels(green) accumulate in the liver (Takashi Nakamura, et al. Journal for ImmunoTherapy of Cancer. July 2, 2021).
17 Sep 2021
A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.
Overview of childhood and adult liver malignancies characterized by molecular aberrations and “cell of origin.”
16 Sep 2021
Genetic and epigenetic profiling of hundreds of hepatoblastoma tumors have revealed many of its secrets, long unknown to those researching and treating what is the most common type of liver tumor in children.
The chemical structure and solids crystals of calix[3]pyrrole (Photo: Inokuma Laboratory).
16 Sep 2021
A new approach leads to the long-awaited formation of rings made of three pyrroles, which could be used to produce compounds with a host of interesting properties, and explains why they have not been observed before.
15 Sep 2021
Using the lamprey, researchers from Japan analyzed the photosensory mechanism of the pineal organ, also called the pineal gland, in non-mammalian vertebrates and discovered a novel mechanism of pineal color discrimination (two-cell system) in which two types of photoreceptor cells, each containing two different opsins, are used to detect color. This discovery may provide insight into the evolution of color detection in other animals, including color vision in humans.
14 Sep 2021
Researchers at Jilin University, China, reviewed recent progress in the study of Salvinia leaves and their artificial replicas.
14 Sep 2021
Researchers from The University of Tokyo assimilated satellite observations of water vapor isotopes into a weather forecasting model and found that forecast accuracy was improved by several percentage points
the optical clearing process of a brain tissue to visualize the 3D vascular network in fluorescence imaging
14 Sep 2021
When it comes to cancer, clarity is key. The ability to visualize cancerous tumors and metastatic tissue three dimensionally (3D) can help clinicians diagnose the precise type and stage of cancer, while also informing the best treatment methods. To obtain an even clearer tissue for imaging, a research team based in Japan has tested the effectiveness of specialized hydrogels. Acting as a 3D molecular network, these hydrogels can rapidly remove fats from tissues, which are a factor in tissue opacification, without losing their structure. The material is used in several biomedical devices, including contact lenses.
IMAGE
13 Sep 2021
iCeMS scientists and colleagues have designed a molecular code that powers up cancer-fighting immune cells.
Shouta M. M. Nakayama (yellow hoodie), Haruya Toyomaki (black polo shirt) and Yared Beyene (blue jacket), along with dogs sampled in the study and the family that owns them (Photo: Shouta M. M. Nakayama).
13 Sep 2021
Abnormally high levels of DNA methylation have been identified in dogs exposed to high levels of lead near a mining area in Kabwe, Zambia, by a team of scientists from Japan and Zambia.
Schematic representation of effects of AHR agonists.
10 Sep 2021
Researchers have identified a potential reason why lower numbers of COVID cases have appeared amongst smokers compared to non-smokers, even as other reports suggest smoking increases severity of the disease.
09 Sep 2021
Researchers succeed in the direct bonding of diamond and gallium nitride (GaN) at room temperature and demonstrate that the bond can withstand heat treatments of 1,000℃, making it ideal for the high temperature fabrication process of GaN-based devices. GaN-on-diamond semiconductor material will allow for the next generation of high power, high frequency devices.
09 Sep 2021
Researchers at the University of Tsukuba in Japan show that low metabolic flexibility is associated with reduced fat metabolism during sleep.
09 Sep 2021
Researchers from the University of Tsukuba and Kyoto University find that capillary blood flow in the brain, which is important for delivering oxygen and nutrients and removing waste products, is increased in mice during the dream-active phase of sleep.
09 Sep 2021
Researchers from University of Tsukuba in collaboration with Yamagata University scientists find that exposure to light with less blue before sleep is better for energy metabolism. Extended exposure to light during nighttime can have negative consequences for human health. But now, researchers from Japan have identified a new type of light with reduced consequences for physiological changes during sleep.
The suggested disease model of multifocal osteomyelitis in MSMD patients
08 Sep 2021
A research team led by Hiroshima University Professor Satoshi Okada has determined that enhanced bone resorption activity due to a faulty immune response may underpin multifocal osteomyelitis — painful, chronic bone infections — in children with MSMD, a rare genetic condition resulting from a range of immune system mutations.
08 Sep 2021
A research group has discovered an interorgan network between the mammary glands and the small intestine that plays an essential role in transferring antibodies via breastfeeding.
07 Sep 2021
Recreating major pathological features of Parkinson’s disease in a lab-grown, human mini-brain will help researchers to explore new treatments. This is the first time that Lewy bodies, a hallmark of Parkinson’s disease in patients’ brains, have been produced in the laboratory, offering new insights into the disease.
06 Sep 2021
A synthetic CDK4/6 inhibitor exerts antitumor effects by forcing RB1 tumor-suppressor into an active status, but its single administration is not sufficiently effective. We find its combinatorial administration with an IKKβ inhibitor is significantly more effective in hepatocellular carcinoma treatment. Also, blockage of the IKK-NF-κB or AKT pathway enhances its effects on RB1-intact K-Ras mutated lung and colon cancers. CDK4/6 inhibitors have potential to treat various RB1-intact cancers when combined with an appropriate kinase inhibitor.
06 Sep 2021
Neuroscientists develop a new approach to better understand the neural mechanism underlying deductive and inductive reasoning
06 Sep 2021
Using data from 1,107 patients dating back over 30 years, researchers have connected prognostic impact to poorly differentiated tumor size in hepatocellular carcinoma. Data confirmed previous findings that after resection, <2 cm sized tumors had excellent long-term outcomes. However, ≥2 cm and ≥5 cm sizes shared a risk of early recurrence with the latter size also at risk of early extrahepatic recurrence.
Masahiro Nakaoka, Rommel Llanillo, Muammar Princess Soniega
03 Sep 2021
Social vulnerabilities of coastal communities and their reliance on blue carbon ecosystem services may be improved by addressing three major factors, according to a study led by Hokkaido University researchers.
Accumulation of POPs-like contaminants in raptors
03 Sep 2021
Knowledge of the detailed accumulation profiles of persistent organic pollutants (POPs) and POPs-like contaminants in wild animals is critical for ecological risk assessment. Comprehensive screening of organohalogen compounds in the livers of wild birds from Osaka, Japan using two-dimensional gas chromatography in combination with high resolution time-of-flight mass spectrometry (GC×GC–HRToFMS) revealed specific accumulation of typically unmonitored POPs-like compounds in raptors.
03 Sep 2021
Carthamin’s usage as dye dates back to ancient Egypt. But scientists only discovered its chemical structure in 2019. Now, a collaborative group of researchers has identified the genes required for the biosynthesis of carthamin.
Researchers find that climate change adaptation brings health co-benefits
03 Sep 2021
The COVID-19 pandemic has increased attention on links between public health and the planet’s health — areas traditionally addressed in separate science and policy circles. Now, an international research collaboration conducted the first comprehensive review of urban climate change responses and potential human health improvements.
02 Sep 2021
Researchers have developed a general quantum algorithm that can directly calculate the energy difference of an atom and molecule using a quantum computer. By avoiding the need to calculate the total molecular energies, the general algorithm is expected to be applied not only to quantum chemical calculations but also to various physical and mathematical problems, which are intractable with nowadays classical computers.
02 Sep 2021
A rapid way to track an elusive part of the immune system will bring better vaccine strategies
01 Sep 2021
KAIST researchers have used whole-genome sequencing to track the development from a single fertilized-egg to a human body.
01 Sep 2021
Scientists from South Korea add foreign atoms to monolayer graphene in a controlled manner to selectively enhance its desirable properties

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