Peer Reviewed

Researchers from Osaka University have shown that deficiency of the protein Favine can lead to accelerated development of atherosclerosis. Loss of Favine in a mouse atherosclerosis model also led to calcification and thrombus development in the blood vessels of the mice. Prior to this, no mouse models for calcification or thrombus formation existed, hindering atherosclerosis research. This work also identifies Favine and its downstream signaling pathway, known as MEF2C-KLF2, as potential therapeutic targets for atherosclerosis.

Researchers from Osaka University have found that the Vibrio cholerae colonization factor TcpF forms a flower-shaped trimer to specifically bind to the minor pilus protein TcpB resulting in secretion by the type 4 pilus secretion system into the extracellular space. This finding could help lead to the development of a novel anti-adhesive drug that selectively interrupts the TcpF-TcpB interaction, which may replace antibiotics in the treatment of cholera.

A new material is set to provide us with faster and higher resolution displays. Hokkaido University researchers could explain what makes this material so special, opening the door to its application and further development.

Researchers from Osaka University have developed a computational analysis tool called CAPITAL for comparative analysis of single-cell RNA sequencing data with complicated branching trajectories. As cells undergo a dynamic process, they can be placed on a “pseudotime trajectory” to analyze the gene expression changes throughout the process. While previously only straightforward linear trajectories could be compared, CAPITAL is proven to be able to accurately compare branching trajectories, significantly advancing the field of high-throughput single-cell sequencing.

Osaka Metropolitan University scientists have created a novel thermoresponsive polymer by adding divalent cations to polymers and water solvents. They also succeeded in controlling thermoresponsive properties by changing the type and mixing ratio of ionic species. This new polymer type is expected to be applied as an analytical reagent for ion-sensing devices and as a material for drug delivery systems.

Puzzling image from the James Webb Space Telescope explained in two new studies

—For acceleration of social implementation of wastewater-based epidemiology—

A study in Japan finds antibody response to the Moderna COVID-19 mRNA vaccine does not vary depending on the time of day when the dose was received.

Osaka University researchers developed a power generation system based on osmotic flow of ions through a membrane riddled with tiny nanopores. By optimizing the size and distribution of the pores, the team demonstrated a way to obtain clean energy from the oceans.

Researchers at The University of Tokyo simulated fractures in amorphous materials due to both cyclic fatigue and constant stress using course-grained dynamics, and demonstrated various failure modes, which can help improve reliability of materials

Osaka Metropolitan University scientists have successfully developed a new positive electrode material Na2FeS2, consisting of sodium, iron, and sulfur. During testing, batteries using the Na2FeS2 positive electrode had a high energy storage capacity and could be charged and discharged for more than 300 cycles. Because the Na2FeS2 is made of abundant inexpensive elements, it is expected to be used in all-solid-state sodium batteries with higher capacity and lower costs.

The SARS-CoV-2 Omicron variant escapes the immune response better than its coronavirus ancestors, but has also facilitated our transition to a society that can live with COVID-19.

- DGIST Professor Jin Ho Chang and Jae Youn Hwang's joint research team revealed for the first time in the world that the depth focused light can be increased by using a bubble layer temporarily created using ultrasound. - The collaborative research of ultrasound and optical imaging experts is expected to overcome the physical limitations of optical imaging and treatment depth.

- Proposing a new decision-making model that adds ‘open innovation,’ the main topic of the 21st century economy, to the existing limited rationality model - Expected to present a practical way to overcome the growth limitations of the modern economic system.

Researchers from Hokkaido University and Toppan have developed a method to detect build-up of amyloid β in the brain, a characteristic of Alzheimer’s disease, from biomarkers in blood samples.

Wear and tear in engines contributes to a lot of wasted fuel and can be dangerous for operators. Now, a collaborative group has created a way to computationally predict wear and tear in piston engines, allowing for enhanced safety measures in automobiles and industrial machinery.

Researchers from Osaka University have found that serum albumin interferes with β2m amyloid fibril formation through macromolecular crowding. Monitoring serum albumin concentrations could therefore help prevent patients from developing dialysis-related amyloidosis, a serious complication of long-term dialysis.

Low concentrations of cetylpyridinium chloride, an antimicrobial agent present in mouthwashes, inhibit the infectivity of four variants of SARS-CoV-2.

Researchers from Osaka University and collaborating partners enhanced DNA detection in silicon nitride nanopores by means of a water–glycerol viscosity gradient. Use of common chemistry under electrochemical flow enabled straightforward detection of individual DNA molecules. With further development, the results of this work could dramatically speed up and lower the cost of genomic sequencing, and facilitate unprecedented integration with compact electronics.

Metastasis—when cancer spreads to form new tumors—causes approximately 90% of cancer-related deaths. Because metastatic cancer cells circulate in the blood, the liver—which filters the blood—is considered the most vulnerable organ, so treatments that prevent liver metastasis are urgently needed. A team of Osaka Metropolitan University researchers discovered a mechanism that allows metastatic cancer cells to infiltrate the liver, and how that infiltration can be blocked by inhibiting a related protein.

Supermassive black holes can launch fast-moving plasma, which emit strong radio signals known as radio jets. Despite being discovered over 40 years ago, much remains unknown about how radio jets are produced. Now, a research team, led by Tohoku University astrophysicists, has attempted to clarify how plasma gets loaded into radio jets.

Osaka Metropolitan University scientists have successfully synthesized 3-hydroxybutyrate, a raw material for poly-3-hydroxybutyrate (PHB)—a strong, water-insoluble, biodegradable plastic used for packaging materials—from acetone and CO2. With a visible light-driven catalytic system utilizing sunlight and two biocatalysts, the researchers achieved a high conversion yield of about 80%. Mimicking natural photosynthesis, this study artificially reproduced a light reaction involving sunlight and a dark reaction fixing CO2 to synthesize the raw material for PHB. The finding is expected to contribute to solving the plastic waste problem and to reducing CO2.

Researchers from Osaka University revealed that the surface electronic structure of topological insulators varies according to its surface atomic structure, even though it was believed to have been protected by the symmetry of the electronic structure inside the crystal and is therefore unaffected by differences in surface atomic structure. This work offers a new means of minimizing the power consumption and increasing the speed of next-generation technology.

A simple and economical method of detecting SARS-CoV-2 viral loads in wastewater with high sensitivity has been developed, expanding the use of wastewater-based epidemiology for tracking the virus in populations.

Research performed on human blastoids, a research model of an early embryo built out of stem cells, may allow scientists to understand better what causes birth defects and lost pregnancies, and so prevent them. But such research is also ethically fraught, warn bioethicists, due to differing beliefs on whether the blastoid possesses sentience or has the potential to do so.

Researchers analyzed how the specific components of peace and environmental sustainability — concepts known to be intrinsically related but often investigated separately — influence each other to better inform policy and decision-making.

Osaka University researchers showed how to use laser beam interference to construct chiral structures. By using computer simulations, they were able to predict the final light pattern and optical radiation force distribution of any collection of light sources. This work may lead to cheaper optical devices and sensors.

Scientists have pinpointed a protein in lysosomes that is involved in recycling a crucial fatty component of cell membranes to keep cells healthy.

- The low-cost, high-energy, long-life lithium-sulfur battery is based on a novel silica/sulfur interlayer. - The battery is expected to be used in next-generation mobile phones, drones, and electric vehicles owing to its high energy density and improved lifespan.

- A research team led by Professor Lee Sungwon from DGIST succeeded in developing the world’s first mesh (nanomesh) structured electronic skin device (organic field-effect transistor) - An electronic skin device comprising only a mesh (nanomesh) structure that can measure and process bio-signals for a prolonged period indicates a big step toward integrated systems for electronic skin devices.