Peer Reviewed

The complete set of nucleobases found in terrestrial DNA and RNA have been detected in samples returned from the asteroid Ryugu, offering insights into the early Solar System's chemistry.

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect strategy to counter KRAS-driven malignancy without direct KRAS targeting.

Through protein binding, molecular heavy drugs are effectively transported to cancerous tissues

- Research team led by Jae Eun Jang and Goeun Pyo demonstrates stable “dual-modulated vertically stacked transistors” even with two-dimensional nanochannels - Enables large-area and multilayer scalability without costly ultra-precision fabrication processes, which is promising for high-density 3D chips and flexible devices - Published in the leading international journal Advanced Science

- Breaking through the limitations of conventional oxygen-defect-based memories... Simultaneously performing AI computation and storage through precise hydrogen atom control - First case of successfully controlling hydrogen in a two-terminal vertical structure, accelerating the era of ultra-low-power, high-density neuromorphic chips - Selected as cover paper for the prestigious international journal ACS Applied Materials & Interfaces

Researchers discovered that a freshwater alga captures low-energy far-red light by precisely arranging ordinary chlorophyll molecules, rather than inventing new pigments. The finding reveals a new structural strategy for photosynthesis in low-light environments and could inform future bioenergy and protein design.

This invited publication highlights the contributions of Distinguished Professor Hao Li to AI and materials science – focusing on their original concept for a digital materials ecosystem.

Researchers used electroluminescence-detected magnetic resonance to directly observe electron-hole pairs in operating light-emitting electrochemical cells. They found that ion-driven changes in the internal electric field strongly affect recombination efficiency. Lower-voltage, more stable electric fields promote light emission, a discovery that identifies electric field management as a key factor in improving organic optoelectronic devices.

A Taiwan-oriented study in Gut shows that gastric cancer is shaped by complex interactions between environmental exposure, microbes, host, and tumor biology. The findings reveal distinct cancer routes and targets linked to prognosis and potential treatment opportunities.

By placing single-atom-thick adlayers of p-block metals on commonly employed gold electrodes (d-block), a research team at National Taiwan University has successfully quantified the "interfacial hopping integral" between molecules and electrodes. This new model establishes a universal descriptor to predict conductance trends in single-molecule junctions, resolving long-standing variations in molecular measurements.

Researchers from Institute of Industrial Science, The University of Tokyo develop a mutual information estimator capable of accurately measuring information flow to biological outputs without needing input quantities

Researchers found that Y-doping (adding yttrium) to an inexpensive nickel catalyst was the key to speeding up an otherwise sluggish reaction that results in hydrogen – which can be used as a sustainable fuel.

The famed Japanese green tea powder may suppress nerve activity associated with sneezing in hay fever, according to a study in mice.

Changes in male hormones and excessive sugar intake work together in progressing liver damage

Wearable medical devices, like exoskeletons, often rely on soft actuators, materials that convert electrical energy into motion. But traditional actuators often use stiff metallic materials that limit mobility. Now, an international research group has developed soft yarn actuator fibers that can bend, contract, and produce complex movements when electricity is applied.

Observations of the Rimae Bode region on the Moon reveal five distinct types of terrain and identify several potential landing sites for China’s first crewed mission, according to research published in Nature Astronomy.

About 40% of East Asians suffer from alcohol intolerance, known as “Asian Flush Syndrome,” caused by an ALDH2 genetic mutation. Beyond facial flushing, this mutation carries serious cardiovascular risks. Carriers experience more severe heart damage during heart attacks, though the mechanism was unclear. A study led by Professor Yin Huiyong at City University of Hong Kong, published in Circulation, reveals that ALDH2 triggers ferroptosis—a form of cell death—during myocardial infarction. This accelerates cardiac tissue deterioration, explaining the heightened vulnerability. The discovery not only solves a long-standing mystery but also opens new avenues for precision prevention and treatment for millions worldwide.

Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to distant organs. Their study shows that cancer cells stimulate Wnt signaling in surrounding stromal fibroblasts to produce hyaluronan, creating a supportive microenvironment that promotes metastasis. These findings provide new insight into how metastatic tumors establish themselves and suggest promising strategies to prevent gastric cancer progression.

HBsAg seroconversion, durable HBsAg loss, and the presence of anti-HBs are considered indicators of an almost complete cure of chronic HBV infection, which is viewed as a goal that is rarely achieved with current antiviral treatments. Researchers from the College of Medicine of National Taiwan University and National Taiwan University Children’s Hospital identified that the undetectable circulating HBV RNA after HBeAg-seroconversion is an important predictor of HBsAg seroconversion.

A team of researchers from Taiwan has developed PanMETAI, an AI-powered platform that analyses metabolic fingerprints in a simple blood sample to detect pancreatic cancer at its earliest stages—when treatment is most effective—achieving up to 94% diagnostic accuracy.

Testing air and surfaces can detect dangerous viruses earlier and more comprehensively than testing birds alone

The oldest-known articulated bony fish and an early example of teeth from a bony fish have been detected in a collection of fossils from China. Two Nature papers offer new insights into the origins of bony fish.

A new study from Hiroshima University showed that, among university students just entering the workforce, those with optimism about the future better manage 'reality shock' through formation of a career-related identity.

- Breakthrough in solar hydrogen production efficiency of heavy-metal-free eco-friendly quantum dots through anion defect control - Demonstrates commercialization potential of sustainable energy transition materials; published in the international journal eScience

- Mechanism of brain neuropeptide circuit reconstruction uncovered, paving the way for next-generation rapid-acting therapies beyond serotonin - Findings published in Molecular Psychiatry, a leading journal in molecular psychiatry

- Joint research team of DGIST and KBSI developed precision protein analysis technology to identify causes of intractable diseases - Presented a new analytical horizon for developing treatments for neurodegenerative and metabolic diseases, such as dementia, Parkinson’s disease, and diabetes - Developed an innovative analytical method for structural analysis of proteins lacking Specific 3-dimensional structures

Researchers from The University of Osaka have found that potassium KCNQ2/3 channels in the brain, which are important for suppressing cell excitability, need to be fully functional to be trafficked to the appropriate part within the nerve cell and work properly. This link between channel functionality and localization may have important consequences for the development of therapies against KCNQ2/3-related epilepsy.

What’s going on in there? An international research team developed a method to pull back the veil on the unknown processes going on inside quantum computers - which may help us build more reliable quantum machines.

The development of a precision positioning robot with unhindered motion can be a huge step forward for medical procedures, microfabrication, and more.

Diastereomers are molecules with identical structures that are not mirror images of each other, described as anti or syn for molecules without rings. Researchers at The University of Osaka developed a strategy for using a rigid cage-like molecule to produce an anti-diastereomer in high yield. This diastereomer can only be obtained as a minor byproduct by traditional methods. The strategy is expected to become a key technology for making medicines and other bioactive substances.