Peer Reviewed

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.

Osaka University researchers investigated the physics of laser-driven neutron sources, and found the relationship between the power and the neutrons generated. They were able to decrease the exposure time needed for neutron absorption experiments, which may be employed in biomedical research.

The study is an important step towards the understanding of long-term changes in the water cycle and will aid in more informed decisions when assessing and managing regional water systems.

A research group at the Osaka Metropolitan University Graduate School of Informatics has developed a new learning method for artificial intelligence that combines classification performance for data with multiple labels with the ability to learn continually from data. Numerical experiments on real-world multi-label data indicate that the new method outperforms conventional approaches. The simplicity of this algorithm makes it easy to integrate it with other algorithms to devise new ones.

Data stored in ice cores dating back 55 years bring new insight into atmospheric levels of a molecule that can significantly affect weather and climate.

Researchers from Osaka University have shown that a system known as the GET pathway is essential for efficient mitophagy, the process by which mitochondria are removed from cells. The GET pathway targets a protein assembly called the Ppg1–Far complex, which inhibits mitophagy, to the membrane of a part of the cell called the endoplasmic reticulum. When the GET pathway is defective, this complex instead becomes targeted to mitochondria, where it acts to suppress mitophagy.

Researchers from Osaka University compared the sensitivity of rapid antigen tests (RATs) and polymerase chain reaction (PCR) tests for the Omicron variant of COVID-19 using data produced by the Japan Professional Football League. They found the comparative sensitivity of RATs for Omicron was not affected by the duration from the onset of symptoms to testing.

Everyday electronics, such as our phones, employ surface acoustic wave devices for frequency filtering and sensing. But this consumes a lot of energy, serving as a drain on battery life. Now, a team of researchers has developed a new acoustic waveguide based on the mathematical concept of topology, which will help alleviate this problem.

A “back-projection” technique reveals new details of the volcanic eruption in Tonga that literally shook the world.

New research found that periodontitis, a common gum infection known to worsen other systemic diseases, could also be linked to atrial fibrosis — potentially clarifying its previously unknown connection with atrial fibrillation.

Researchers from Osaka University have identified a protein, FER1L5, that is essential for sperm to acquire fertilizing ability. Sperm from mice lacking this protein were unable to undergo the “acrosome reaction”, which releases molecules that facilitate fertilization, resulting in impaired male fertility. As FER1L5 is also present in human sperm, this work may lead to new diagnostic methods and treatments for male infertility in humans.

Osaka Metropolitan University scientists have succeeded in synthesizing fumaric acid, a raw material for plastics, from CO2 powered by solar energy—for the first time. Typically, fumaric acid is synthesized from petroleum as a raw material to make polybutylene succinate, a biodegradable plastic, but this research shows that it can be synthesized from CO2 and biomass-derived compounds using renewable energy.

Researchers from Osaka University created a bound state of a proton and a K- meson known as Λ(1405), and measured its mass. The data implied that it consisted of five quarks. This work may help scientists develop a theory of exotic matter that existed in the early Universe or in neutron stars.

A research group, at the Osaka Metropolitan University Graduate School of Engineering, has succeeded in measuring spin transport in a thin film of αNPD molecules—a material well-known in organic light emitting diodes—at room temperature. They found that this thin molecular film has a spin diffusion length of approximately 62 nm, a length that could have practical applications in developing spintronics technology. In addition, while electricity has been used to control spin transport in the past, the thin molecular film used in this study is photoconductive, allowing spin transport control using visible light.

New research from Osaka University indicates that more screen time at age 2 is associated with poorer communication and daily living skills at age 4—but when kids also play outdoors, some of the negative effects of screen time are reduced. Increasing outdoor play time could reduce the negative effects of screen time on daily living skills by almost 20%.

The natural abilities of squid tissues and the creativity of chemists combine to take hydrogel research in new directions.

Imagine if your t-shirt could take your sweat and analyze it for health abnormalities. Well, this is much closer to reality after a recent breakthrough by a research group led by a Tohoku University assistant professor. The group created the first microelectronic fiber with microscopic parameters that is capable of analyzing electrolytes and metabolites in sweat.

Controlling a material’s thermal conductivity can help insulate our homes, improve the performance of electronic devices, conserve power consumption in cars, and generate greater power efficiency. Now, a group of researchers has unveiled a novel mechanism that leads to further suppression of thermal conductivity in thermoelectric materials, something that will help develop new guidelines for producing high-performance thermoelectric materials.

Understanding how dust grains form in interstellar gas could offer significant insights to astronomers and help materials scientists develop useful nanoparticles.

Magnesium hydride has long been touted for its potential to store large amounts of hydrogen, something essential if hydrogen is to play a role in powering a sustainable future. Yet, sluggish dehydrogenation kinetics and the high temperature required to decompose and produce hydrogen from the material have stymied its use. Now, researchers have identified why this is so, paving the way for future design guidelines and widespread commercial use.

A team including Kavli IPMU has studied the relation between galaxy size and luminosity of some of the earliest galaxies in the universe taken by the James Webb Space Telescope, less than a billion years after the Big Bang.

Researchers led by Osaka University demonstrated the role of endothelial cell-specific protein Roundabout4 (Robo4) in the reduction of vascular permeability and mortality in mouse models of severe infection. The research team identified a drug inhibitor that increased Robo4 expression and reduced mortality in sepsis and SARS-CoV-2 mouse models of infection. These findings may aid in the development of drugs to reduce the mortality rate of severe infectious diseases.

An Osaka Metropolitan University research group recorded the autonomic nervous system activity in patients with irritable bowel syndrome (IBS) and healthy subjects using a wearable device and a proprietary smartphone application to record daily life events such as defecation and sleep. As a result, they found that sympathetic nervous system activity was activated in IBS patients from 2 minutes before defecation and continued until 9 minutes after defecation. Further research is expected to improve the quality of life of IBS patients and elucidate the pathophysiology.

A team of Japanese researchers created a high-quality genome assembly of red perilla, a step toward harnessing the plant’s potentially useful bioactive chemicals — and its medicinal properties.

Osaka Metropolitan University scientists delved into the relationship between gait function and knee extension velocity after total knee arthroplasty and compared the effects of various factors on walking. The results reveal that knee extension velocity, measured while seated, on the operated side was the most important determinant of gait function. These findings are expected to contribute to the development of new rehabilitation programs for efficient gait function improvement.

An Osaka Metropolitan University research team analyzed the regulatory mechanisms of carbohydrate-hydrolyzing enzyme production in Aspergillus aculeatus, a filamentous fungus that produces enzymes with an excellent ability to degrade plant biomass. The team found that UDP-glucose 4-epimerase (Uge5), an enzyme known for its involvement in galactose metabolism, also regulates the expression of degrading enzyme genes in A. aculeatus. This is the very first report of Uge5’s roles in selective gene expression in response to different types of inducing sugars in filamentous fungi.

A research group at Osaka Metropolitan University has succeeded in significantly reducing the measurement time of a glass standard sample by applying Bayesian estimation to X-ray fluorescence analysis. The ability to perform rapid non-contact elemental analysis in a nondestructive manner could lead to the widespread use of this technique in many fields, including the analysis of moving industrial products and waste materials while being carried on conveyor belts.

Researchers at Hokkaido University have revealed the effects of high pathogenicity avian influenza virus infection on an Ezo red fox and a Japanese raccoon dog, linking their infection to a recorded die-off of crows.

Researchers at The University of Tokyo simulate the phase separation of self-spinning particles, and show that the process differs from other unmixing processes, which may shed light on the organization of bacteria and other organisms

A research study led by scientists from the School of Chinese Medicine (SCM) at Hong Kong Baptist University (HKBU) has shown for the first time that the human gut bacterium Ruminococcus gnavus is a major trigger factor of diarrhoea-predominant irritable bowel syndrome (IBS-D). Based on this discovery, a new therapeutic target for the disease’s treatment was identified. The study also found that low-protein food items such as fresh fruits, vegetables and bread may help reduce the gut motility in IBS-D.