Dr. Anthony Tanoto Tan

Dr. Anthony Tan is actively involved in clinical trials in Singapore and China to test the safety and efficacy of adoptively transferring T cells engineered against HCC with HBV integration in collaboration with Lion TCR Pte Ltd.

He is currently a Senior Research Fellow in the Emerging Infectious Diseases Programme at the Duke-NUS Medical School Singapore.


PhD (Faculty of Medicine), National University of Singapore (2012)
Bachelor of Science, National University of Singapore (2007)

Research Interests

Understanding the pathogenesis and immune response against Hepatitis B Virus (HBV) infection.
Development of T cell-based immunotherapy approaches against chronic HBV infection and HBV-related hepatocellular carcinoma (HCC).


Selected publications

Nina Le Bert, Hannah E. Clapham, Anthony T. Tan, Wan Ni Chia, Christine Y.L. Tham, Jane M. Lim, Kamini Kunasegaran, Linda Wei Lin Tan, Charles-Antoine Dutertre, Nivedita Shankar, Joey M.E. Lim, Louisa Jin Sun, Marina Zahari, Zaw Myo Tun, Vishakha Kumar, Beng Lee Lim, Siew Hoon Lim, Adeline Chia, Yee-Joo Tan, Paul Anantharajah Tambyah, Shirin Kalimuddin, David Lye, Jenny G.H. Low, Lin-Fa Wang, Wei Yee Wan, Li Yang Hsu, Antonio Bertoletti, Clarence C. Tam; Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection. J Exp Med 3 May 2021; 218 (5): e20202617. doi: https://doi.org/10.1084/jem.20202617

Tan AT, Linster M, Tan CW, et al. Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients. Cell Reports. 2021 Feb;34(6):108728. DOI: 10.1016/j.celrep.2021.108728. PMID: 33516277; PMCID: PMC7826084.

Hafezi, M., Lin, M., Chia, A., Chua, A., Ho, Z. Z., Fam, R., Tan, D., Aw, J., Pavesi, A., Krishnamoorthy, T. L., Chow, W. C., Chen, W., Zhang, Q., Wai, L. E., Koh, S., Tan, A. T., & Bertoletti, A. (2021). Immunosuppressive Drug-Resistant Armored T-Cell Receptor T Cells for Immune Therapy of HCC in Liver Transplant Patients. Hepatology (Baltimore, Md.), 74(1), 200–213. https://doi.org/10.1002/hep.31662

Tham CYL, Kah J, Tan AT, et al. Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes. Cell reports. Medicine. 2020 Jul;1(4):100060. DOI: 10.1016/j.xcrm.2020.100060. PMID: 33205065; PMCID: PMC7659593.

Le Bert, N., Tan, A. T., Kunasegaran, K., Tham, C., Hafezi, M., Chia, A., Chng, M., Lin, M., Tan, N., Linster, M., Chia, W. N., Chen, M. I., Wang, L. F., Ooi, E. E., Kalimuddin, S., Tambyah, P. A., Low, J. G., Tan, Y. J., & Bertoletti, A. (2020). SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature, 584(7821), 457–462. https://doi.org/10.1038/s41586-020-2550-z

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