Dr. Iyaswamy Ashok
Education
Postdoctoral training, School of Chinese Medicine of Hong Kong Baptist University (2020)
Ph.D in Physiology and Neuroscience, Institute of Basic Medical Science, University of Madras (2015)
M.Sc, University of Madras (2007)
B.Sc, Madurai Kamaraj University (2005)
Research Interests
Understanding the molecular mechanisms and pathophysiology of Alzheimer’s disease and other neurodegenerative diseases.
Developing potential methods for brain drug delivery system and biomaterials for diagnosis of neurodegenerative diseases.
Identifying possible benefits of Chinese herbal medicine for prevention and treatment of neurodegenerative diseases.
Selected publications
Yang CB¶, Su CF¶, Iyaswamy A¶, Krishnamoorthi SK¶, Zhu Z, Yang S, Tong BCK, Liu J, Sreenivasmurthy SG, Guan X, Kan Y, Wu A J, Huang A S, Tan JQ, Cheung KH, Song JX, Li M*. (2021) Celastrol Enhances Transcription Factor EB (TFEB)-mediated Autophagy and Mitigates Tau Pathology: Implications for Alzheimer's Disease Therapy. Acta Pharmaceutica Sinica B (Co-first author)
Sreenivasmurthy SG¶, Iyaswamy A¶, Krishnamoorthi SK, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BCK, Cheung KH, Tan JQ, Lu JH, Durairajan SSK*, Song JX*, Li M.* (2021) “ Protopine promotes the proteasomal degradation of pathological tau in Alzheimer’s disease models via HDAC6 inhibition”. Phytomed. 6 Dec. 2021(Co-first author)
Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Wang ZY, Cheung KH, Song JX*, Durairajan SSK* & Li M* (2021) “ Qingyangshen mitigates Amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease”. Phytomed. 3 July 2021. doi:10.1016/j.phymed.2021.153648
Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammella AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY*, Durairajan SSK* & Li M*. (2020) “Yuan-Hu Zhi Tong Prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of Alzheimer’s disease”. Frontiers in Pharmacology, 25 Sept. 2020. doi: 10.3389/fphar.2020.584770, PMID: 584770
Iyaswamy A, Krishnamoorthi Senthil K, Song JX, Yang CB, Kaliyamoorthy V, Sreenivasmurthy SG, Wang ZY, Malampati S, Durairajan SSK, Li M.*(2020) “ NeuroDefend, a novel traditional Chinese medicine, attenuates amyloid-beta and tau pathology in experimental Alzheimer's disease models.” J. Food and Drug Analysis 2020 Jan; 28(1):132-146. doi: 10.1016/j.jfda.2019.09.004. Epub 2019 Oct 8. PMID: 31883601
