Brain

News

15 Sep 2021
New research published in Stem Cell Reports has found elevated cholesterol supply from astrocytes to neurons in the model of Alzheimer's disease (AD) brains, suggesting that modulating brain cholesterol could be explored in the search of treatment options for the devastating, degenerative disease.
09 Sep 2021
Researchers from the University of Tsukuba and Kyoto University find that capillary blood flow in the brain, which is important for delivering oxygen and nutrients and removing waste products, is increased in mice during the dream-active phase of sleep.
07 Sep 2021
Recreating major pathological features of Parkinson’s disease in a lab-grown, human mini-brain will help researchers to explore new treatments. This is the first time that Lewy bodies, a hallmark of Parkinson’s disease in patients’ brains, have been produced in the laboratory, offering new insights into the disease.
06 Sep 2021
Neuroscientists develop a new approach to better understand the neural mechanism underlying deductive and inductive reasoning
12 Aug 2021
Experiments conducted on genetically modified mice clarify the role of a protein in regulating properties of specific hippocampal neural circuits
10 Aug 2021
A new, energy-efficient method of electrical brain stimulation developed by researchers from the Daegu Gyeongbuk Institute of Science and Technology could aid stroke rehabilitation and has few side effects.
12 Jul 2021
- Gowoon Son, DGIST, to earn a Doctorate from Maastricht University
08 Jul 2021
Our brain has no lymphatic system; however, it does have fluid flow, which is believed to play a role in removing waste from the brain. However, the fluid's point of origin and fluid flow is still unclear. The “multi-scale stable isotopes imaging” project in Hokkaido University aims to solve this mystery using advanced technology. “We would not have been able to perform this study without Hokkaido University’s MRI technology and the isotope microscope,” said the project’s PI, Professor Kohsuke Kudo of the Department of Radiology, Faculty of Medicine.
08 Jul 2021
ARN's July newsletter features research about a promising treatment candidate to reverse dementia, a newly discovered climate pattern, using starch in tiny energy devices, exploring earth Earth ecosystems and the photo of the month.
17 Jun 2021
Cryo-electron microscopy and computer simulations uncover how a cellular protein helps transport omega-3 fatty acids to the brain and eye, with implications for drug development.
Infants could identify two faces when the temporal interval between them was 800 ms, but they could identify only the first target (overlooked the second target) when the separation was 200 ms, thus demonstrating the attentional blink
21 May 2021
Chuo University and Hokkaido University researchers have found that infants take less than a second to completely process visual information and have the same temporal limitation in processing visual information as seen in adults.
Plaque-eating microglia
21 May 2021
Single-cell gene studies are clarifying the roles of the brain’s specialised immune cell in Alzheimer’s disease and offer new avenues for treatment of this incurable condition.
09 Apr 2021
ARN's April Newsletter features research on COVID-19 antibodies, cancer-fighting hydrogels, how the brain organizes information, the 'poor man's q-bit' and the photo of the month!
26 Mar 2021
An ‘eat-me’ signal displayed on cell surfaces requires activation of a lipid-scrambling protein by a nuclear protein fragment.
19 Mar 2021
Through a series of prosocial choice tasks, researchers reveal prosocial and antisocial characteristics in male convict cichlid fish. The fish distinguish between female breeding partners, unknown females, and rival males by adjusting their actions to either provide food for both them and the females or avoid providing food for the rival males.
10 Mar 2021
Researchers reveal the path of information received by the hippocampus. Using optogenetics during large-scale recordings of rat subiculum, they discovered that the subiculum distributes information from the hippocampus to 4 downstream regions of the brain. They observed that the theta and sharp-wave/ripples in the subiculum controlled information transmission with millisecond precision according to the target region. This provides the foundation for a comprehensive understanding of the hippocampal memory system.
03 Mar 2021
Osaka City University finds that the chemical sesaminol, naturally occurring in sesame seeds, protects against Parkinson’s disease by preventing neuronal damage that decreases the production of dopamine. In vitro experiments show sesaminol handle oxidative stress in cells by regulating the production of reactive oxygen species and the movement of antioxidants. In vivo experiments reveal that a diet of sesaminol increases production of dopamine and significantly improve motor functions in mice.
28 Feb 2021
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease (MJD), describes the most common form of dominantly inherited ataxia in many populations worldwide, including Hong Kong and mainland China. SCA3 or MJD patients often present problems with gait and balance, blurred vision, and speech difficulties. The symptoms are progressive, and patients may eventually decline into a bed-ridden state. To date, SCA3 or MJD remains an incurable disorder. Collaborating with the University of Oxford, Professor Ho Yin Edwin Chan’s research team from the School of Life Sciences of The Chinese University of Hong Kong (CUHK) recently unveiled the counteracting relationship between pre-mRNA-processing factor 19 (Prpf19) and exocyst complex component 7 (Exoc7) in controlling the degradation of disease protein and neurodegeneration of the rare hereditary ataxia. The research findings have been published in the prestigious scientific journal, Cell Death & Disease.
25 Feb 2021
New study shows that uneven accumulation of amyloid β is linked to olfactory dysfunction or partial loss of smell, an early symptom of Alzheimer’s disease
24 Feb 2021
Scientists have revealed glial cells act as amplifiers for synaptic signals and artificial control of the glial state can potentially be used for enhanced memory function of the brain.
24 Feb 2021
A research team from the School of Life Sciences at The Chinese University of Hong Kong (CUHK) has recently discovered that SOX9 protein is an essential regulatory factor of choroid plexus function that ensures the correct composition of cerebrospinal fluid (CSF). The finding, recently published in the prestigious scientific journal Proceedings of the National Academy of Sciences of the United States of America (PNAS), has provided the scientific community a novel understanding to the molecular regulatory mechanisms behind the function of the blood-CSF barrier and lays the groundwork for developing novel therapeutic strategies for preventing and treating neurodevelopmental disorders.
11 Feb 2021
Research co-led by academics at City University of Hong Kong (CityU) has discovered that the phenomenon of human self-organisation known as synchronisation forms spontaneously to avoid inter-person collisions when the safety distance between pedestrians seems insufficient. The findings provided insights in preventing pedestrian synchronisation-induced wobbling effect in structures, ensuring pedestrian and transportation safety.
When quiescent neural stem cells in the fruit fly larval brain are activated, they can generate new neurons. In the image, the nucleus of quiescent neural stem cells is labelled by a marker of neural stem cells named Deadpan in magenta, and the cell outline is marked in green.
11 Feb 2021
A brain enzyme activates dormant neural stem cells, revealing how defects in its gene could lead to neurodevelopmental disorders.
03 Feb 2021
Researchers from the School of Chinese Medicine (SCM) at Hong Kong Baptist University (HKBU) have developed a Chinese medicine formula named NeuroDefend that offers a potential novel treatment for Alzheimer’s disease (AD). Mouse model experiment results showed that the formula reduces the levels of amyloid-beta (Aβ) and insoluble hyperphosphorylated-tau protein, which are the major hallmarks of AD, in mice brains. It also improves cognitive function and memory in mice.
19 Jan 2021
Autism has a higher prevalence in males than females. Bisphenol A (BPA) is a common chemical found in plastics, our food, and even the human placenta. Higher prenatal exposure to BPA is thought to increase the risk of autism. Researchers have, for the first time, identified autism candidate genes that may be responsible for the sex-specific effects of BPA.
24 Dec 2020
Researchers at Tohoku University have developed the first all-in-one miniature pH probe for real-time investigations of intrinsic extracellular pH dynamics in the deep brain structures.
New IRAK4 mutations discovered
21 Dec 2020
Researchers baffled by an infant’s rare encephalitis case unusual in children found unheard-of mutations and a new way to examine the “immunity gene.”
16 Dec 2020
Daegu Gyeongbuk Institute of Science and Technology (DGIST) researchers gain deeper insight into a cell membrane channel, with potential implications for drug development.
16 Dec 2020
A research team used next-generation sequencing to illustrate the possible molecular mechanisms that cause the Fragile X syndrome in fetal brains.
15 Dec 2020
An AI might soon help stroke survivors get the right treatment by detecting a patient’s post-stroke depression type, a frequently seen neuropsychiatric manifestation after a stroke that could impair functional recovery.

Events

10 Mar 2021
Upcoming side event at the 7th Asia-Pacific Climate Change Adaptation Forum: Partnerships to harmonize science information and knowledge at regional scales for enabling adaptation
The Khwarizmi International Award (KIA) acknowledges the efforts made by researchers, innovators and inventors from across the globe and to appreciate their high quality research work and contributions to different fields of science and technology.

Researchers

Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Picture of Prof. Jinsoo Seo
Prof. Jinsoo Seo's research focuses on mechanisms of cellular dysfunction and cognitive decline in aging brain, genetic risk factors for neurodegeneration as well as the effect of environmental factors and lifestyle on Alzheimer's disease.
City University of Hong Kong (CityU)
Picture of Prof. Jan Schnupp
Prof. Jan is interested in how sensory processing interpret auditory inputs to the brain are transformed to underpin subjective perceptual qualities of sound such as pitch, timbre and sound source location, and how the brain learns to adapt to the statistical structure of the sounds in our environment to form efficient neural representations of sound and to support auditory scene analysis.
Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Picture of Hyeon- Ae Jeon
Prof. Hyeon- Ae Jeon is a principal investigator of Partner Group of the Max Planck Institute for Human Cognitive and Brain Sciences at the Department for Brain and Cognitive Sciences, DGIST.
Hong Kong Baptist University (HKBU)
Picture of Ken Yung Kin-Lam
Professor Ken's current research mainly focuses on the causes and treatments of neurodegenerative diseases. His lab has developed a nanomaterial-based technology for harvesting autologous neural stem cells from the brain of living subjects.
Dr. Indika, Neluwa-Liyanage is a lecturer at the Faculty of Medical Sciences of University of Sri Jayewardenepura. His research focuses on pathogenesis and metabolic profile of autism spectrum disorder. He has also collaborated actively with international researchers in the field of inherited metabolic disorders.
Universiti Malaysia Sabah
Dr. Connie Cassy Ompok is an early childhood education expert and a Senior Lecturer at the Faculty of Psychology and Education, Universiti Malaysia Sabah. She Started her career in Early Childhood Education as a preschool teacher (2004-2007), a lecturer in early childhood education at the Malaysian Institute of Teacher Education (2008-2016) before serving as a Senior Lecturer in Early Childhood Education at UMS (2016 until now).
Korea Advanced Institute of Science and Technology (KAIST)
Greg Seong-Bae Suh is an associate professor in the Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST).
University of Malaya
Picture of Durriyyah Sharifah Hasan Adli
The Neuroscience Research Group is a multi-disciplinary team investigating the nervous system. They are focusing on animal behavioral models for memory in the laboratory. They are studying the effects of food, such as Habbatus Sauda/Black cumin (Nigella sativa) and honey, on brain microstructures and memory. They also compare Islamic and neuroscience perspectives on issues like learning and sleep for children with and without autism spectrum disorders.
Prof Yow is the Associate Head of the Humanities, Arts and Social Sciences at Singapore University of Technology and Design (SUTD) and leads the SUTD Language and Social Cognition Lab where they look at how language impacts on our cognitive functioning and understanding of the social world. Her research focuses on exploring and studying patterns of dual language use, how language environment may influence how children perceive communicative cues and how technology influences the way we communicate, and how it can be harnessed in ways that can improve or slow down the decline of cognition and social cognition.
Nanyang Technological University
The prospect of favorably influencing brain health through dietary habits has gained much interest. My research interest explores the therapeutic potential of functional foods and phytonutrients as neuroprotectants against mitochondrial diseases and cerebral toxoplasmosis. The scientific findings support nutritional intervention as a viable strategy for the management of human brain disorders.
Hira Khalid is an associate professor at the Department of Chemistry of Forman Christian College University, Lahore, Pakistan.
Duke-NUS Medical School
Prof. Wang Hongyan is the deputy programme director and principal investigator of the laboratory of Neural Stem Cell at Duke-NUS Medical School, Singapore.
International Islamic University Malaysia (IIUM)
Ramzi is an Assistant Professor at International Islamic University Malaysia (IIUM).
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Solving the mystery of sleep ~Developing new intervention methods for healthy slumber~
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Mechanisms of sleep and memory, and their disease models
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Takeshi Sakurai is a professor at the International Institute for Integrative Sleep Medicine, University of Tsukuba, Japan.
Tohoku University
We investigate the brain through visual functions to apply the knowledge to human engineering and image engineering.
Tohoku University
Viteroretinal surgeon working on developing treatments for retinal dystrophies and many other retinal diseases.
Kanazawa University
Dept of Medical Neuroscience, School of Medicine, Kanazawa University
A robotics scientist focused on innovating robotic devices for interventions requiring magnetic resonance imaging (MRI) guidance, e.g. stereotactic neurosurgery and cardiac catheterization.
Universiti Teknologi MARA (UiTM)
Kartini Ilias is a senior lecturer and clinical psychologist in Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, Selangor.
Korea Advanced Institute of Science and Technology (KAIST)
Professor in Electrical Engineering at Korea Advanced Institute of Science and Technology (KAIST).
Prof. Dr. Francisco J. Barrantes is the Head of the Laboratory of Molecular Neurobiology, BIOMED UCA-CONICET, Buenos Aires, Argentina.
Kyoto University
Gen’s research field is the electrical- and optical- physiology.
Kyoto University
Masanori Shimono is an associate professor at Kyoto University Graduate School of Medicine.
National Institute for Materials Science (NIMS)
Current: Deputy and Administrative Director & Principal Investigator of International Center for Materials Nanoarchitectonics (WPI-MANA) . Professor at the Graduate School of Pure and Applied Sciences, University of Tsukuba
The Chinese University of Hong Kong (CUHK)
Professor, School of Life Sciences, The Chinese University of Hong Kong
Hokkaido University
Toru Kondo is Professor of the Division of Stem Cell Biology at the Institute for Genetic Medicine, Hokkaido University.