Dr Koji Nishiguchi

Viteroretinal surgeon working on developing treatments for retinal dystrophies and many other retinal diseases.

Education
1991 – 1997: School of Medicine, Nagoya University, Nagoya, Japan
2001 – 2005: Graduate School of Medicine, Nagoya University, Nagoya, Japan

Employment
2014 - Present:Associate Professor,Tohoku University Graduate School of Medicine
2012 - 2013: Clinical Research Associate, UCL, Institute of Ophthalmology
2011: Research fellow, Department of Medical Genetics, University of Lausanne
2007 – 2011: Assistant professor of Ophthalmology, Nagoya University School of Medicine
2002 – 2004: Research Fellow in Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Harvard Medical School
2000 - 2001: Research Fellow, Schepens Eye Research Institute, Harvard Medical School
1999 – 2005: Resident, Ophthalmology, Nagoya University Hospital, Japan
1997 – 1999: Resident of General Medicine/Emergency Medicine, Nagoya Daini Red Cross Hospital

Selected publications

1: Sato T, Nishiguchi KM, Fujita K, Miya F, Inoue T, Sasaki E, Asano T, Tsuda S,
Shiga Y, Kunikata H, Nakazawa M, Nakazawa T. Serum anti-recoverin antibodies is
found in elderly patients with retinitis pigmentosa and cancer. Acta Ophthalmol.
2020 Feb 11. doi: 10.1111/aos.14373. [Epub ahead of print] PubMed PMID: 32043815.

2: Nishiguchi KM, Fujita K, Miya F, Katayama S, Nakazawa T. Single AAV-mediated
mutation replacement genome editing in limited number of photoreceptors restores
vision in mice. Nat Commun. 2020 Jan 24;11(1):482. doi:
10.1038/s41467-019-14181-3. PubMed PMID: 31980606; PubMed Central PMCID:
PMC6981188.

3: Kim YW, Kim YJ, Cheong HS, Shiga Y, Hashimoto K, Song YJ, Kim SH, Choi HJ,
Nishiguchi KM, Kawai Y, Nagasaki M, Nakazawa T, Park KH, Kim DM, Jeoung JW.
Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma
in East Asian Cohorts: The GLAU-GENDISK Study. Sci Rep. 2020 Jan 14;10(1):221.
doi: 10.1038/s41598-019-57066-7. PubMed PMID: 31937794; PubMed Central PMCID:
PMC6959350.

4: Nishiguchi KM, Oguchi Y, Nakazawa T. Progression from Classical Oguchi Disease
to Retinitis Pigmentosa after 50 Years. Ophthalmology. 2020 Jan;127(1):51. doi:
10.1016/j.ophtha.2019.09.015. PubMed PMID: 31864474.

5: Fujita K, Nishiguchi KM, Sato K, Nakagawa Y, Nakazawa T. In vivo imaging of
the light response in mouse retinal ganglion cells based on a neuronal
activity-dependent promoter. Biochem Biophys Res Commun. 2020 Jan
8;521(2):471-477. doi: 10.1016/j.bbrc.2019.10.155. Epub 2019 Oct 29. PubMed PMID:
31672273.

6: Nishiguchi KM, Ikeda Y, Fujita K, Kunikata H, Akiho M, Hashimoto K, Hosono K,
Kurata K, Koyanagi Y, Akiyama M, Suzuki T, Kawasaki R, Wada Y, Hotta Y, Sonoda
KH, Murakami A, Nakazawa M, Nakazawa T, Abe T. Phenotypic Features of Oguchi
Disease and Retinitis Pigmentosa in Patients with S-Antigen Mutations: A
Long-Term Follow-up Study. Ophthalmology. 2019 Nov;126(11):1557-1566. doi:
10.1016/j.ophtha.2019.05.027. Epub 2019 Jun 6. PubMed PMID: 31257036.

7: Nikopoulos K, Cisarova K, Quinodoz M, Koskiniemi-Kuendig H, Miyake N,
Farinelli P, Rehman AU, Khan MI, Prunotto A, Akiyama M, Kamatani Y, Terao C, Miya
F, Ikeda Y, Ueno S, Fuse N, Murakami A, Wada Y, Terasaki H, Sonoda KH, Ishibashi
T, Kubo M, Cremers FPM, Kutalik Z, Matsumoto N, Nishiguchi KM, Nakazawa T,
Rivolta C. A frequent variant in the Japanese population determines
quasi-Mendelian inheritance of rare retinal ciliopathy. Nat Commun. 2019 Jun
28;10(1):2884. doi: 10.1038/s41467-019-10746-4. PubMed PMID: 31253780; PubMed
Central PMCID: PMC6599023.

8: Sato R, Kunikata H, Asano T, Aizawa N, Kiyota N, Shiga Y, Nishiguchi KM, Kato
K, Nakazawa T. Quantitative analysis of the macula with optical coherence
tomography angiography in normal Japanese subjects: The Taiwa Study. Sci Rep.
2019 Jun 20;9(1):8875. doi: 10.1038/s41598-019-45336-3. PubMed PMID: 31221998;
PubMed Central PMCID: PMC6586606.

9: Koyanagi Y, Akiyama M, Nishiguchi KM, Momozawa Y, Kamatani Y, Takata S, Inai
C, Iwasaki Y, Kumano M, Murakami Y, Omodaka K, Abe T, Komori S, Gao D, Hirakata
T, Kurata K, Hosono K, Ueno S, Hotta Y, Murakami A, Terasaki H, Wada Y, Nakazawa
T, Ishibashi T, Ikeda Y, Kubo M, Sonoda KH. Genetic characteristics of retinitis
pigmentosa in 1204 Japanese patients. J Med Genet. 2019 Oct;56(10):662-670. doi:
10.1136/jmedgenet-2018-105691. Epub 2019 Jun 17. PubMed PMID: 31213501.

10: Verbakel SK, van Huet RAC, den Hollander AI, Geerlings MJ, Kersten E,
Klevering BJ, Klaver CCW, Plomp AS, Wesseling NL, Bergen AAB, Nikopoulos K,
Rivolta C, Ikeda Y, Sonoda KH, Wada Y, Boon CJF, Nakazawa T, Hoyng CB, Nishiguchi
KM. Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene:
Extending the RP1 Disease Spectrum. Invest Ophthalmol Vis Sci. 2019 Mar
1;60(4):1192-1203. doi: 10.1167/iovs.18-26084. PubMed PMID: 30913292.

11: Nishiguchi KM, Aoki M, Nakazawa T, Abe T. Macular degeneration as a common
cause of visual loss in spinocerebellar ataxia type 1 (SCA1) patients. Ophthalmic
Genet. 2019 Feb;40(1):49-53. doi: 10.1080/13816810.2019.1571614. Epub 2019 Feb 7.
PubMed PMID: 30729852.

12: Tokashiki N, Nishiguchi KM, Fujita K, Sato K, Nakagawa Y, Nakazawa T.
Reliable detection of low visual acuity in mice with pattern visually evoked
potentials. Sci Rep. 2018 Oct 29;8(1):15948. doi: 10.1038/s41598-018-34413-8.
PubMed PMID: 30374137; PubMed Central PMCID: PMC6206061.

13: Sato K, Saigusa D, Saito R, Fujioka A, Nakagawa Y, Nishiguchi KM, Kokubun T,
Motoike IN, Maruyama K, Omodaka K, Shiga Y, Uruno A, Koshiba S, Yamamoto M,
Nakazawa T. Metabolomic changes in the mouse retina after optic nerve injury. Sci
Rep. 2018 Aug 9;8(1):11930. doi: 10.1038/s41598-018-30464-z. PubMed PMID:
30093719; PubMed Central PMCID: PMC6085332.

14: Sato K, Shiga Y, Nakagawa Y, Fujita K, Nishiguchi KM, Tawarayama H, Murayama
N, Maekawa S, Yabana T, Omodaka K, Katayama S, Feng Q, Tsuda S, Nakazawa T. Ecel1
Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve
Damage-Induced RGC Death in the Mouse Retina. Invest Ophthalmol Vis Sci. 2018 Aug
1;59(10):3943-3951. doi: 10.1167/iovs.18-23784. PubMed PMID: 30073365.

15: Nishiguchi KM, Fujita K, Tokashiki N, Komamura H, Takemoto-Kimura S, Okuno H,
Bito H, Nakazawa T. Retained Plasticity and Substantial Recovery of Rod-Mediated
Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy.
Mol Ther. 2018 Oct 3;26(10):2397-2406. doi: 10.1016/j.ymthe.2018.07.012. Epub
2018 Jul 17. PubMed PMID: 30064895; PubMed Central PMCID: PMC6171050.

16: Nishiguchi KM, Fujita K, Inoue T, Nakazawa T. Alternative methods to detect
anti-TRPM1 antibodies. Clin Exp Ophthalmol. 2019 Jan;47(1):148-149. doi:
10.1111/ceo.13365. Epub 2018 Aug 14. PubMed PMID: 30047207.

17: Fukuda M, Omodaka K, Tatewaki Y, Himori N, Matsudaira I, Nishiguchi KM,
Murata T, Taki Y, Nakazawa T. Quantitative MRI evaluation of glaucomatous changes
in the visual pathway. PLoS One. 2018 Jul 9;13(7):e0197027. doi:
10.1371/journal.pone.0197027. eCollection 2018. PubMed PMID: 29985921; PubMed
Central PMCID: PMC6037347.

18: Nishiguchi KM, Fujita K, Inoue T, Nakazawa T. Anti-TRPM1 antibodies in
patients with retinal degeneration. Clin Exp Ophthalmol. 2018
Dec;46(9):1087-1089. doi: 10.1111/ceo.13341. Epub 2018 Jul 1. PubMed PMID:
29927037.

19: Nishiguchi KM, Yokoyama Y, Kunikata H, Abe T, Nakazawa T. Correlation between
aqueous flare and residual visual field area in retinitis pigmentosa. Br J
Ophthalmol. 2019 Apr;103(4):475-480. doi: 10.1136/bjophthalmol-2018-312225. Epub
2018 Jun 1. PubMed PMID: 29858180.

20: Ichinohasama R, Nishiguchi KM, Fujita K, Aizawa N, Inoue T, Sasaki E,
Kunikata H, Nakazawa T. Levels of Anti-Retinal Antibodies in Retinal Detachment
and Proliferative Vitreoretinopathy. Curr Eye Res. 2018 Jun;43(6):804-809. doi:
10.1080/02713683.2018.1451544. Epub 2018 Mar 16. PubMed PMID: 29547015.

21: Shiga Y, Akiyama M, Nishiguchi KM, Sato K, Shimozawa N, Takahashi A, Momozawa
Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M,
Wakai K, Yoshikawa M, Miyake M, Yamashiro K; Japan Glaucoma Society Omics Group
(JGS-OG), Kashiwagi K, Iwata T, Mabuchi F, Takamoto M, Ozaki M, Kawase K, Aihara
M, Araie M, Yamamoto T, Kiuchi Y, Nakamura M, Ikeda Y, Sonoda KH, Ishibashi T,
Nitta K, Iwase A, Shirato S, Oka Y, Satoh M, Sasaki M, Fuse N, Suzuki Y, Cheng
CY, Khor CC, Baskaran M, Perera S, Aung T, Vithana EN, Cooke Bailey JN, Kang JH,
Pasquale LR, Haines JL; NEIGHBORHOOD Consortium, Wiggs JL, Burdon KP, Gharahkhani
P, Hewitt AW, Mackey DA, MacGregor S, Craig JE, Allingham RR, Hauser M, Ashaye A,
Budenz DL, Akafo S, Williams SEI, Kamatani Y, Nakazawa T, Kubo M. Genome-wide
association study identifies seven novel susceptibility loci for primary
open-angle glaucoma. Hum Mol Genet. 2018 Apr 15;27(8):1486-1496. doi:
10.1093/hmg/ddy053. PubMed PMID: 29452408; PubMed Central PMCID: PMC6251544.

22: Ikeda Y, Nishiguchi KM, Miya F, Shimozawa N, Funatsu J, Nakatake S, Fujiwara
K, Tachibana T, Murakami Y, Hisatomi T, Yoshida S, Yasutomi Y, Tsunoda T,
Nakazawa T, Ishibashi T, Sonoda KH. Discovery of a Cynomolgus Monkey Family With
Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):826-830. doi:
10.1167/iovs.17-22958. PubMed PMID: 29411010.

23: Shiga Y, Nishiguchi KM, Kawai Y, Kojima K, Sato K, Fujita K, Takahashi M,
Omodaka K, Araie M, Kashiwagi K, Aihara M, Iwata T, Mabuchi F, Takamoto M, Ozaki
M, Kawase K, Fuse N, Yamamoto M, Yasuda J, Nagasaki M, Nakazawa T; Japan Glaucoma
Society Omics Group (JGS-OG). Genetic analysis of Japanese primary open-angle
glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1,
SIX6 and GAS7. PLoS One. 2017 Dec 20;12(12):e0186678. doi:
10.1371/journal.pone.0186678. eCollection 2017. PubMed PMID: 29261660; PubMed
Central PMCID: PMC5737967.

24: Kampik D, Basche M, Luhmann UFO, Nishiguchi KM, Williams JAE, Greenwood J,
Moss SE, Han H, Azam S, Duran Y, Robbie SJ, Bainbridge JWB, Larkin DF, Smith AJ,
Ali RR. In situ regeneration of retinal pigment epithelium by gene transfer of
E2F2: a potential strategy for treatment of macular degenerations. Gene Ther.
2017 Dec;24(12):810-818. doi: 10.1038/gt.2017.89. Epub 2017 Nov 30. PubMed PMID:
29188796.

25: Kunikata H, Fujita K, Nishiguchi KM, Nakazawa T. Prevalence of anti-retinal
antibodies in epiretinal membranes and macular holes. Clin Exp Ophthalmol. 2018
Jul;46(5):556-558. doi: 10.1111/ceo.13099. Epub 2017 Dec 6. PubMed PMID:
29135070.

26: Mabuchi F, Mabuchi N, Sakurada Y, Yoneyama S, Kashiwagi K, Iijima H, Yamagata
Z, Takamoto M, Aihara M, Iwata T, Kawase K, Shiga Y, Nishiguchi KM, Nakazawa T,
Ozaki M, Araie M; Japan Glaucoma Society Omics Group (JGS-OG). Additive effects
of genetic variants associated with intraocular pressure in primary open-angle
glaucoma. PLoS One. 2017 Aug 23;12(8):e0183709. doi:
10.1371/journal.pone.0183709. eCollection 2017. PubMed PMID: 28832686; PubMed
Central PMCID: PMC5568337.

27: Maekawa S, Sato K, Fujita K, Daigaku R, Tawarayama H, Murayama N, Moritoh S,
Yabana T, Shiga Y, Omodaka K, Maruyama K, Nishiguchi KM, Nakazawa T. The
neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by
suppressing oxidative stress and excessive calpain activation. Sci Rep. 2017 Jul
31;7(1):6885. doi: 10.1038/s41598-017-06969-4. PubMed PMID: 28761134; PubMed
Central PMCID: PMC5537259.

28: Fujita K, Nishiguchi KM, Shiga Y, Nakazawa T. Spatially and Temporally
Regulated NRF2 Gene Therapy Using Mcp-1 Promoter in Retinal Ganglion Cell Injury.
Mol Ther Methods Clin Dev. 2017 Apr 19;5:130-141. doi:
10.1016/j.omtm.2017.04.003. eCollection 2017 Jun 16. PubMed PMID: 28480312;
PubMed Central PMCID: PMC5415330.

29: Himori N, Kunikata H, Inoue M, Takeshita T, Nishiguchi KM, Nakazawa T. Optic
nerve head microcirculation in autosomal dominant optic atrophy and
normal-tension glaucoma. Acta Ophthalmol. 2017 Dec;95(8):e799-e800. doi:
10.1111/aos.13353. Epub 2017 Jan 30. PubMed PMID: 28134500.

30: Yamamoto K, Sato K, Yukita M, Yasuda M, Omodaka K, Ryu M, Fujita K,
Nishiguchi KM, Machida S, Nakazawa T. The neuroprotective effect of latanoprost
acts via klotho-mediated suppression of calpain activation after optic nerve
transection. J Neurochem. 2017 Feb;140(3):495-508. doi: 10.1111/jnc.13902. Epub
2016 Dec 27. PubMed PMID: 27859240; PubMed Central PMCID: PMC5299490.

31: Nishiguchi KM, Yokoyama Y, Fujii Y, Fujita K, Tomiyama Y, Kawasaki R,
Furukawa T, Ono F, Shimozawa N, Togo M, Suzuki M, Nakazawa T. Analysis of Macular
Drusen and Blood Test Results in 945 Macaca fascicularis. PLoS One. 2016 Oct
24;11(10):e0164899. doi: 10.1371/journal.pone.0164899. eCollection 2016. PubMed
PMID: 27776188; PubMed Central PMCID: PMC5077098.

32: Inoue M, Himori N, Kunikata H, Takeshita T, Aizawa N, Shiga Y, Omodaka K,
Nishiguchi KM, Takahashi H, Nakazawa T. The reduction of temporal optic nerve
head microcirculation in autosomal dominant optic atrophy. Acta Ophthalmol. 2016
Nov;94(7):e580-e585. doi: 10.1111/aos.12999. Epub 2016 Mar 3. PubMed PMID:
26936288.

33: Yasuda M, Tanaka Y, Omodaka K, Nishiguchi KM, Nakamura O, Tsuda S, Nakazawa
T. Transcriptome profiling of the rat retina after optic nerve transection. Sci
Rep. 2016 Jun 29;6:28736. doi: 10.1038/srep28736. PubMed PMID: 27353354; PubMed
Central PMCID: PMC4926057.

34: Yukita M, Omodaka K, Machida S, Yasuda M, Sato K, Maruyama K, Nishiguchi KM,
Nakazawa T. Brimonidine Enhances the Electrophysiological Response of Retinal
Ganglion Cells through the Trk-MAPK/ERK and PI3K Pathways in Axotomized Eyes.
Curr Eye Res. 2017 Jan;42(1):125-133. doi: 10.3109/02713683.2016.1153112. Epub
2016 Jun 17. PubMed PMID: 27314704.

35: Tomiyama Y, Fujita K, Nishiguchi KM, Tokashiki N, Daigaku R, Tabata K, Sugano
E, Tomita H, Nakazawa T. Measurement of Electroretinograms and Visually Evoked
Potentials in Awake Moving Mice. PLoS One. 2016 Jun 3;11(6):e0156927. doi:
10.1371/journal.pone.0156927. eCollection 2016. PubMed PMID: 27257864; PubMed
Central PMCID: PMC4892628.

36: Hashimoto K, Kunikata H, Yasuda M, Ito A, Aizawa N, Sawada S, Kondo K, Satake
C, Takano Y, Nishiguchi KM, Katagiri H, Nakazawa T. The relationship between
advanced glycation end products and ocular circulation in type 2 diabetes. J
Diabetes Complications. 2016 Sep-Oct;30(7):1371-7. doi:
10.1016/j.jdiacomp.2016.04.024. Epub 2016 May 4. PubMed PMID: 27209548.

37: Corton M, Nishiguchi KM, Avila-Fernández A, Nikopoulos K, Riveiro-Alvarez R,
Tatu SD, Ayuso C, Rivolta C. Correction: Exome Sequencing of Index Patients with
Retinal Dystrophies as a Tool for Molecular Diagnosis. PLoS One. 2016 Mar
31;11(3):e0153121. doi: 10.1371/journal.pone.0153121. eCollection 2016. PubMed
PMID: 27031522; PubMed Central PMCID: PMC4816403.

38: Wang Z, Iida A, Miyake N, Nishiguchi KM, Fujita K, Nakazawa T, Alswaid A,
Albalwi MA, Kim OH, Cho TJ, Lim GY, Isidor B, David A, Rustad CF, Merckoll E,
Westvik J, Stattin EL, Grigelioniene G, Kou I, Nakajima M, Ohashi H, Smithson S,
Matsumoto N, Nishimura G, Ikegawa S. Axial Spondylometaphyseal Dysplasia Is
Caused by C21orf2 Mutations. PLoS One. 2016 Mar 14;11(3):e0150555. doi:
10.1371/journal.pone.0150555. eCollection 2016. PubMed PMID: 26974433; PubMed
Central PMCID: PMC4790905.

39: Sato K, Nishiguchi KM, Maruyama K, Moritoh S, Fujita K, Ikuta Y, Kasai H,
Nakazawa T. Topical ocular dexamethasone decreases intraocular pressure and body
weight in rats. J Negat Results Biomed. 2016 Mar 12;15:5. doi:
10.1186/s12952-016-0048-x. PubMed PMID: 26971048; PubMed Central PMCID:
PMC4789283.

40: Fujita K, Nishiguchi KM, Yokoyama Y, Tomiyama Y, Tsuda S, Yasuda M, Maekawa
S, Nakazawa T. In vivo cellular imaging of various stress/response pathways using
AAV following axonal injury in mice. Sci Rep. 2015 Dec 16;5:18141. doi:
10.1038/srep18141. PubMed PMID: 26670005; PubMed Central PMCID: PMC4680972.

41: Saqib MA, Nikopoulos K, Ullah E, Sher Khan F, Iqbal J, Bibi R, Jarral A,
Sajid S, Nishiguchi KM, Venturini G, Ansar M, Rivolta C. Homozygosity mapping
reveals novel and known mutations in Pakistani families with inherited retinal
dystrophies. Sci Rep. 2015 May 6;5:9965. doi: 10.1038/srep09965. PubMed PMID:
25943428; PubMed Central PMCID: PMC4421863.

42: Nishiguchi KM, Carvalho LS, Rizzi M, Powell K, Holthaus SM, Azam SA, Duran Y,
Ribeiro J, Luhmann UF, Bainbridge JW, Smith AJ, Ali RR. Gene therapy restores
vision in rd1 mice after removal of a confounding mutation in Gpr179. Nat Commun.
2015 Jan 23;6:6006. doi: 10.1038/ncomms7006. PubMed PMID: 25613321; PubMed
Central PMCID: PMC4354202.

43: Aboshiha J, Dubis AM, van der Spuy J, Nishiguchi KM, Cheeseman EW, Ayuso C,
Ehrenberg M, Simonelli F, Bainbridge JW, Michaelides M. Preserved outer retina in
AIPL1 Leber's congenital amaurosis: implications for gene therapy. Ophthalmology.
2015 Apr;122(4):862-4. doi: 10.1016/j.ophtha.2014.11.019. Epub 2015 Jan 14.
PubMed PMID: 25596619.

44: Yukita M, Machida S, Nishiguchi KM, Tsuda S, Yokoyama Y, Yasuda M, Maruyama
K, Nakazawa T. Molecular, anatomical and functional changes in the retinal
ganglion cells after optic nerve crush in mice. Doc Ophthalmol. 2015
Apr;130(2):149-56. doi: 10.1007/s10633-014-9478-2. Epub 2015 Jan 6. PubMed PMID:
25560383.

45: Yasuda M, Tanaka Y, Nishiguchi KM, Ryu M, Tsuda S, Maruyama K, Nakazawa T.
Retinal transcriptome profiling at transcription start sites: a cap analysis of
gene expression early after axonal injury. BMC Genomics. 2014 Nov 18;15:982. doi:
10.1186/1471-2164-15-982. PubMed PMID: 25407019; PubMed Central PMCID:
PMC4246558.

46: Omodaka K, Nishiguchi KM, Yasuda M, Tanaka Y, Sato K, Nakamura O, Maruyama K,
Nakazawa T. Neuroprotective effect against axonal damage-induced retinal ganglion
cell death in apolipoprotein E-deficient mice through the suppression of kainate
receptor signaling. Brain Res. 2014 Oct 24;1586:203-12. doi:
10.1016/j.brainres.2014.08.053. Epub 2014 Aug 24. PubMed PMID: 25160129.

47: Yokoyama Y, Maruyama K, Yamamoto K, Omodaka K, Yasuda M, Himori N, Ryu M,
Nishiguchi KM, Nakazawa T. The role of calpain in an in vivo model of oxidative
stress-induced retinal ganglion cell damage. Biochem Biophys Res Commun. 2014 Sep
5;451(4):510-5. doi: 10.1016/j.bbrc.2014.08.009. Epub 2014 Aug 8. PubMed PMID:
25111816.

48: Tanaka Y, Tsuda S, Kunikata H, Sato J, Kokubun T, Yasuda M, Nishiguchi KM,
Inada T, Nakazawa T. Profiles of extracellular miRNAs in the aqueous humor of
glaucoma patients assessed with a microarray system. Sci Rep. 2014 May 28;4:5089.
doi: 10.1038/srep05089. PubMed PMID: 24867291; PubMed Central PMCID: PMC4035584.

49: Nishiguchi KM, Avila-Fernandez A, van Huet RA, Corton M, Pérez-Carro R,
Martín-Garrido E, López-Molina MI, Blanco-Kelly F, Hoefsloot LH, van Zelst-Stams
WA, García-Ruiz PJ, Del Val J, Di Gioia SA, Klevering BJ, van de Warrenburg BP,
Vazquez C, Cremers FP, García-Sandoval B, Hoyng CB, Collin RW, Rivolta C, Ayuso
C. Exome sequencing extends the phenotypic spectrum for ABHD12 mutations: from
syndromic to nonsyndromic retinal degeneration. Ophthalmology. 2014
Aug;121(8):1620-7. doi: 10.1016/j.ophtha.2014.02.008. Epub 2014 Mar 31. Erratum
in: Ophthalmology. 2017 Feb;124(2):273-274. PubMed PMID: 24697911.

50: Ueno S, Nishiguchi KM, Tanioka H, Enomoto A, Yamanouchi T, Kondo M, Yasuma
TR, Yasuda S, Kuno N, Takahashi M, Terasaki H. Degeneration of retinal on bipolar
cells induced by serum including autoantibody against TRPM1 in mouse model of
paraneoplastic retinopathy. PLoS One. 2013 Nov 25;8(11):e81507. doi:
10.1371/journal.pone.0081507. eCollection 2013. PubMed PMID: 24282602; PubMed
Central PMCID: PMC3840061.

51: Nishiguchi KM, Tearle RG, Liu YP, Oh EC, Miyake N, Benaglio P, Harper S,
Koskiniemi-Kuendig H, Venturini G, Sharon D, Koenekoop RK, Nakamura M, Kondo M,
Ueno S, Yasuma TR, Beckmann JS, Ikegawa S, Matsumoto N, Terasaki H, Berson EL,
Katsanis N, Rivolta C. Whole genome sequencing in patients with retinitis
pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease
gene. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16139-44. doi:
10.1073/pnas.1308243110. Epub 2013 Sep 16. PubMed PMID: 24043777; PubMed Central
PMCID: PMC3791719.

52: Corton M, Nishiguchi KM, Avila-Fernández A, Nikopoulos K, Riveiro-Alvarez R,
Tatu SD, Ayuso C, Rivolta C. Exome sequencing of index patients with retinal
dystrophies as a tool for molecular diagnosis. PLoS One. 2013 Jun 14;8(6):e65574.
doi: 10.1371/journal.pone.0065574. Print 2013. Erratum in: PLoS One.
2016;11(3):e0153121. PubMed PMID: 23940504; PubMed Central PMCID: PMC3683009.

53: Nishiguchi KM, Ushida H, Tomida D, Kachi S, Kondo M, Terasaki H.
Age-dependent alteration of intraocular soluble heparan sulfate levels and its
implications for proliferative diabetic retinopathy. Mol Vis. 2013 May
29;19:1125-31. Print 2013. PubMed PMID: 23734081; PubMed Central PMCID:
PMC3669540.

54: Nishiguchi KM, Ito Y, Terasaki H. Bilateral central retinal artery occlusion
and vein occlusion complicated by severe choroidopathy in systemic lupus
erythematosus. Lupus. 2013 Jun;22(7):733-5. doi: 10.1177/0961203313490435. Epub
2013 May 16. PubMed PMID: 23681406.

55: Avila-Fernandez A, Corton M, Nishiguchi KM, Muñoz-Sanz N, Benavides-Mori B,
Blanco-Kelly F, Riveiro-Alvarez R, Garcia-Sandoval B, Rivolta C, Ayuso C.
Identification of an RP1 prevalent founder mutation and related phenotype in
Spanish patients with early-onset autosomal recessive retinitis. Ophthalmology.
2012 Dec;119(12):2616-21. doi: 10.1016/j.ophtha.2012.06.033. Epub 2012 Aug 20.
PubMed PMID: 22917891.

56: Nishiguchi KM, Rivolta C. Genes associated with retinitis pigmentosa and
allied diseases are frequently mutated in the general population. PLoS One.
2012;7(7):e41902. doi: 10.1371/journal.pone.0041902. Epub 2012 Jul 27. PubMed
PMID: 22848652; PubMed Central PMCID: PMC3407128.

57: Nishiguchi KM, Yasuma TR, Tomida D, Nakamura M, Ishikawa K, Kikuchi M, Ohmi
Y, Niwa T, Hamajima N, Furukawa K, Terasaki H. C9-R95X polymorphism in patients
with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci.
2012 Jan 31;53(1):508-12. doi: 10.1167/iovs.11-8425. PubMed PMID: 22190594.

58: Tomida D, Nishiguchi KM, Kataoka K, Yasuma TR, Iwata E, Uetani R, Kachi S,
Terasaki H. Suppression of choroidal neovascularization and quantitative and
qualitative inhibition of VEGF and CCL2 by heparin. Invest Ophthalmol Vis Sci.
2011 May 16;52(6):3193-9. doi: 10.1167/iovs.10-6737. PubMed PMID: 21296829.

59: Yasuma TR, Nakamura M, Nishiguchi KM, Kikuchi M, Kaneko H, Niwa T, Hamajima
N, Terasaki H. Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants
in subjects without age-related macular degeneration. Mol Vis. 2010 Dec
31;16:2923-30. PubMed PMID: 21203342; PubMed Central PMCID: PMC3013066.

60: Kataoka K, Nishiguchi KM, Kaneko H, van Rooijen N, Kachi S, Terasaki H. The
roles of vitreal macrophages and circulating leukocytes in retinal
neovascularization. Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1431-8. doi:
10.1167/iovs.10-5798. PubMed PMID: 21051720.

61: Nishiguchi KM, Kataoka K, Kachi S, Komeima K, Terasaki H. Regulation of
pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by
soluble heparan sulfate. PLoS One. 2010 Oct 20;5(10):e13493. doi:
10.1371/journal.pone.0013493. PubMed PMID: 20975989; PubMed Central PMCID:
PMC2958111.

62: Nakamura M, Sanuki R, Yasuma TR, Onishi A, Nishiguchi KM, Koike C, Kadowaki
M, Kondo M, Miyake Y, Furukawa T. TRPM1 mutations are associated with the
complete form of congenital stationary night blindness. Mol Vis. 2010 Mar
12;16:425-37. PubMed PMID: 20300565; PubMed Central PMCID: PMC2838739.

63: Nishiguchi KM, Kaneko H, Nakamura M, Kachi S, Terasaki H. Generation of
immature retinal neurons from proliferating cells in the pars plana after retinal
histogenesis in mice with retinal degeneration. Mol Vis. 2009;15:187-99. Epub
2009 Jan 23. PubMed PMID: 19169413; PubMed Central PMCID: PMC2629738.

64: Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H. Characteristics of
bone marrow-derived microglia in the normal and injured retina. Invest Ophthalmol
Vis Sci. 2008 Sep;49(9):4162-8. doi: 10.1167/iovs.08-1738. Epub 2008 May 16.
PubMed PMID: 18487364.

65: Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H. Retardation of
photoreceptor degeneration in the detached retina of rd1 mouse. Invest Ophthalmol
Vis Sci. 2008 Feb;49(2):781-7. doi: 10.1167/iovs.07-0715. PubMed PMID: 18235028.

66: Nishiguchi KM, Kaneko H, Nakamura M, Kachi S, Terasaki H. Identification of
photoreceptor precursors in the pars plana during ocular development and after
retinal injury. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):422-8. doi:
10.1167/iovs.07-1008. PubMed PMID: 18172121.

67: Nishiguchi KM, Nakamura M, Kaneko H, Kachi S, Terasaki H. The role of VEGF
and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal
degeneration. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4315-20. PubMed PMID:
17724222.

68: Kanda A, Friedman JS, Nishiguchi KM, Swaroop A. Retinopathy mutations in the
bZIP protein NRL alter phosphorylation and transcriptional activity. Hum Mutat.
2007 Jun;28(6):589-98. PubMed PMID: 17335001.

69: Lin J, Nishiguchi KM, Nakamura M, Dryja TP, Berson EL, Miyake Y. Recessive
mutations in the CYP4V2 gene in East Asian and Middle Eastern patients with
Bietti crystalline corneoretinal dystrophy. J Med Genet. 2005 Jun;42(6):e38.
PubMed PMID: 15937078; PubMed Central PMCID: PMC1736086.

70: Nishiguchi KM, Sandberg MA, Gorji N, Berson EL, Dryja TP. Cone cGMP-gated
channel mutations and clinical findings in patients with achromatopsia, macular
degeneration, and other hereditary cone diseases. Hum Mutat. 2005
Mar;25(3):248-58. PubMed PMID: 15712225.

71: Nishiguchi KM, Friedman JS, Sandberg MA, Swaroop A, Berson EL, Dryja TP.
Recessive NRL mutations in patients with clumped pigmentary retinal degeneration
and relative preservation of blue cone function. Proc Natl Acad Sci U S A. 2004
Dec 21;101(51):17819-24. Epub 2004 Dec 9. PubMed PMID: 15591106; PubMed Central
PMCID: PMC535407.

72: Nishiguchi KM, Sokal I, Yang L, Roychowdhury N, Palczewski K, Berson EL,
Dryja TP, Baehr W. A novel mutation (I143NT) in guanylate cyclase-activating
protein 1 (GCAP1) associated with autosomal dominant cone degeneration. Invest
Ophthalmol Vis Sci. 2004 Nov;45(11):3863-70. PubMed PMID: 15505030; PubMed
Central PMCID: PMC1475955.

73: Nishiguchi KM, Berson EL, Dryja TP. Mutation screening of the phosducin gene
PDC in patients with retinitis pigmentosa and allied diseases. Mol Vis. 2004 Jan
26;10:62-4. PubMed PMID: 14758335.

74: Fishman GA, Roberts MF, Derlacki DJ, Grimsby JL, Yamamoto H, Sharon D,
Nishiguchi KM, Dryja TP. Novel mutations in the cellular retinaldehyde-binding
protein gene (RLBP1) associated with retinitis punctata albescens: evidence of
interfamilial genetic heterogeneity and fundus changes in heterozygotes. Arch
Ophthalmol. 2004 Jan;122(1):70-5. PubMed PMID: 14718298.

75: Nishiguchi KM, Sandberg MA, Kooijman AC, Martemyanov KA, Pott JW, Hagstrom
SA, Arshavsky VY, Berson EL, Dryja TP. Defects in RGS9 or its anchor protein R9AP
in patients with slow photoreceptor deactivation. Nature. 2004 Jan
1;427(6969):75-8. PubMed PMID: 14702087.