Biology Molecular biology

News

16 Feb 2024
Researchers at Kanazawa University report in Journal of Cell Science on a novel role of the small Ca2+-binding protein S100A11 in focal adhesion disassembly.
Compared with untreated cancer, the TRED-I system significantly reduced cancer size in mice models. (Xin Sun, et al. Proceedings of the National Academy of Sciences. January 29, 2024)
29 Jan 2024
A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.
Depiction of europium complexes changing structure upon interacting with a tumor cell. (Mengfei Wang, et al. Scientific Reports. January 22, 2024)
22 Jan 2024
A water-soluble, luminescent europium complex enables evaluation of malignancy grade in model glioma tumor cells.
20 Dec 2023
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes. The findings provide insights into the mechanism behind the generation of cell-membrane action potentials.
4.5SH RNA (green) is located in the nuclear speckles (Srsf1, magenta)—structures in the cell nucleus associated with gene expression—in embryonic stem cells, where it plays an essential role in RNA processing. (Rei Yoshimoto, et al. Molecular Cell. December 13, 2023)
13 Dec 2023
A previously mysterious small RNA molecule in mice is found to play a crucial role in gene expression, and may be the first identified member of a new class of regulatory RNAs.
30 Nov 2023
An international team of researchers led by Osaka Metropolitan University has elucidated the process by which the major flavonoids naringenin, apigenin, and genistein are metabolized in the body. These findings are fundamental in elucidating the correlation between the metabolism of flavonoids in the body and their potential health benefits.
A C57BL/6 mouse used in the study (Photo: Haruka Wada)
14 Nov 2023
Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.
09 Nov 2023
New shrimp species in ancient hot spring, Super sprouts, How "warm-ups" work, New antiviral candidate, Solving voltage decay and from our blog: A sustainable future shines in TIE 2023. Read all in the latest Editor's Choice.
20 Oct 2023
A research team from Osaka Metropolitan University has found that polysulfides are abundant in broccoli sprouts. They found that the amount of polysulfides increased dramatically during growth, by an approximately 20-fold in seeds by the fifth day of germination. Furthermore, a comprehensive analysis of the polysulfides detected a number of polysulfide candidates whose structures have not yet been determined. The identification of these unknown polysulfides and detailed analysis of their pharmacological activities are expected to enable the development of new preventive and therapeutic strategies and medicines for cancer, neurodegenerative diseases, stroke, inflammation, and other diseases.
Asia Research News Editors Choice
05 Oct 2023
Hunting for supermassive black holes, Coastal survival at risk, Calcium and dead cell clean-up, Two naps are better than one & Pineapple leaf prosthetics. Read all in the latest Editor's Choice.
29 Sep 2023
The authors discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells.
29 Sep 2023
The authors identified a structure in the circadian mRNA Period2 that affects the sleep-wake cycle. The results indicate how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns.
IMAGE
14 Sep 2023
Scientists have found that extracellular calcium mediates the activation of a membrane protein that waves the flag signalling cell death
Illustration depicting the effects of anti-estrogenic therapies on cancers that are not estrogen-sensitive (Illustration provided by Nabeel Kajihara)
21 Aug 2023
Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.
28 Jul 2023
Scientists have isolated potent neutralising antibodies from a COVID-19 vaccinated SARS survivor that exhibited remarkable breadth against known sarbecoviruses. The antibodies targeted a conserved region of the spike protein and blocked receptor binding and viral fusion. These findings could guide the development of broadly active therapeutics against current and future coronaviruses.
11 Jul 2023
A research team has discovered an astounding array of unexplored protein folds. This research will expand our understanding of the depth of the protein universe and the possibilities for de novo design of functional proteins.
Microbial cultures used in the study to investigate the biosynthesis of actinopyradizone (Photo: Kenichi Matsuda).
11 Jul 2023
The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.
26 Jun 2023
What scientists learned about the rare antibodies targeting SARS-CoV-2’s Achilles’ heel could help fine-tune our COVID-19 vaccine strategy for longer-lasting immunity.
26 May 2023
A research team, led by researchers from Osaka University, performed genetic screening of fission yeast lacking DNA repair gene Rad51 to identify genes that play a role in gross chromosomal rearrangement (GCR), a type of mutation that occurs at the centromere. Cells lacking Srr1 or Skb1 exhibited reduced GCR, indicating that these genes are important to the occurrence of GCR. These findings advance our understanding of the mechanisms underlying centromeric GCR.
17 May 2023
A research group led by Osaka University has found that plant cells may be able to detect mechanical forces to determine their own position within the leaf—whether they are on the surface or in the inner tissues—and therefore differentiate into appropriate cell types after damage. These findings reveal how plants regenerate the correct type of tissues when damaged, and may improve our understanding of the mechanisms underlying the high regeneration potential of plants.
Arbuscular mycorrhizal (AM) fungi in the Glomeromycotina colonize plant roots (left, micrograph) and deliver water and nutrients from soil (right). (Tatsuhiro Ezawa).
11 May 2023
A new group of mitochondrial viruses confined to the arbuscular mycorrhizal fungi Glomeromycotina may represent an ancestral lineage of mitoviruses.
Damage to the liver induced by acetaminophen (dotted blue outlines) is almost completely mitigated by CoQ10-MITO-Porter (right), compared to the effect of phosphate buffered saline (left) and direct administration of CoQ10(center). (Mitsue Hibino, et al. Scientific Reports. May 10, 2023).
10 May 2023
A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.
Asia Research News monthly Editors Choice
10 Apr 2023
AI finds the first stars ✨were not alone, Auto-switch for large electronic devices, A metabolite against autoimmune diseases, & Converting fruit waste 🍊🍉into solar stills. Plus in our blog: A career worth doing, a life worth living. Read all in the latest Editor's Choice.
28 Mar 2023
A group including Osaka Metropolitan University researchers discovered that the rhodopsin—a protein in the eye that detects light—of whale sharks has changed to efficiently detect blue light, which penetrates deep-sea water easily. The amino acid substitutions–one of which is counterintuitively associated with congenital stationary night blindness in humans—aid in detecting the low levels of light in the deep-sea. Although these changes make the whale shark rhodopsin less thermally stable the deep-sea temperature, allows their rhodopsin to keep working. This suggests that the unique adaptation evolved to function in the low-light low-temperature environment where whale sharks live.
In mice models with adoptive transfer experimental autoimmune encephalomyelitis, treatment with itaconate (right) greatly ameliorates the effects of the disease, compared to untreated mice (Kuniyuki Aso, et al. Nature Communications. February 27, 2023).
15 Mar 2023
Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.
The RNP-ssODN is designed to ensure the CRISPR-Cas9 molecule is encapsulated by the LNP. Once inside the cells, the ssODN dissociates and CRISPR-Cas9 can carry out its effect. (Haruno Onuma, Yusuke Sato, Hideyoshi Harashima. Journal of Controlled Release. February 10, 2023).
02 Mar 2023
Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.
Collecting samples at a wastewater treatment plant for the study (Photo provided by Masaaki Kitajima).
21 Feb 2023
Sifting through sewage for SARS-CoV-2 genetic material could help authorities tailor infection control policies.
12 Feb 2023
In hepatic steatosis, hepatocytes "die," resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis predominantly causes necroptosis leading to cell rupture. This induces strong inflammation and new cell death, producing further liver damage. We reveal the transcription factor ATF3 to be involved in this process. Our results are expected to contribute to therapeutic method development.
The fluorescent blinking of cyanine dye (Alexa Fluor 647, pink star) bound to RNA changes depending on the structure of the RNA. When the RNA is folded like a hairpin, the fluorescent blinking is fast, and when the RNA switches to a G-quadruplex, the blinking is slow (Akira Kitamura).
02 Feb 2023
A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.
Asia Research News: Editor's choice
20 Jan 2023
Overeating mechanism: why "eating just one chip"🍟 is impossible, Measuring hidden energy of gamma-ray bursts, Marine species that can adapt to ocean acidification & A rough start can lead to a strong bond, Read all in our first Editor's Choice of 2023. Plus our interview on what dengue vaccine approval in EU💉means for global dengue protection.

Events

01 Mar 2022 to 02 Mar 2022
The Nano Life Science Institute (WPI-NanoLSI) at Kanazawa University will hold their 5th NanoLSI Symposium 1-2 March 2022, online.
30 Jul 2021
The International Union of Biochemistry and Molecular Biology (IUBMB), the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) and the College of Biochemists of Sri Lanka (CBSL), will conduct the 1st Virtual Education Symposium themed “The ‘New Normal’ Biochemistry and Molecular Biology Education”, on the 30thof July 2021.

Researchers

Dr Sarkar is a senior research fellow at the Murdoch Children's Research Institute in Melbourne, Australia. She is actively engaged in collaborating with academic and industry stakeholders and leads multiple projects for the development of novel therapeutics/vaccines to tackle antimicrobial resistance.
Mags Crumlish
Dr. Crumlish has researched aquatic microbial diseases, specifically ones that have economic impact in global aquaculture, and potential solutions to such infectious diseases. Her current project seeks to develop vaccines against antimicrobial resistance in aquaculture.
Dr. Stefan Oehlers
Dr. Oehlers leads the Bacterial Pathogenesis Laboratory at A*STAR ID Labs, where he and his colleagues focus on identifying molecular bases of mycobacterial disease and, thus, deploy therapies that address antibiotic resistance in mycobacterial infections.
Professor Yue Wang
Dr. Yue Wang is senior principal investigator at the Antifungal Resistance Laboratory of A*STAR ID Labs, where his body of work focuses on virulence mechanisms of the fungal human pathogen Candida albicans.
Jian Yan
Dr. Yan is an assistant professor at the Department of Biomedical Sciences, City University of Hong Kong (CityU). His current research focuses on developing genomic tools to dissect lncRNA function and mechanism in diseases and to identify genetic variations that contribute to disease pathogenesis.
Robert Mitchell of UNIST
Dr. Mitchell is a professor at the Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST). His primary research interest is the study of bacterial strains that attack and prey on other bacteria, including antimicrobial-resistant pathogens.
Dr. Soojin Jang
Dr. Soojin Jang heads the Antibacterial Resistance Research Laboratory at Institut Pasteur Korea, where her team focuses on discovering new antibacterial agents for “superbugs” or bacteria resistant to most antibiotics.
Dr. Tengku Haziyamin Tengku Abdul Hamid
Dr. Tengku Haziyamin Tengku Abdul Hamid's recent discovery of a novel strain has enabled a new patent to be drafted and was awarded gold medal in Malaysian Technology Expo 2021 for his new probiotic prototype called ProAquaVcare.
Nimanthi Jayathilaka is a professor at the Department of Chemistry, University of Kelaniya, Sri Lanka.
Professor Ahmed Al-Haddad, M.Sc., Ph.D. (Germany) is currently Professor of Microbiology and Medical Microbiology at College of Medicine and Health Sciences, Hadhramout University-Yemen. He is the Founding-Dean of the first Faculty of Nursing in Yemen. He has over fifteen years of research and teaching experience in various domains of life sciences. Al-Haddad has published many peer reviewed articles and conference papers in the areas of molecular biology, microbiology and antibiotics in National and International journals. He is reviewer in different national and international Scientific Journals such as Annals of Clinical Microbiology and Antimicrobials, Journal of Microbiology and Antimicrobials, Sultan Qaboos University Medical Journal, British Biotechnology Journal. He is a member of various national and international scientific organizations.
Viteroretinal surgeon working on developing treatments for retinal dystrophies and many other retinal diseases.

Giants in history

Maharani Chakravorty (1937 – 2015) was one of India’s earliest molecular biologists whose research paved the way for advances in the treatment of bacterial and viral infections.
Motoo Kimura (13 November 1924 – 13 November 1994) was a Japanese theoretical population geneticist who is best remembered for developing the neutral theory of molecular evolution.
Gopalasamudram Narayanan Ramachandran (8 October 1922 – 7 April 2001) is best known for developing the Ramachandran plot to understand the structure of short chains of amino acids, known as peptides.
Syed Qasim Mehdi (13 February 1941 – 28 September 2016) was a Pakistani molecular biologist who was a founding member of the Human Genome Diversity Project (HGDP), which assessed human diversity by studying human migration, mutation rates, relationships between different populations, genes involved in height and selective pressure.