Biology Molecular biology

News

Chie Nakajima, DVM, Ph.D. and Kyoko Hayashida, DVM, Ph.D.
25 Feb 2021
This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).
When quiescent neural stem cells in the fruit fly larval brain are activated, they can generate new neurons. In the image, the nucleus of quiescent neural stem cells is labelled by a marker of neural stem cells named Deadpan in magenta, and the cell outline is marked in green.
11 Feb 2021
A brain enzyme activates dormant neural stem cells, revealing how defects in its gene could lead to neurodevelopmental disorders.
09 Feb 2021
Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in vivo is difficult, so the molecular mechanisms underlying the stemness of gastric tissue stem cells have remained a mystery. Here, by using organoids that mimic tissue structure and function in vivo and GeCKO screening to inactivate arbitrary genes, Alk, Bclaf3 and Prkra have been identified as genes regulating stemness.
Actin-dependent nuclear displacement observed in several mitotic mutants in fission yeast.
04 Feb 2021
Cells replicate their genetic material and divide into two identical clones to perpetuate life. Some cells pause in the process with a single, undivided nucleus. When the cell resumes division after such a pause, the nucleus can become caught in the fissure, splitting violently, and killing both cells. But that is not always the case. Researchers from Hiroshima University in Japan are starting to understand how active nuclear displacement rescues cell death.
The Asian blue tick with its eggs
28 Jan 2021
A tick saliva study reveals immune responses that could lead to better protection for cattle.
28 Dec 2020
Investigations of a cellular protein have uncovered a possible link with schizophrenia.
iCeMS Ueda ABCB1
28 Dec 2020
iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells.
23 Dec 2020
A transporter protein that regulates cell membrane cholesterol likely played an important role in vertebrate evolution, according to a review published by iCeMS researchers in the journal FEBS Letters.
19 Nov 2020
A repetitive DNA sequence that causes health risks when it malfunctions can now be watched inside living cells using a synthetic tool
06 Oct 2020
Researchers at Kanazawa University report in Nature Communications the mechanism making some lung-cancer patients resistant to the drug osimertinib. In addition, they suggest a combined drug treatment resolving osimertinib resistance in the case of cancer cells expressing low amounts of AXL, a protein belonging to the class of receptor tyrosine kinases.
28 Sep 2020
Testing self-collected saliva samples could offer an easy and effective mass testing approach for detecting asymptomatic COVID-19.
15 Sep 2020
A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.
Macrophage Activation Syndrome in COVID-19
08 Sep 2020
Scientists review macrophage activation syndrome — a feature of the cytokine storm that kills patients with severe cases of COVID-19, as well as possible treatments.
07 Sep 2020
Researchers at Kanazawa University report in Nature Communications the discovery that in the developing fly brain, neurons stemming from the same parent cell experience repulsion. This lineage-dependent repulsion is regulated by a protein known as Dscam1.
26 Aug 2020
A group of scientists have detected genetic material from SARS-CoV-2 in untreated wastewater samples collected in April 2020 from two wastewater treatment plants in Louisiana, USA.
Hypothesis for mechanism of action of IL-34 in TNBC
21 Aug 2020
Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.
Methods used to recover MHV in this study
12 Aug 2020
A group of researchers have demonstrated that, from seven methods commonly used to test for viruses in untreated wastewater, an adsorption-extraction technique can most efficiently detect SARS-CoV-2. This gives us another tool to detect the presence and spread of the COVID-19 pandemic
18 Jun 2020
Scientists are looking for ways to make millions of molecule-sized robots swarm together so they can perform multiple tasks simultaneously.
18 May 2020
Research at Kanazawa University, Theragen Etex Bio Institute and Seoul National University as reported in Nature Communications points towards pathways for the metastasis and malignant transitions that result from changes in the protein p53. The results suggest that the cooperative development of mutations in the proteins helps tumours spread and metastasis.
12 May 2020
In a recent study published in Molecular Cell, researchers at Kanazawa University report the role of cellular structures called PML bodies in regulating gene function
12 May 2020
Researchers from Daegu Gyeongbuk Institute of Science and Technology(DGIST) have developed an innovative method that allows them to visualize up to tens of different proteins simultaneously in the same cell. This technology could help scientists elucidate the complex protein interactions involved in degenerative diseases such as Alzheimer’s, deepening our understanding of their mechanisms and allowing for early detection and treatment.
07 Feb 2020
A calf was born from an embryo lacking cells which form a large part of the placenta, providing new insight into the regenerative capacity of mammalian embryos.
07 Feb 2020
Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous system. The approach lies in combining two cancer drugs, with one compensating for a resistance side effect of the other.
14 Jan 2020
A Chinese medicine research team at Hong Kong Baptist University (HKBU) has identified a unique polysaccharide marker from the caterpillar part of Cordyceps sinensis, and successfully applied it to the qualitative and quantitative authentication of this valuable Chinese herbal medicine. This novel, low-cost method can authenticate Cordyceps sinensis in an hour.
13 Jan 2020
A hyperactive gene response to Japanese encephalitis virus infection ultimately leads to brain inflammation.
08 Jan 2020
New findings could lead the way towards treatments for intellectual disability in Down syndrome.
09 Dec 2019
A chemical cage suppresses the activity of a biological clock regulator in the dark and releases it with light, showing potential for future treatments of circadian-clock-related diseases.
Hokkaido University
29 Nov 2019
Scientists have discovered non-coding RNA has a novel role to fine-tune gene expressions during stress recovery, getting closer to uncovering a 30-year-old nuclear mystery.
Professor Kyung-Tai Min and Soyeon Lee
16 Aug 2019
The protein that revives injured nerve cells was discovered. It is expected to present a new direction in the development of therapeutic agents for regenerating damaged brain or spinal cord nerves.
Hokkaido University
05 Aug 2019
Two known gene mutations induce pathways that enhance pancreatic cancer’s ability to invade tissues and evade the immune system. Researchers report the molecular details of this process providing insights into druggable targets for immunotherapies.

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Researchers

Nimanthi Jayathilaka is a professor at the Department of Chemistry, University of Kelaniya, Sri Lanka.
Professor Ahmed Al-Haddad, M.Sc., Ph.D. (Germany) is currently Professor of Microbiology and Medical Microbiology at College of Medicine and Health Sciences, Hadhramout University-Yemen. He is the Founding-Dean of the first Faculty of Nursing in Yemen. He has over fifteen years of research and teaching experience in various domains of life sciences. Al-Haddad has published many peer reviewed articles and conference papers in the areas of molecular biology, microbiology and antibiotics in National and International journals. He is reviewer in different national and international Scientific Journals such as Annals of Clinical Microbiology and Antimicrobials, Journal of Microbiology and Antimicrobials, Sultan Qaboos University Medical Journal, British Biotechnology Journal. He is a member of various national and international scientific organizations.
Viteroretinal surgeon working on developing treatments for retinal dystrophies and many other retinal diseases.