Biology Molecular biology

News

20 Jul 2021
Using electron microscopy and high-speed atomic force microscopy, researchers show the internal molecular motor behind the gliding mechanism for Mycoplasma mobile to consist of two ATP synthase-like molecules. Sharing a similar structure with ATP synthase suggests a common evolutionary ancestor. This synthase-like ATPase is challenging the origin of cells and proteins themselves.
 IMAGE
14 Jul 2021
Researchers have found a way to enhance radiation therapy using novel iodine nanoparticles.
08 Jul 2021
Researchers at The University of Tokyo Institute of Industrial Science use artificial intelligence to predict the size of cells over time without the need for simplifying assumptions, which may lead to a new understanding of microbiology principles and improved drug manufacturing from recombinant bacteria
17 Jun 2021
Cryo-electron microscopy and computer simulations uncover how a cellular protein helps transport omega-3 fatty acids to the brain and eye, with implications for drug development.
Schematic view of hypoxic transcriptome meta-analysis
09 Jun 2021
Publication bias, or the tendency of researchers and journals to not publish uninteresting findings, plagues much of the natural sciences and especially biomedical research. Hiroshima University researchers have developed a meta-analytic technique exploiting publicly available transcriptome databases that avoids the problem—and in so doing, discovered four genes previously unknown to be associated with responding to low-oxygen stress.
Arabidopsis plants used in one of the experiments during the study (Photo by Takeo Sato).
28 May 2021
Scientists from Japan, Europe and the USA have described a pathway leading to the accelerated flowering of plants in low-nitrogen soils. These findings could eventually lead to increases in agricultural production.
24 May 2021
In collaboration with Kanazawa University, researchers from Osaka City University used high-speed atomic force microscopy (HS-AFM) to visualize at the nanometer level the movement of individual particles within the parasitic bacterium Mycoplasma mobile. After confirming the outline on the surface of the cell structure in an immobilized state with previous data gathered from electron microscopy, the team succeeded in visualizing the real-time movements of the internal structure by scanning the outside of the cell with HS-AFM.
14 May 2021
Researchers have observed DNA spooling and unspooling in real time using CRISPR to attach fluorescent tags to very specific DNA points in living cells.
22 Apr 2021
A mitochondrial peptide called MOCCI has a surprising sidekick, and they work together to regulate inflammation and immunity, Singapore researchers reveal.
Reverse genetics for SARS-CoV-2 by the CPER method.
13 Apr 2021
Researchers from Osaka University and Hokkaido University develop a system for analyzing mutations in SARS-CoV-2 that is much simpler and faster than existing methods.
25 Mar 2021
Researchers at Kanazawa University report in Review of Scientific Instruments a newly developed atomic force microscopy approach for imaging biological samples and processes. The method offers higher frame rates and less disturbance of samples.
Hokkaido University
19 Mar 2021
On March 19, 2021, Hokkaido University, Robotic Biology Institute Inc., iLAC Co., Ltd., and Shionogi & Co., Ltd. have entered into a memorandum of understanding (MOU) toward the establishment of an automated system for the analysis of the novel coronavirus (SARS-CoV-2) in wastewater.
Chie Nakajima, DVM, Ph.D. and Kyoko Hayashida, DVM, Ph.D.
25 Feb 2021
This article is an excerpt from the Hokkaido University research magazine “Tackling Global Issues vol.3 Fighting the menace of zoonosis" (link below).
When quiescent neural stem cells in the fruit fly larval brain are activated, they can generate new neurons. In the image, the nucleus of quiescent neural stem cells is labelled by a marker of neural stem cells named Deadpan in magenta, and the cell outline is marked in green.
11 Feb 2021
A brain enzyme activates dormant neural stem cells, revealing how defects in its gene could lead to neurodevelopmental disorders.
09 Feb 2021
Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in vivo is difficult, so the molecular mechanisms underlying the stemness of gastric tissue stem cells have remained a mystery. Here, by using organoids that mimic tissue structure and function in vivo and GeCKO screening to inactivate arbitrary genes, Alk, Bclaf3 and Prkra have been identified as genes regulating stemness.
Actin-dependent nuclear displacement observed in several mitotic mutants in fission yeast.
04 Feb 2021
Cells replicate their genetic material and divide into two identical clones to perpetuate life. Some cells pause in the process with a single, undivided nucleus. When the cell resumes division after such a pause, the nucleus can become caught in the fissure, splitting violently, and killing both cells. But that is not always the case. Researchers from Hiroshima University in Japan are starting to understand how active nuclear displacement rescues cell death.
The Asian blue tick with its eggs
28 Jan 2021
A tick saliva study reveals immune responses that could lead to better protection for cattle.
28 Dec 2020
Investigations of a cellular protein have uncovered a possible link with schizophrenia.
iCeMS Ueda ABCB1
28 Dec 2020
iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells.
23 Dec 2020
A transporter protein that regulates cell membrane cholesterol likely played an important role in vertebrate evolution, according to a review published by iCeMS researchers in the journal FEBS Letters.
19 Nov 2020
A repetitive DNA sequence that causes health risks when it malfunctions can now be watched inside living cells using a synthetic tool
06 Oct 2020
Researchers at Kanazawa University report in Nature Communications the mechanism making some lung-cancer patients resistant to the drug osimertinib. In addition, they suggest a combined drug treatment resolving osimertinib resistance in the case of cancer cells expressing low amounts of AXL, a protein belonging to the class of receptor tyrosine kinases.
28 Sep 2020
Testing self-collected saliva samples could offer an easy and effective mass testing approach for detecting asymptomatic COVID-19.
15 Sep 2020
A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.
Macrophage Activation Syndrome in COVID-19
08 Sep 2020
Scientists review macrophage activation syndrome — a feature of the cytokine storm that kills patients with severe cases of COVID-19, as well as possible treatments.
07 Sep 2020
Researchers at Kanazawa University report in Nature Communications the discovery that in the developing fly brain, neurons stemming from the same parent cell experience repulsion. This lineage-dependent repulsion is regulated by a protein known as Dscam1.
26 Aug 2020
A group of scientists have detected genetic material from SARS-CoV-2 in untreated wastewater samples collected in April 2020 from two wastewater treatment plants in Louisiana, USA.
Hypothesis for mechanism of action of IL-34 in TNBC
21 Aug 2020
Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.
Methods used to recover MHV in this study
12 Aug 2020
A group of researchers have demonstrated that, from seven methods commonly used to test for viruses in untreated wastewater, an adsorption-extraction technique can most efficiently detect SARS-CoV-2. This gives us another tool to detect the presence and spread of the COVID-19 pandemic
18 Jun 2020
Scientists are looking for ways to make millions of molecule-sized robots swarm together so they can perform multiple tasks simultaneously.

Events

30 Jul 2021
The International Union of Biochemistry and Molecular Biology (IUBMB), the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) and the College of Biochemists of Sri Lanka (CBSL), will conduct the 1st Virtual Education Symposium themed “The ‘New Normal’ Biochemistry and Molecular Biology Education”, on the 30thof July 2021.

Researchers

Dr. Tengku Haziyamin Tengku Abdul Hamid
Dr. Tengku Haziyamin Tengku Abdul Hamid's recent discovery of a novel strain has enabled a new patent to be drafted and was awarded gold medal in Malaysian Technology Expo 2021 for his new probiotic prototype called ProAquaVcare.
Nimanthi Jayathilaka is a professor at the Department of Chemistry, University of Kelaniya, Sri Lanka.
Professor Ahmed Al-Haddad, M.Sc., Ph.D. (Germany) is currently Professor of Microbiology and Medical Microbiology at College of Medicine and Health Sciences, Hadhramout University-Yemen. He is the Founding-Dean of the first Faculty of Nursing in Yemen. He has over fifteen years of research and teaching experience in various domains of life sciences. Al-Haddad has published many peer reviewed articles and conference papers in the areas of molecular biology, microbiology and antibiotics in National and International journals. He is reviewer in different national and international Scientific Journals such as Annals of Clinical Microbiology and Antimicrobials, Journal of Microbiology and Antimicrobials, Sultan Qaboos University Medical Journal, British Biotechnology Journal. He is a member of various national and international scientific organizations.
Viteroretinal surgeon working on developing treatments for retinal dystrophies and many other retinal diseases.