Biology Molecular biology
21 Aug 2023
Anti-estrogenic therapies can suppress the growth of cancer that does not express estrogen receptors; when combined with immune checkpoint inhibitor therapies, they halt tumor progression in mice models.
28 Jul 2023
Scientists have isolated potent neutralising antibodies from a COVID-19 vaccinated SARS survivor that exhibited remarkable breadth against known sarbecoviruses. The antibodies targeted a conserved region of the spike protein and blocked receptor binding and viral fusion. These findings could guide the development of broadly active therapeutics against current and future coronaviruses.
11 Jul 2023
A research team has discovered an astounding array of unexplored protein folds. This research will expand our understanding of the depth of the protein universe and the possibilities for de novo design of functional proteins.
11 Jul 2023
The entire biosynthetic pathway of actinopyridazone has been unveiled, revealing that an unprecedented carrier protein-mediated ring-forming step is key to its synthesis.
26 Jun 2023
What scientists learned about the rare antibodies targeting SARS-CoV-2’s Achilles’ heel could help fine-tune our COVID-19 vaccine strategy for longer-lasting immunity.
26 May 2023
A research team, led by researchers from Osaka University, performed genetic screening of fission yeast lacking DNA repair gene Rad51 to identify genes that play a role in gross chromosomal rearrangement (GCR), a type of mutation that occurs at the centromere. Cells lacking Srr1 or Skb1 exhibited reduced GCR, indicating that these genes are important to the occurrence of GCR. These findings advance our understanding of the mechanisms underlying centromeric GCR.
17 May 2023
A research group led by Osaka University has found that plant cells may be able to detect mechanical forces to determine their own position within the leaf—whether they are on the surface or in the inner tissues—and therefore differentiate into appropriate cell types after damage. These findings reveal how plants regenerate the correct type of tissues when damaged, and may improve our understanding of the mechanisms underlying the high regeneration potential of plants.
11 May 2023
A new group of mitochondrial viruses confined to the arbuscular mycorrhizal fungi Glomeromycotina may represent an ancestral lineage of mitoviruses.
10 May 2023
A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.
10 Apr 2023
AI finds the first stars ✨were not alone, Auto-switch for large electronic devices, A metabolite against autoimmune diseases, & Converting fruit waste 🍊🍉into solar stills. Plus in our blog: A career worth doing, a life worth living. Read all in the latest Editor's Choice.
28 Mar 2023
A group including Osaka Metropolitan University researchers discovered that the rhodopsin—a protein in the eye that detects light—of whale sharks has changed to efficiently detect blue light, which penetrates deep-sea water easily. The amino acid substitutions–one of which is counterintuitively associated with congenital stationary night blindness in humans—aid in detecting the low levels of light in the deep-sea. Although these changes make the whale shark rhodopsin less thermally stable the deep-sea temperature, allows their rhodopsin to keep working. This suggests that the unique adaptation evolved to function in the low-light low-temperature environment where whale sharks live.
15 Mar 2023
Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.
02 Mar 2023
Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.
21 Feb 2023
Sifting through sewage for SARS-CoV-2 genetic material could help authorities tailor infection control policies.
12 Feb 2023
In hepatic steatosis, hepatocytes "die," resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis predominantly causes necroptosis leading to cell rupture. This induces strong inflammation and new cell death, producing further liver damage. We reveal the transcription factor ATF3 to be involved in this process. Our results are expected to contribute to therapeutic method development.
02 Feb 2023
A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.
20 Jan 2023
Overeating mechanism: why "eating just one chip"🍟 is impossible, Measuring hidden energy of gamma-ray bursts, Marine species that can adapt to ocean acidification & A rough start can lead to a strong bond, Read all in our first Editor's Choice of 2023. Plus our interview on what dengue vaccine approval in EU💉means for global dengue protection.
11 Jan 2023
A team of Japanese researchers created a high-quality genome assembly of red perilla, a step toward harnessing the plant’s potentially useful bioactive chemicals — and its medicinal properties.
23 Dec 2022
Scientists reveal genetic mechanism associated with high-calorie food-fueled obesity
20 Dec 2022
Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.
14 Dec 2022
Using cryogenic electron microscopy, a research team from the Research Center for Artificial Photosynthesis (ReCAP) at Osaka Metropolitan University has revealed, for the first time, the structures and binding environments of pigments bound to a protein called a photosynthetic antenna of the marine green macroalga Codium fragile. The team’s results extend our knowledge about the molecular mechanism by which blue-green light—the only light available in deep seawater—is efficiently utilized for photosynthesis.
28 Nov 2022
The Sox9 gene is upregulated in the absence of sex-determining Y chromosome and Sry gene in Amami spiny rat.
10 Nov 2022
A novel branched lipid that has a high stability in storage and a high efficiency in the delivery of mRNA to cells has been developed.
01 Nov 2022
Triple-negative breast cancer (TNBC) tumors gain immunosuppression and chemoresistance through interactions between interleukin 34 and myeloid-derived suppressor cells, researchers find.
01 Nov 2022
6th NanoLSI Symposium: International symposium on Nanoprobe Technology for Understanding Molecular Systems in Kanazawa, Japan
20 Oct 2022
Giants in History: Maharani Chakravorty (1937 – 2015) was one of India’s earliest molecular biologists whose research paved the way for advances in the treatment of bacterial and viral infections.
04 Oct 2022
Metastasis—when cancer spreads to form new tumors—causes approximately 90% of cancer-related deaths. Because metastatic cancer cells circulate in the blood, the liver—which filters the blood—is considered the most vulnerable organ, so treatments that prevent liver metastasis are urgently needed. A team of Osaka Metropolitan University researchers discovered a mechanism that allows metastatic cancer cells to infiltrate the liver, and how that infiltration can be blocked by inhibiting a related protein.
29 Sep 2022
A simple and economical method of detecting SARS-CoV-2 viral loads in wastewater with high sensitivity has been developed, expanding the use of wastewater-based epidemiology for tracking the virus in populations.
08 Sep 2022
Researchers at Hiroshima University are closer to identifying the molecular processes underlying how floods deprive plants of oxygen — and how to engineer hardier crops.
01 Mar 2022 to 02 Mar 2022
The Nano Life Science Institute (WPI-NanoLSI) at Kanazawa University will hold their 5th NanoLSI Symposium 1-2 March 2022, online.
30 Jul 2021
The International Union of Biochemistry and Molecular Biology (IUBMB), the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) and the College of Biochemists of Sri Lanka (CBSL), will conduct the 1st Virtual Education Symposium themed “The ‘New Normal’ Biochemistry and Molecular Biology Education”, on the 30thof July 2021.
Dr. Crumlish has researched aquatic microbial diseases, specifically ones that have economic impact in global aquaculture, and potential solutions to such infectious diseases. Her current project seeks to develop vaccines against antimicrobial resistance in aquaculture.
Dr. Oehlers leads the Bacterial Pathogenesis Laboratory at A*STAR ID Labs, where he and his colleagues focus on identifying molecular bases of mycobacterial disease and, thus, deploy therapies that address antibiotic resistance in mycobacterial infections.
Dr. Yue Wang is senior principal investigator at the Antifungal Resistance Laboratory of A*STAR ID Labs, where his body of work focuses on virulence mechanisms of the fungal human pathogen Candida albicans.
Dr. Yan is an assistant professor at the Department of Biomedical Sciences, City University of Hong Kong (CityU). His current research focuses on developing genomic tools to dissect lncRNA function and mechanism in diseases and to identify genetic variations that contribute to disease pathogenesis.
Dr. Mitchell is a professor at the Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST). His primary research interest is the study of bacterial strains that attack and prey on other bacteria, including antimicrobial-resistant pathogens.
Dr. Soojin Jang heads the Antibacterial Resistance Research Laboratory at Institut Pasteur Korea, where her team focuses on discovering new antibacterial agents for “superbugs” or bacteria resistant to most antibiotics.
Dr. Tengku Haziyamin Tengku Abdul Hamid's recent discovery of a novel strain has enabled a new patent to be drafted and was awarded gold medal in Malaysian Technology Expo 2021 for his new probiotic prototype called ProAquaVcare.
Nimanthi Jayathilaka is a professor at the Department of Chemistry, University of Kelaniya, Sri Lanka.
Professor Ahmed Al-Haddad, M.Sc., Ph.D. (Germany) is currently Professor of Microbiology and Medical Microbiology at College of Medicine and Health Sciences, Hadhramout University-Yemen. He is the Founding-Dean of the first Faculty of Nursing in Yemen. He has over fifteen years of research and teaching experience in various domains of life sciences. Al-Haddad has published many peer reviewed articles and conference papers in the areas of molecular biology, microbiology and antibiotics in National and International journals. He is reviewer in different national and international Scientific Journals such as Annals of Clinical Microbiology and Antimicrobials, Journal of Microbiology and Antimicrobials, Sultan Qaboos University Medical Journal, British Biotechnology Journal. He is a member of various national and international scientific organizations.
Giants in history
Maharani Chakravorty (1937 – 2015) was one of India’s earliest molecular biologists whose research paved the way for advances in the treatment of bacterial and viral infections.
Motoo Kimura (13 November 1924 – 13 November 1994) was a Japanese theoretical population geneticist who is best remembered for developing the neutral theory of molecular evolution.
Gopalasamudram Narayanan Ramachandran (8 October 1922 – 7 April 2001) is best known for developing the Ramachandran plot to understand the structure of short chains of amino acids, known as peptides.
Syed Qasim Mehdi (13 February 1941 – 28 September 2016) was a Pakistani molecular biologist who was a founding member of the Human Genome Diversity Project (HGDP), which assessed human diversity by studying human migration, mutation rates, relationships between different populations, genes involved in height and selective pressure.