Biology Molecular biology

A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.

Scientists review macrophage activation syndrome — a feature of the cytokine storm that kills patients with severe cases of COVID-19, as well as possible treatments.

Researchers at Kanazawa University report in Nature Communications the discovery that in the developing fly brain, neurons stemming from the same parent cell experience repulsion. This lineage-dependent repulsion is regulated by a protein known as Dscam1.

A group of scientists have detected genetic material from SARS-CoV-2 in untreated wastewater samples collected in April 2020 from two wastewater treatment plants in Louisiana, USA.

Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.

A group of researchers have demonstrated that, from seven methods commonly used to test for viruses in untreated wastewater, an adsorption-extraction technique can most efficiently detect SARS-CoV-2. This gives us another tool to detect the presence and spread of the COVID-19 pandemic

Scientists are looking for ways to make millions of molecule-sized robots swarm together so they can perform multiple tasks simultaneously.

Research at Kanazawa University, Theragen Etex Bio Institute and Seoul National University as reported in Nature Communications points towards pathways for the metastasis and malignant transitions that result from changes in the protein p53. The results suggest that the cooperative development of mutations in the proteins helps tumours spread and metastasis.

In a recent study published in Molecular Cell, researchers at Kanazawa University report the role of cellular structures called PML bodies in regulating gene function

Researchers from Daegu Gyeongbuk Institute of Science and Technology(DGIST) have developed an innovative method that allows them to visualize up to tens of different proteins simultaneously in the same cell. This technology could help scientists elucidate the complex protein interactions involved in degenerative diseases such as Alzheimer’s, deepening our understanding of their mechanisms and allowing for early detection and treatment.

A calf was born from an embryo lacking cells which form a large part of the placenta, providing new insight into the regenerative capacity of mammalian embryos.

Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous system. The approach lies in combining two cancer drugs, with one compensating for a resistance side effect of the other.

A Chinese medicine research team at Hong Kong Baptist University (HKBU) has identified a unique polysaccharide marker from the caterpillar part of Cordyceps sinensis, and successfully applied it to the qualitative and quantitative authentication of this valuable Chinese herbal medicine. This novel, low-cost method can authenticate Cordyceps sinensis in an hour.

A hyperactive gene response to Japanese encephalitis virus infection ultimately leads to brain inflammation.

New findings could lead the way towards treatments for intellectual disability in Down syndrome.

A chemical cage suppresses the activity of a biological clock regulator in the dark and releases it with light, showing potential for future treatments of circadian-clock-related diseases.

Scientists have discovered non-coding RNA has a novel role to fine-tune gene expressions during stress recovery, getting closer to uncovering a 30-year-old nuclear mystery.

The protein that revives injured nerve cells was discovered. It is expected to present a new direction in the development of therapeutic agents for regenerating damaged brain or spinal cord nerves.

Two known gene mutations induce pathways that enhance pancreatic cancer’s ability to invade tissues and evade the immune system. Researchers report the molecular details of this process providing insights into druggable targets for immunotherapies.

Discovery of a hypersensitive suicide germination stimulant.

The actin and myosin complex (actomyosin) generates contraction force of a muscle utilizing the adenosine triphosphate (ATP) hydrolysis reaction. Many attempts have thus been made to explain the molecular origin of the actomyosin motility.