Together with her husband Imre Friedmann, she travelled around the world to study algae and other microorganisms. One of the places they visited was the Ross Desert in the Dry Valleys region of Antarctica, which was thought to be lifeless as a result of a lack of snow and ice. However, the couple discovered microorganisms, known as cryptoendoliths, that could tolerate the cold and come back to life in the summer. Ocampo-Friedmann managed to culture these microorganisms in the laboratory and NASA recognized the research as supporting the theory that microscopic life could exist on Mars because it has similar environmental conditions as Antarctica. In her lifetime, Ocampo-Friedmann collected over 1,000 types of microorganisms from extreme environments worldwide.