Dr Sarfraz Ahmed

Sarfraz Ahmed is working as a Scientist at Harvard Medical School's Mass General Hospital. His research interests include Diseases and Therapeutics especially focus on Cancer and Therapeutics, Cancer Immunology, Photomedicine, Photo compounds and Photodevices for Cancer, Cancer and Natural agents, Nanomedicine and Nanotechnology for Cancer, Drugs resistance, Microbiology (Bacteriology & Virology) and Drugs resistance

Sarfraz Ahmed is recently working as a scientist/researcher at Harvard Medical School's Mass General Hospital, USA. Before this, he was also Assistan Professor research and teaching at University of Vererinary and Animal Sciences Lahore Pakistan for his prior affiliation. He did his PhD from School of Medical Sciences, Universiti Sains Malaysia through TWAS-USM fellowship from 2011-2015. This fellowship was awarded by (TWAS) The World Academy of Sciences (UNESCO). After completing PhD he worked as an Assistant Professor Biochemistry in research and teaching at University of Veterinary and Animal Sciences Lahore Pakistan and served over a span of 5 years. His PhD dissertation focused on exploring natural agents against breast cancer in in vivo models, which included chemopreventive and therapeutic investigations. At Harvard Medical School, he is continuing to utilize his previous training in cancer’s therapeutics, immunotherapeutics, mechanisms, genomics, and immunology using new technologies and ideas by engagement of light technologies, and state-of-the-art nanotechnologies. He is probing the effects of photomedicine, specially non-invasive light for its role to boost immune system in various in vitro and in vivo cancer models. It would ultimately lead to explore new dimensions of light for boosting immune response in cancer, specially towards in clinical applications. He also edited book as a first editor on Biochemistry of Drug Resistance, which was published by publisher Springer Nature. This is a first comprehensive book on drugs resistance globally. He also edited several book chapters on drugs resistance. He has contributed around 40+ research publications in well reputed journals including like Lancet, and Nature Scientific Reports. Since having his Master dissertation in Microbiology, he continued to work in this area as well along with his major area of research in cancer. His work’s citations count as 1380 as an early career scientist. He is also a member of several international scientific associations like Biochemical Society UK, European Federation of Biochemical Societies and American Society for Microbiology. His current advisor is an internationally known personality in the field of photomedicine and oncology and immunology. His advisor’s lab demonstrated for the first time that physical cues (spiky structures) on the surface of microbes like influenza and Covid-19 viruses published in Science. He is confident that getting exposure from world’s top ranked Harvard Medical School, he will enhance his scientific art and it will help to retrieve his productivity in science towards becoming a self-reliant or excellent researcher.

Selected publications

  1. Ahmed S, Othman NH. The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study. BMC complementary and alternative medicine. 2017 Dec;17(1):1-1.
  2. Ahmed S, Sulaiman SA, Othman NH. Oral administration of Tualang and Manuka honeys modulates breast cancer progression in Sprague-Dawley rats model. Evidence-based Complementary and Alternative Medicine. 2017 Apr 5;2017.
  3. Ahmed S, Othman NH,  Sulaiman SA. Inhibitory effects of Malaysian tualang honey and Australian/New Zealand Manuka honey in modulating experimental breast cancers induced by N-methyl-N-nitrosourea (mnu): A comparative study. Pathology. 2016 Feb 1;48:S148.
  4. Othman NH, S Ahmed, Sulaiman SA. Effect of sugar concentration mimicking composition of sugars in honey on N-methyl-N-nitrosourea (MNU)-induced breast carcinoma in rats. Pathology. 2014 Jan 1;46:S55-6.
  5. Othman NH, Ahmad S,  Sulaiman SA. Inhibitory effect of Malaysian Jungle [Tualang] honey in modulating experimental breast cancers induced by N-methyl-N-nitrosourea (MNU). Pathology. 2014 Jan 1;46:S57-8.
  6. Ahmed S, Othman NH. Honey as a potential natural anticancer agent: a review of its mechanisms. Evidence-Based Complementary and Alternative Medicine. 2013 Oct;2013.
  7. Banik U, Ahamed S, Latt SS, Che Jalil NA, Wan Abdul Rahman WF, Othman NH. Pattern of Histopathological Alterations in N-methyl-NNitrosourea (MNU) Induced Breast Cancer in Female Sprague Dawley (SD) Rats Treated with Crude Honey. Pertanika Journal of Science & Technology. 2020 Oct 1;28(4).
  8. Ahmed S, Nawaz S, Murtey MD, Ibrahim M, Ahmad W, Idrees MA, Che Jalil NA, Othman NH. Evaluation of Effect of Honey Sugars Analogue Therapy against Breast Cancer Induced by 1-Methyl-1-nitrosourea in In Vivo Breast Cancer Model. Journal of Oncology. 2022 Mar 27;2022.
  9. Ahmed S, Nawaz S, Murtey MD, Ibrahim M, Ahmad W, Idrees MA, Che Jalil NA, Othman NH. Evaluation of Effect of Honey Sugars Analogue Therapy against Breast Cancer Induced by 1-Methyl-1-nitrosourea in In Vivo Breast Cancer Model. Journal of Oncology. 2022 Mar 27;2022.
  10. Shafiq I, Khalid M, Asghar MA, Baby R, Braga AA, Alshehri SM, Ahmed S. Influence of azacycle donor moieties on the photovoltaic properties of benzo [c][1, 2, 5] thiadiazole based organic systems: a DFT study. Nature Scientific Reports. 2023 Sep 5;13(1):14630.
  11. Ahmed, Sarfraz, and Nor Hayati Othman. "Honey as a potential natural anticancer agent: a review of its mechanisms." Evidence-Based Complementary and Alternative Medicine 2013 (2013).
  12. Global, NIHR Global Health Unit, et al. "Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries." The Lancet 400.10363 (2022): 1607-1617.
  13. Ibrahim M, Munir S, Ahmed S, Chughtai AH, Ahmad W, Khan J, Murtey MD, Ijaz H, Ojha SC. Gliclazide in Binary and Ternary Systems Improves Physicochemical Properties, Bioactivity, and Antioxidant Activity. Oxidative Medicine and Cellular Longevity. 2022 Nov 25;2022.
  14. Ahmed, Sarfraz, Siti Amrah Sulaiman, and Nor Hayati Othman. "Effect of Apis Dorsata honey and honey sugars analogue on hematological and some biochemical parameters in albino rats model." Asia-Pacific Journal of Science and Technology 23, no. 2 (2018).
  15. Shah M, Khaliq F, Nawaz H, Rahim F, Ullah N, Javed Ms, Amjad A, Nishan U, Ullah S, Ahmed S, Jalil Na. Comparative evaluation of proximate composition and biological activities of peel extracts of three commonly consumed fruits. FSC and Technology. 2022 May 13;42.
  16. Ahmed S, Othman NH. Review of the medicinal effects of tualang honey and a comparison with manuka honey. The Malaysian journal of medical sciences: MJMS. 2013 May;20(3):6.
  17. Khalid M, Hanif S, Ahmed S, Asghar MA, Imran M, Braga AA, Ojha SC. Exploration of Nonlinear Optical Behavior in Asymmetric Dithieno [3, 2b: 2′, 3′ d] pyrrole based Push Pull Constrain: A Theoretical Approach. Journal of Saudi Chemical Society. 2023 May 8:101650.
  18. Abro, Muhammad Nawaz, Muhammad Ejaz Khan, Muhammad Ibrahim, Greesh Kumar Maheshwari, Ghulam Asghar, Sarfraz Ahmed, Muhammad Qasim et al. "Incidence of Colorectal Carcinoma in the Remote Area of Sindh, Pakistan." Advancements in Life Sciences 9, no. 4 (2023): 539-546.
  19. Mashhadi SM, Bhatti MH, Jabeen E, Yunus U, Ashfaq M, Akhtar M, Tahir MN, Alshehri SM, Ahmed S, Ojha SC. Synthesis and Antioxidant studies of 2, 4-dioxothiazolidine-5-acetic acid based organic salts: SC-XRD and DFT approach. ACS omega. 2023 Aug 7;8(33):30186-98.
  20. Khan MU, Ibrahim M, Khalid M, Braga AA, Ahmed S, Sultan A. Prediction of second-order nonlinear optical properties of D–π–A compounds containing novel fluorene derivatives: a promising route to giant hyperpolarizabilities. Journal of Cluster Science. 2019 Mar;30(2):415-30.
  21. Muhammad Haroon, Tashfeen Akhtar, Muhammad Khalid, Hasnain Mehmood, Muhammad Adnan Asghar, Tansir Ahamad, Sarfraz Ahmed & Ataualpa A. C. Braga. Synthesis, Spectroscopic and Quantum Chemical Studies of N-Pentylhydrazinylthiazole Derivatives, Polycyclic Aromatic Compounds.2023 Jul.2023.
  22. Iqra Shafiq, Izza Amanat, Muhammad Khalid, Muhammad Adnan Asghar, Rabia Baby, Sarfraz Ahmed, Saad M. Alshehri, Influence of azo-based donor modifications on nonlinear optical amplitude of D-π-A based organic chromophores:A DFT/TD-DFT exploration. Synthetic Metals.2023:297.117410.25.
  23. Shafiq, Iqra, Ume Habiba Ishaque, Muhammad Khalid, Ataualpa Albert Carmo Braga, Muhammad Adnan Asghar, Saad M. Alshehri, Sarfraz Ahmed, and Suvash Chandra Ojha. "A Theoretical Approach for Exploration of Non-linear Optical Amplification of Fused Azacycle Donor Based Thiophene Polymer Functionalized Chromophores." Journal of Saudi Chemical Society (2023): 101707.
  24. Ali B, Khalid M, Asim S, Usman Khan M, Iqbal Z, Hussain A, Hussain R, Ahmed S, Ali A, Hussain A, Imran M. Key electronic, linear and nonlinear optical properties of designed disubstituted quinoline with carbazole compounds. Molecules. 2021 Jan;26(9):2760.
  25. Haroon M, Akhtar T, Khalid M, Mehmood H, Braga AA, Alhokbany N, Ahmed S. Experimental and Quantum Chemical Studies of Hydrazonebased Organic Chromophores: Synthesis, Spectroscopic and Nonlinear Optical Properties. ChemistrySelect. 2023 Jul 26;8(28):e202301209.
  26. Khan I, Adeel M, Ahamad T, Khan MS, Schnakenburg G, Ahmed S, Ojha SC, Asghar MA. Synthesis, Characterization, and DFT Study of Mono-and Di-Arylated Pyridine Derivatives. Polycyclic Aromatic Compounds. 2023 Sep 12:1-24.
  27. Khalid M, Maqsood R, Shafiq I, Baby R, Asghar MA, Ahmed S, Alshehri SM, Braga AA. Theoretical Approach towards Benzodithiophene-Based Chromophores with Extended Acceptors for Prediction of Efficient Nonlinear Optical Behaviour. Arabian Journal for Science and Engineering. 2023 Jul 31:1-21.
  28. Chen K, Ahmed S, Sheng YJ, Sun C, Deng CL, Ojha SC. Diagnostic accuracy of nucleic acid amplification-based assays for Clostridium perfringens-associated diseases: A systematic review and meta-analysis. Journal of clinical microbiology. 2020 Aug 24;58(9):e00363-20.
  29. Shafiq I, Mustafa A, Zahid R, Baby R, Ahmed S, Asghar MA, Ahamad T, Alam M, Braga AA, Ojha SC. Theoretical Perspective toward Designing of 5-Methylbenzo [1, 2-b: 3, 4-b′: 6, 5-b ″] trithiophene-Based Nonlinear Optical Compounds with Extended Acceptors. ACS Omega. 2023 Oct.
  30. Chen K, Malik AA, Nantasenamat C, Ahmed S, Chaudhary O, Sun C, Sheng YJ, Chen W, Gang W, Deng CL, Ojha SC. Clinical validation of urine-based Xpert® MTB/RIF assay for the diagnosis of urogenital tuberculosis: a systematic review and meta-analysis. International Journal of Infectious Diseases. 2020 Jun 1;95:15-21.
  31. Yue, Yuan, Ke Chen, Changfeng Sun, Sarfraz Ahmed, and Suvash Chandra Ojha. "Antimicrobial peptidase lysostaphin at subinhibitory concentrations modulates staphylococcal adherence, biofilm formation, and toxin production." BMC microbiology 23, no. 1 (2023): 311.
  32. Ojha SC, Chen K, Yuan Y, Ahmed S, Malik AA, Nisha M, Sheng YJ, Sun C, Wu G, Deng CL. Clinical relevance of molecular testing methods in the diagnosis and guidance of therapy in patients with staphylococcal empyema: a systematic review and meta-analysis. Frontiers in cellular and infection microbiology. 2022:1079.
  33. Ahmed S, Ibrahim M, Nantasenamat C, Nisar MF, Malik AA, Waheed R, Ahmed MZ, Ojha SC, Alam MK. Pragmatic Applications and Universality of DNA Barcoding for Substantial Organisms at Species Level: A Review to Explore a Way Forward. BioMed Research International. 2022 Jan 11;2022.
  34. Chen K, Wang Y, Yuan Y, Qin W, Sheng YJ, Ahmed S, Sun C, Deng CL, Ojha SC. Molecular Tools for Guiding Therapy in Patients With Staphylococcal Bone and Joint Infections: A Diagnostic Test Accuracy Meta-analysis. Frontiers in Endocrinology. 2022;13.
  35. Jaan S, Shah M, Ullah N, Amjad A, Javed MS, Nishan U, Mustafa G, Nawaz H, Ahmed S, Ojha SC. Multi-epitope chimeric vaccine designing and novel drug targets prioritization against multi-drug resistant Staphylococcus pseudintermedius. Frontiers in microbiology. 2022;13.
  36. Jaan S, Zaman A, Ahmed S, Shah M, Ojha SC. mRNA Vaccine Designing Using Chikungunya Virus E Glycoprotein through Immunoinformatics-Guided Approaches. Vaccines. 2022 Sep 6;10(9):1476.
  37. Munir S, Ahmed S, Ibrahim M, Khalid M, Ojha SC. A Spellbinding interplay between biological barcoding and nanotechnology. Frontiers in Bioengineering and Biotechnology. 2020 Sep 8;8:883.
  38. Ahmed S, Ullah N, Parveen S, Javed I, Jalil NA, Murtey MD, Sheikh IS, Khan S, Ojha SC, Chen K. Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniature Clinical Trial. Oxidative Medicine and Cellular Longevity. 2022 Feb 2;2022.
  39. Liu, Xilin, Zeeshan Nawaz, Caixia Guo, Sultan Ali, Muhammad Ahsan Naeem, Tariq Jamil, Waqas Ahmad S Ahmed. "Rabies virus exploits cytoskeleton network to cause early disease progression and cellular dysfunction." Frontiers in Veterinary Science 9 (2022): 889873.
  40. Ahmed, Sarfraz, Adeela Zahoor, Muhammad Ibrahim, Muhammad Younus, Sadia Nawaz, Rahat Naseer, Qaiser Akram, Cun-Liang Deng, and Suvash Chandra Ojha. "Enhanced efficacy of direct-acting antivirals in hepatitis C patients by coadministration of black cumin and ascorbate as antioxidant adjuvants." Oxidative Medicine and Cellular Longevity 2020 (2020).
Sarfraz Ahmed
United States
Wellman Centre for Photomedicine, Harvard Medical School
Academic disciplines: