Biology Biochemistry

News

Answering a century-old question on the origins of life
27 Sep 2021
The missing link isn’t a not-yet-discovered fossil, after all. It’s a tiny, self-replicating globule called a coacervate droplet, developed by two researchers in Japan to represent the evolution of chemistry into biology.
15 Sep 2021
Using the lamprey, researchers from Japan analyzed the photosensory mechanism of the pineal organ, also called the pineal gland, in non-mammalian vertebrates and discovered a novel mechanism of pineal color discrimination (two-cell system) in which two types of photoreceptor cells, each containing two different opsins, are used to detect color. This discovery may provide insight into the evolution of color detection in other animals, including color vision in humans.
IMAGE
13 Sep 2021
iCeMS scientists and colleagues have designed a molecular code that powers up cancer-fighting immune cells.
26 Aug 2021
A multi-functional, small molecule can tag mutant genetic sequences inside mitochondria for removal.
Model of translation initiation and its control by 5MP
17 Aug 2021
Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease. But the process can deregulate and give rise to disease. Byproducts of errant processes can build up like gunk in the gears, especially around neurons, breaking down the repair mechanisms and causing further damage and even neurodegenerative disorders such as Alzheimer’s disease.
 IMAGE
14 Jul 2021
Researchers have found a way to enhance radiation therapy using novel iodine nanoparticles.
13 Jul 2021
Researchers from Osaka City University show the benefits of mixing alginic acid with calcium phosphate cement (CPC), a common bone replacement material, with in vitro and in vivo studies. The biopolymer is shown to improve the setting time and compressive strength of CPC, as well as help it acquire porosity – which allows cells to enter the defected area and grow new bone.
08 Jul 2021
Researchers at The University of Tokyo Institute of Industrial Science use artificial intelligence to predict the size of cells over time without the need for simplifying assumptions, which may lead to a new understanding of microbiology principles and improved drug manufacturing from recombinant bacteria
05 Jul 2021
Researchers analyze bone marrow-derived and peripheral blood-derived fibrin clots showing that the former contains more growth factors. They then show that bone marrow-derived fibrin clots can be used for meniscus suturing, even in the inner-most avascular regions, and with a 2-year post-operative follow-up, they show bone marrow-derived fibrin clots support healing better than their peripheral blood counterparts.
Schematic view of hypoxic transcriptome meta-analysis
09 Jun 2021
Publication bias, or the tendency of researchers and journals to not publish uninteresting findings, plagues much of the natural sciences and especially biomedical research. Hiroshima University researchers have developed a meta-analytic technique exploiting publicly available transcriptome databases that avoids the problem—and in so doing, discovered four genes previously unknown to be associated with responding to low-oxygen stress.
IMAGE
31 May 2021
High-resolution genome structural analyses combined with large-scale simulations show the arrangements of the genome’s spool-like structures affecting gene expression.
14 May 2021
Upcoming Solar System exploration missions will search for extraterrestrial (ET) life, but ET life may not be like Earth life. A new mass spectrometry analysis technique may allow for process-based ways to find ET life that is compositionally alien.
PD-L1 immunohistochemical staining in typical oral malignant melanoma (left) and squamous cell skin cancer (right)
22 Apr 2021
Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.
15 Apr 2021
Researchers from The University of Tokyo develop a novel device for the safe and effective transplantation of human induced pluripotent stem cell (iPSC)-derived pancreatic beta-cells in type I diabetes mellitus
Human brain cancer cells forming spherical structures on the DN gel
29 Mar 2021
A hydrogel, a type of soft matter, developed at Hokkaido University successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human cancer types. This could lead to the development of anti-cancer stem cell drugs and personalized medicines.
11 Jan 2021
Researchers at Kanazawa University report in Communications Chemistry that a molecule known as pillar[6]arene can form a host–guest compound with a cancer-associated metabolite. The phenomenon can be used to efficiently detect the metabolite in crude biological samples, which is important for preventing and treating metabolic syndrome and associated pathologies.
07 Jan 2021
Factor-pooling by ribosomes caught on video using state-of-art high-speed atomic force microscopy technology.
28 Dec 2020
Investigations of a cellular protein have uncovered a possible link with schizophrenia.
iCeMS Ueda ABCB1
28 Dec 2020
iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells.
24 Dec 2020
Researchers at WPI-IIIS find that normal sleep in mice depends on bacteria that help make neurotransmitters such as serotonin in the gut. The article, “Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice,” was published in Scientific Reports.
23 Dec 2020
A transporter protein that regulates cell membrane cholesterol likely played an important role in vertebrate evolution, according to a review published by iCeMS researchers in the journal FEBS Letters.
Turning off gene editing during error-prone cell cycle phases
04 Dec 2020
Turning off gene-editing until it reaches cell cycle phases where more accurate repairs are likely to happen offers a promising fix to CRISPR-Cas9’s problem with unwanted genetic changes.
19 Nov 2020
A repetitive DNA sequence that causes health risks when it malfunctions can now be watched inside living cells using a synthetic tool
Broken Hill Mine, Kabwe
04 Nov 2020
Residents of Kabwe Town, Zambia, have very high blood levels of lead and cadmium, to such an extent that the symptoms of toxicity have been clinically observed.
Lysosomes in a breast cancer cell.
29 Oct 2020
Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.
01 Oct 2020
Scientists have found an ingredient that makes a vaccine more effective through an approach more often seen in materials science – testing molecules that self-assemble into larger structures.
28 Sep 2020
Researchers from the University of Tsukuba demonstrate that the hypnotic and teratogenic effects of thalidomide are separable. Thalidomide is a medication with several different effects, one of which is promoting sleep in the context of insomnia. In a new study, researchers from the University of Tsukuba have discovered that thalidomide exerts its hypnotic effects through mechanisms distinct from those for the drug’s notorious teratogenicity. These are striking results showing how thalidomide induces sleep independently of its known effects on the teratogenic cereblon pathway. These findings could be helpful in developing novel thalidomide-like hypnotic drugs without thalidomide’s teratogenic effects. The study was published in the scientific journal Proceedings of the National Academy of Sciences of the United States of America.
Scientists who contributed to this research
07 Aug 2020
Scientists have unveiled a correlation between high blood lead levels in children and methylation of genes involved in haem synthesis and carcinogenesis, indicating a previously unknown mechanism for lead poisoning.
03 Aug 2020
Researchers at Kanazawa University report in ACS Nano a high-speed atomic-force microscopy study of the formation of protein fibrils (amyloids) associated with pathologies in collaborated research with Showa University. Mixing different variants of a single protein and changing the acidity of its environment is shown to result in significant variations in amyloid structure and elongation rates.
iCeMS hasegawa malaria india
02 Jul 2020
A method that involves infecting liver cells with mosquito-bred parasites could improve the study of malaria in India.

Events

30 Jul 2021
The International Union of Biochemistry and Molecular Biology (IUBMB), the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) and the College of Biochemists of Sri Lanka (CBSL), will conduct the 1st Virtual Education Symposium themed “The ‘New Normal’ Biochemistry and Molecular Biology Education”, on the 30thof July 2021.

Researchers

Prof. Chen Sheng
Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields
Dr. Indika, Neluwa-Liyanage is a lecturer at the Faculty of Medical Sciences of University of Sri Jayewardenepura. His research focuses on pathogenesis and metabolic profile of autism spectrum disorder. He has also collaborated actively with international researchers in the field of inherited metabolic disorders.
Dr NK Prasanna
Dr NK Prasanna is currently working as Scientist & Editor, Indian Journal of Biochemistry & Biophysics, Research Journals Division at CSIR-National Institute of Science Communication and Policy Research, New Delhi since December 2016. Before joining CSIR (NIScPR), she was at IIT Guwahati. Dr Prasanna completed her Ph.D from Institute of Medical Sciences, Banaras Hindu University, Varanasi. In CSIR-NIScPR, She served one important flagship journals viz. Indian journal of Biochemistry and Biophysics (IJBB; ISSN: 0301-1208) It is pertinent to mention that the journal ranks first among all the NIScPR journals as per the available Journal Metrics by international agencies such as Thomson Reuters and Scopus. Details of remarkable academic achievements of IJBB which she spearheading, both nationally and globally. The Indian journal of Biochemistry and Biophysics (IJBB) is a premier SCI-indexed bimonthly peer-reviewed research journal that publishes original research articles in the subject area of biochemistry and biophysics