Biology Biochemistry

News

Schematic illustrations of cargo transport by a swarm of molecular robots (top) and fluorescence images of a molecular robot transporting blue sphere-like cargo (bottom). The scale bar is 20 micrometers. By specifying the position of the light irradiation, it is possible to accumulate the cargo at the designated destination (right). The scale bar is 50 micrometers (Mousumi Akter, et al. Science Robotics. April 20, 2022).
20 Apr 2022
In a global first, scientists have demonstrated that molecular robots are able to accomplish cargo delivery by employing a strategy of swarming, achieving a transport efficiency five times greater than that of single robots.
12 Apr 2022
Researchers at Kanazawa University elucidate in Frontiers in Molecular Biosciences how small biocontainers enclosed by membranes are involved in a disease called ATTRv amyloidosis.
07 Apr 2022
The molecule trimethylamine N-oxide (TMAO) can be used to reversibly modulate the rigidity of microtubules, a key component of molecular machines and molecular robots.
The cancer stem cells cultured on the DN gel formed a tumor when injected into mice brain.
11 Mar 2022
A soft hydrogel could help scientists find treatments for drug-resistant cancer stem cells.
Pain neuron-derived Reg3γ protects brain metabolism of LPS challenged mice (Kenta Maruyama).
08 Mar 2022
A research team led by the National Institute for Physiological Sciences and joined by Hokkaido University explored the role of pain neurons in the regulation of endotoxic death. They found that peptide named Reg3γ acts as a pain neuron-enriched brain-targeted hormone that protects the host from endotoxic death.
(Top) The star-polymer-DNA-gel (left) liquifies when its temperature is increased to more than 70˚C (center), and returns to a gel when the temperature drops back to 25˚C (right). (Bottom) Under UV light, the star-polymer-DNA-gel fluoresces green (left, right), but does not fluoresce when liquified (Photo: Xiang Li).
16 Feb 2022
Simulations have led to the fabrication of a polymer-DNA gel that could be used in tissue regeneration and robotics.
Giants in History: Eminent Filipina scientist and educator Clara Lim-Sylianco
10 Feb 2022
Giants in History: Eminent Filipina scientist and educator Clara Lim-Sylianco (18 August 1925 – 23 July 2013) is remembered for her extensive research on mutagens – often-carcinogenic agents that permanently alter genetic materials such as DNA – antimutagens and bioorganic mechanisms.
Kamala Sohonie
26 Jan 2022
Giants in History: In 1939, biochemist Kamala Sohonie (18 June 1911 – 28 June 1998) became the first woman to be accepted into the Indian Institute of Science (IISc).
Figure 1. Mass Imaging.
06 Jan 2022
Enzymatic hydrolysis of planteose: α-Galactosidase is a promising molecular target for root parasitic weed control
Allergic reaction and immune tolerance mechanism
22 Dec 2021
Scientists have identified a series of molecular candidates for those parts of dog allergens that cause immune reactions in people—the first step in developing a vaccine against most causes of dog allergies.
Julian Banzon
07 Dec 2021
Julian Arca Banzon (13 March 1908 – 13 September 1988) was a biochemist from the Philippines who was a pioneer in alternative fuel research.
Answering a century-old question on the origins of life
27 Sep 2021
The missing link isn’t a not-yet-discovered fossil, after all. It’s a tiny, self-replicating globule called a coacervate droplet, developed by two researchers in Japan to represent the evolution of chemistry into biology.
15 Sep 2021
Using the lamprey, researchers from Japan analyzed the photosensory mechanism of the pineal organ, also called the pineal gland, in non-mammalian vertebrates and discovered a novel mechanism of pineal color discrimination (two-cell system) in which two types of photoreceptor cells, each containing two different opsins, are used to detect color. This discovery may provide insight into the evolution of color detection in other animals, including color vision in humans.
IMAGE
13 Sep 2021
iCeMS scientists and colleagues have designed a molecular code that powers up cancer-fighting immune cells.
26 Aug 2021
A multi-functional, small molecule can tag mutant genetic sequences inside mitochondria for removal.
Model of translation initiation and its control by 5MP
17 Aug 2021
Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease. But the process can deregulate and give rise to disease. Byproducts of errant processes can build up like gunk in the gears, especially around neurons, breaking down the repair mechanisms and causing further damage and even neurodegenerative disorders such as Alzheimer’s disease.
 IMAGE
14 Jul 2021
Researchers have found a way to enhance radiation therapy using novel iodine nanoparticles.
13 Jul 2021
Researchers from Osaka City University show the benefits of mixing alginic acid with calcium phosphate cement (CPC), a common bone replacement material, with in vitro and in vivo studies. The biopolymer is shown to improve the setting time and compressive strength of CPC, as well as help it acquire porosity – which allows cells to enter the defected area and grow new bone.
08 Jul 2021
Researchers at The University of Tokyo Institute of Industrial Science use artificial intelligence to predict the size of cells over time without the need for simplifying assumptions, which may lead to a new understanding of microbiology principles and improved drug manufacturing from recombinant bacteria
05 Jul 2021
Researchers analyze bone marrow-derived and peripheral blood-derived fibrin clots showing that the former contains more growth factors. They then show that bone marrow-derived fibrin clots can be used for meniscus suturing, even in the inner-most avascular regions, and with a 2-year post-operative follow-up, they show bone marrow-derived fibrin clots support healing better than their peripheral blood counterparts.
Schematic view of hypoxic transcriptome meta-analysis
09 Jun 2021
Publication bias, or the tendency of researchers and journals to not publish uninteresting findings, plagues much of the natural sciences and especially biomedical research. Hiroshima University researchers have developed a meta-analytic technique exploiting publicly available transcriptome databases that avoids the problem—and in so doing, discovered four genes previously unknown to be associated with responding to low-oxygen stress.
IMAGE
31 May 2021
High-resolution genome structural analyses combined with large-scale simulations show the arrangements of the genome’s spool-like structures affecting gene expression.
14 May 2021
Upcoming Solar System exploration missions will search for extraterrestrial (ET) life, but ET life may not be like Earth life. A new mass spectrometry analysis technique may allow for process-based ways to find ET life that is compositionally alien.
PD-L1 immunohistochemical staining in typical oral malignant melanoma (left) and squamous cell skin cancer (right)
22 Apr 2021
Scientists have shown that the biological molecule PD-L1 is a potential target for the treatment of metastasized oral malignant melanoma in dogs.
15 Apr 2021
Researchers from The University of Tokyo develop a novel device for the safe and effective transplantation of human induced pluripotent stem cell (iPSC)-derived pancreatic beta-cells in type I diabetes mellitus
Human brain cancer cells forming spherical structures on the DN gel
29 Mar 2021
A hydrogel, a type of soft matter, developed at Hokkaido University successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human cancer types. This could lead to the development of anti-cancer stem cell drugs and personalized medicines.
11 Jan 2021
Researchers at Kanazawa University report in Communications Chemistry that a molecule known as pillar[6]arene can form a host–guest compound with a cancer-associated metabolite. The phenomenon can be used to efficiently detect the metabolite in crude biological samples, which is important for preventing and treating metabolic syndrome and associated pathologies.
07 Jan 2021
Factor-pooling by ribosomes caught on video using state-of-art high-speed atomic force microscopy technology.
28 Dec 2020
Investigations of a cellular protein have uncovered a possible link with schizophrenia.
iCeMS Ueda ABCB1
28 Dec 2020
iCeMS scientists have revealed how a transporter protein twists and squeezes compounds out of cells, including chemotherapy drugs from some cancer cells.

Events

30 Jul 2021
The International Union of Biochemistry and Molecular Biology (IUBMB), the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) and the College of Biochemists of Sri Lanka (CBSL), will conduct the 1st Virtual Education Symposium themed “The ‘New Normal’ Biochemistry and Molecular Biology Education”, on the 30thof July 2021.

Researchers

Picture of Ann-Marie Chacko
Prof. Ann Marie Chacko lead the translational efforts for a portfolio of in vivo PET, SPECT, CT and optical imaging agents that span key therapeutic areas including oncology, immunology, infectious disease and neurobiology.
Prof. Chen Sheng
Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields
Dr. Indika Neluwa-Liyanage is a lecturer in Biochemistry at the Faculty of Medical Sciences of University of Sri Jayewardenepura. His research focuses on the metabolic alterations underlying autism spectrum disorders and inherited metabolic disorders.
Dr NK Prasanna
Dr NK Prasanna is currently working as Sr. Scientist & Scientific Editor, Indian Journal of Biochemistry & Biophysics, Research Journals Division at CSIR-National Institute of Science Communication and Policy Research, New Delhi since December 2016. Before joining CSIR (NIScPR), she was at IIT Guwahati. Dr Prasanna completed her Ph.D from Institute of Medical Sciences, Banaras Hindu University, Varanasi. In CSIR-NIScPR, She served one important flagship journals viz. Indian journal of Biochemistry and Biophysics (IJBB; ISSN: 0301-1208) It is pertinent to mention that the journal ranks first among all the NIScPR journals as per the available Journal Metrics by international agencies such as Thomson Reuters and Scopus. Details of remarkable academic achievements of IJBB which she spearheading, both nationally and globally. The Indian journal of Biochemistry and Biophysics (IJBB) is a premier SCI-indexed bimonthly peer-reviewed research journal that publishes original research articles in the subject area of biochemistry and biophysics