Prof. Chen Sheng

Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields

His research lies on the interface of clinical study and basic science using multi-disciplinary approaches including Genomics, Genetics, Biochemistry, Cell Biology and Chemical Biology with the ultimate goal of developing novel therapies to combat bacterial antimicrobial resistance.

Education

PhD in Food Microbiology, University of Maryland, USA (2004)
Masters of Preventive Veterinary Medicine, China Agriculture University, China (2000)
Bachelors in Veterinary, China Agriculture University, China (1997)

Research Interests

His research lies on the interface of clinical study and basic science using multi-disciplinary approaches including Genomics, Genetics, Biochemistry, Cell Biology and Chemical Biology with the ultimate goal of developing novel therapies to combat bacterial antimicrobial resistance.

 

Selected publications

Zhang R, Dong N, Shen ZQ, Zeng Y, Lu JY, Liu CC, Zhou HW, Hu YY, Sun QL, Cheng QP, Shu LB, Cai JC, Chan EWC, Chen GX, Chen S*.
Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X).
Nature Communications. Nat Commun. 2020 Sep 16;11

Sun, Z., Shang, Z., Forelli, N., Po, K. H. L., Chen, S., Brady, S. F. & Li, X.
Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation Mediated Cyclization and Absolute Structure Establishment. 29 Jul 2020.
Angewandte Chemie-International Edition. DOI: 10.1002/anie.202009092 (IF=12.96)

Yang, X., Dong, N., Chan, E. W., Zhang, R. & Chen, S*.
Carbapenem Resistance-Encoding and Virulence-Encoding Conjugative Plasmids in Klebsiella pneumoniae. 21 May 2020
Trends in Microbiology. Trends Microbiol. 2020 May 21:S0966-842X(20)30105-0. DOI: 10.1016/j.tim.2020.04.012

Qiu, J., Nie, Y., Zhao, Y., Zhang, Y., Li, L., Wang, R., Wang, M., Chen, S., Wang, J., Li, Y. & Xia, J.
Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism. 10 Mar 2020
Proceedings of the National Academy of Sciences of the United States of America. 2020 Mar 10;117(10):5260-5268. DOI: 10.1073/pnas.1914567117

Yang X, Ye L, Chan EW, Zhang R, Chen S*.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
mSystems. 2020 Jul 14;5(4):e00140-20. DOI: 10.1128/mSystems.00140-20

 

For more publications, please visit:

https://www.cityu.edu.hk/ph/staff/professor-sheng-chen

 

Prof. Chen Sheng
Languages: 
Chinese
English
Academic disciplines: 
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