Biology Cell biology
22 Dec 2021
We have succeeded in establishing a mouse model that develops gastric cancer closely resembling advanced human gastric cancer. Using this model, we have discovered gastric cancer stem cells, i.e. Lgr5+ gastric cancer cells, essential for the development, maintenance, and metastasis of cancer. Our study provides an experimental system that enables detailed analysis of highly malignant gastric cancer and is expected to lead to the development of a breakthrough treatment for advanced human gastric cancer.
15 Dec 2021
Zika virus infection hijacks glucose metabolism for its own good and to the detriment of infected foetuses.
08 Nov 2021
We have clarified at the molecular level the mechanism by which a microenvironment, a so-called niche that surrounds cancer cells, is formed in which stromal cells and immune cells are attracted at an initiation stage of breast cancer onset. A molecule called FRS2β is found to be critical for creating this microenvironment. The present finding is expected to be beneficial in prevention, diagnosis and treatment of cancers at the initiation stage.
02 Nov 2021
Malfunctioning of the so-called Hippo signalling pathway within animal cells leads to irregular activity of proteins that regulate genes involved in cell proliferation. Researchers have identified a key step in the process of this aberration, opening the door to new therapeutics for cancers such as head-and-neck squamous cell carcinoma and lung adenocarcinoma.
02 Nov 2021
The world’s largest analysis of gastric tumour cells provides a launch pad for scientists to plan more effective therapies.
14 Oct 2021
Researchers from The University of Tokyo Institute of Industrial Science describe a novel feature of the immune response to certain viruses such as measles
27 Sep 2021
The missing link isn’t a not-yet-discovered fossil, after all. It’s a tiny, self-replicating globule called a coacervate droplet, developed by two researchers in Japan to represent the evolution of chemistry into biology.
15 Sep 2021
Using the lamprey, researchers from Japan analyzed the photosensory mechanism of the pineal organ, also called the pineal gland, in non-mammalian vertebrates and discovered a novel mechanism of pineal color discrimination (two-cell system) in which two types of photoreceptor cells, each containing two different opsins, are used to detect color. This discovery may provide insight into the evolution of color detection in other animals, including color vision in humans.
15 Sep 2021
New research published in Stem Cell Reports has found elevated cholesterol supply from astrocytes to neurons in the model of Alzheimer's disease (AD) brains, suggesting that modulating brain cholesterol could be explored in the search of treatment options for the devastating, degenerative disease.
13 Sep 2021
iCeMS scientists and colleagues have designed a molecular code that powers up cancer-fighting immune cells.
17 Aug 2021
Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease. But the process can deregulate and give rise to disease. Byproducts of errant processes can build up like gunk in the gears, especially around neurons, breaking down the repair mechanisms and causing further damage and even neurodegenerative disorders such as Alzheimer’s disease.
20 Jul 2021
Using electron microscopy and high-speed atomic force microscopy, researchers show the internal molecular motor behind the gliding mechanism for Mycoplasma mobile to consist of two ATP synthase-like molecules. Sharing a similar structure with ATP synthase suggests a common evolutionary ancestor. This synthase-like ATPase is challenging the origin of cells and proteins themselves.
14 Jul 2021
Researchers have found a way to enhance radiation therapy using novel iodine nanoparticles.
08 Jul 2021
Researchers at The University of Tokyo Institute of Industrial Science use artificial intelligence to predict the size of cells over time without the need for simplifying assumptions, which may lead to a new understanding of microbiology principles and improved drug manufacturing from recombinant bacteria
28 Jun 2021
A new non-invasive technique scans “chemical fingerprints” to see if ordinary cells’ reprogramming into stem cells is on track and verify transformation success by matching “print” patterns.
14 Jun 2021
A team of scientists has shown that the healing of skin blisters is driven by hair follicle stem cells, which delay their own development in the process.
11 Jun 2021
• Glioblastoma (GBM) is a highly aggressive type of brain cancer. Even with current standard of care, 50% of patients die within 15 months of diagnosis. • This complex cancer is difficult to treat due to its location, structure, ability to spread quickly, high recurrence rate and severely limited treatment options. • GBM tumours can look identical under the microscope but respond differently to the same treatment. • With a national grant of about S$10 million, researchers in Singapore are working with overseas collaborators to address these challenges and develop new diagnostic and treatment options so patients can receive effective targeted therapy.
07 Jun 2021
The chances of restoring fertility through sperm stem cell transplant are as random as a coin toss. But a team of scientists developed a new strategy that serves as a “weighted coin” that can favorably rig the odds to achieve outcomes where fertility is successfully restored.
31 May 2021
High-resolution genome structural analyses combined with large-scale simulations show the arrangements of the genome’s spool-like structures affecting gene expression.
24 May 2021
In collaboration with Kanazawa University, researchers from Osaka City University used high-speed atomic force microscopy (HS-AFM) to visualize at the nanometer level the movement of individual particles within the parasitic bacterium Mycoplasma mobile. After confirming the outline on the surface of the cell structure in an immobilized state with previous data gathered from electron microscopy, the team succeeded in visualizing the real-time movements of the internal structure by scanning the outside of the cell with HS-AFM.
21 May 2021
Single-cell gene studies are clarifying the roles of the brain’s specialised immune cell in Alzheimer’s disease and offer new avenues for treatment of this incurable condition.
07 May 2021
A group of researchers have discovered that the cells that line the surfaces of organs or specific tissues – epithelial cells – asymmetrically release two types of exomes with distinct protein compositions. Their discovery could help understand how cancer spreads.
14 Apr 2021
Prof. June.M. Kwak, and Prof. Chang-Hee Cho are selected for the research funds granted by Samsung Science & Technology Foundation
26 Mar 2021
An ‘eat-me’ signal displayed on cell surfaces requires activation of a lipid-scrambling protein by a nuclear protein fragment.
16 Mar 2021
New research from Duke-NUS Medical School, and the Agency for Science, Technology and Research identifies chemotherapy-resistant cancers’ escape mechanism, which offers new anti-cancer treatment options.
02 Mar 2021
Researchers at The University of Tokyo develop a method of culturing meat in the laboratory in the form of millimeter-scale contractile beef muscle that closely simulates steak meat
09 Feb 2021
Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in vivo is difficult, so the molecular mechanisms underlying the stemness of gastric tissue stem cells have remained a mystery. Here, by using organoids that mimic tissue structure and function in vivo and GeCKO screening to inactivate arbitrary genes, Alk, Bclaf3 and Prkra have been identified as genes regulating stemness.
04 Feb 2021
Cells replicate their genetic material and divide into two identical clones to perpetuate life. Some cells pause in the process with a single, undivided nucleus. When the cell resumes division after such a pause, the nucleus can become caught in the fissure, splitting violently, and killing both cells. But that is not always the case. Researchers from Hiroshima University in Japan are starting to understand how active nuclear displacement rescues cell death.
24 Jan 2021
Researchers at Kanazawa University report in Clinical Cancer Research that in the most common type of lung cancer, certain secondary mutations occurring with another gene alteration known as ALK make the efficacy of alectinib, an otherwise commonly used drug for treating lung cancer, become unfavorable. Combining alectinib with another kind of drug can overcome this adverse effect, however.
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Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields
Prof. Jinsoo Seo's research focuses on mechanisms of cellular dysfunction and cognitive decline in aging brain, genetic risk factors for neurodegeneration as well as the effect of environmental factors and lifestyle on Alzheimer's disease.
Babita Madan is an assistant professor at the Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.
David Virshup, M.D., is Director of the Programme in Cancer and Stem Cell Biology (CSCB) and Professor at Duke-NUS Medical School and is jointly appointed as Professor of Pediatrics at Duke University in North Carolina.
The prospect of favorably influencing brain health through dietary habits has gained much interest. My research interest explores the therapeutic potential of functional foods and phytonutrients as neuroprotectants against mitochondrial diseases and cerebral toxoplasmosis. The scientific findings support nutritional intervention as a viable strategy for the management of human brain disorders.
My research background covers multidisciplinary fields such as Pharmaceutics, Cancer Nanomedicine, Bioengineering and Organ-on-a-chip platforms. My current research focuses on the development of dynamic biological barriers on a chip such as blinking human cornea on a chip.
Professor Ahmed Al-Haddad, M.Sc., Ph.D. (Germany) is currently Professor of Microbiology and Medical Microbiology at College of Medicine and Health Sciences, Hadhramout University-Yemen. He is the Founding-Dean of the first Faculty of Nursing in Yemen. He has over fifteen years of research and teaching experience in various domains of life sciences. Al-Haddad has published many peer reviewed articles and conference papers in the areas of molecular biology, microbiology and antibiotics in National and International journals. He is reviewer in different national and international Scientific Journals such as Annals of Clinical Microbiology and Antimicrobials, Journal of Microbiology and Antimicrobials, Sultan Qaboos University Medical Journal, British Biotechnology Journal. He is a member of various national and international scientific organizations.