Biology Cell biology

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When researchers inhibited Wnt signalling the anti-cancer drug ETC-159, they found that the reactivation of the hyperactive RAS-MAPK pathway led the cancer cells to undergo senescence, which is an ageing process that results in arrested growth.
20 Nov 2020
Cancer is a disease driven by mutations that alter the way biochemical signals control cell growth, division and migration. Scientists at Duke-NUS Medical School found out that, like Goldilocks, cancer is very picky about getting rapid growth just right.
19 Nov 2020
A repetitive DNA sequence that causes health risks when it malfunctions can now be watched inside living cells using a synthetic tool
06 Nov 2020
Testing for mutations in RNF43, a protein that affects key cancer cell-growth pathway Wnt, gives clinicians actionable insights to tailor treatments better.
03 Nov 2020
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has proposed a new technique that controls the spatiotemporal resolution of Structured Illumination Microscopy (SIM) within a single image.
Lysosomes in a breast cancer cell.
29 Oct 2020
Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.
20 Oct 2020
Osaka City University detects cancer cells in 2ml blood samples and connects them back to their origin tumor – creating a new diagnostic tool that may aid in quicker and more accurate anti-cancer measures.
20 Oct 2020
Researchers at Kanazawa University and University of California, San Francisco report in Science that arbitrary proteins, when combined with anchoring and receptor proteins, can work as a signaling protein “morphogen” capable of engineered spatial patterning.
12 Oct 2020
Collaboration by researchers in Singapore and Australia lead to first-of-its-kind computational biology algorithm that could enable more effective cellular therapies against major diseases.
Image_iCeMS_Kamei_OpticsLetters
03 Oct 2020
A new apparatus improves how we study the effects of aiming high-field terahertz radiation at cells, with implications for regenerative medicine.
01 Oct 2020
Scientists have found an ingredient that makes a vaccine more effective through an approach more often seen in materials science – testing molecules that self-assemble into larger structures.
30 Sep 2020
Scientists have identified key molecules that mediate radioresistance in glioblastoma multiforme; these molecules are a potential target for the treatment of this brain cancer.
18 Sep 2020
Drugs tackling chronic myelogenous leukemia have completely transformed prognoses of patients over the last couple of decades, with most cases going into remission. But drug resistance can occur, leading to relapses. Targeting the lipids involved in regulating part of a leukemia stem cell’s life span offers a potential second route to defeat the disease—and solid tumorous cancers as well.
15 Sep 2020
A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.
Macrophage Activation Syndrome in COVID-19
08 Sep 2020
Scientists review macrophage activation syndrome — a feature of the cytokine storm that kills patients with severe cases of COVID-19, as well as possible treatments.
07 Sep 2020
Scientists are learning about species adaptation by comparing their stem cell-related genes.
04 Sep 2020
Pregnant mice fed diets high in omega-6 fats and low in omega-3 fats are shown in a new study to produce offspring whose brains had a higher level of dopamine-producing neurons—the neurological reward system. These mice went on to chase hyper-caloric diets, suggesting that the fats in a pregnant mother's diet may control the eating habits of her children, and potentially offering a new obesity-prevention strategy.
Hypothesis for mechanism of action of IL-34 in TNBC
21 Aug 2020
Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer.
06 Jul 2020
Researchers at Kanazawa University report in Biomaterials a high-speed atomic-force microscopy study of protein filaments in the nuclear pore complex. The visualization in real-time of the filaments’ dynamics is an important step in our understanding of molecular transport mechanisms between a cell nucleus and its surrounding medium.
iCeMS hasegawa malaria india
02 Jul 2020
A method that involves infecting liver cells with mosquito-bred parasites could improve the study of malaria in India.
20 Jun 2020
Researchers at Kanazawa University report in the Biophysical Journal that the process of cell removal from an epithelial layer follows from an inherent mechanical instability. Moreover, the forces generated by an extruding cell can drive the extrusion of other cells in a particular direction.
iCeMS glioma classification
03 Jun 2020
A highly accurate machine learning tool could help doctors tailor individualized treatments for people with glioma brain tumours.
12 May 2020
In a recent study published in Molecular Cell, researchers at Kanazawa University report the role of cellular structures called PML bodies in regulating gene function
16 Apr 2020
A small mitochondrial protein is necessary for energy production and its malfunction could be behind a range of degenerative diseases, according to study by Duke-NUS Medical School and their collaborators.
01 Apr 2020
A research team led by Professor Kin-ming KWAN from the School of Life Sciences at The Chinese University of Hong Kong (CUHK) has recently discovered a novel mechanism by which extrinsic signaling factors modulate the fate transition of neural progenitors to allow the generation of specific neuronal subtypes. This work provides important insight into stem cell biology and the regeneration of neuronal cells, and contributes to the development of neurological therapy for diseases like autism spectrum disorders and hereditary cerebellar ataxia. The research is published in the renowned international scientific journal Cell Reports.
26 Mar 2020
In a recent study published in Autophagy, researchers at Kanazawa University show how abnormalities in a gene called TPR can lead to pediatric brain cancer
Eye blinking on-a-chip image
24 Mar 2020
A new approach could lead to “cornea-on-a-chip” devices that more accurately test the effects of drugs on the human eye.
19 Mar 2020
Environmental changes trigger tiny RNA segments to modify plant pores involved in photosynthesis.
28 Feb 2020
A new compound with the potential to turn genes on and off could lead to new cancer and hereditary disease treatment strategies.
23 Dec 2019
NUS researchers found that chevron patterns in fish swimming muscles require physical forces to correctly develop, not only from genetic instruction or biochemical pathways.
A research team, led by Prof June M. Kwak
06 Dec 2019
Scientists in Korea find a protein that mediates the interaction between the cellular systems involved in rapid responses against foreign genes in plants

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Researchers

My research background covers multidisciplinary fields such as Pharmaceutics, Cancer Nanomedicine, Bioengineering and Organ-on-a-chip platforms. My current research focuses on the development of dynamic biological barriers on a chip such as blinking human cornea on a chip.
Professor Ahmed Al-Haddad, M.Sc., Ph.D. (Germany) is currently Professor of Microbiology and Medical Microbiology at College of Medicine and Health Sciences, Hadhramout University-Yemen. He is the Founding-Dean of the first Faculty of Nursing in Yemen. He has over fifteen years of research and teaching experience in various domains of life sciences. Al-Haddad has published many peer reviewed articles and conference papers in the areas of molecular biology, microbiology and antibiotics in National and International journals. He is reviewer in different national and international Scientific Journals such as Annals of Clinical Microbiology and Antimicrobials, Journal of Microbiology and Antimicrobials, Sultan Qaboos University Medical Journal, British Biotechnology Journal. He is a member of various national and international scientific organizations.
Toru Kondo is Professor of the Division of Stem Cell Biology at the Institute for Genetic Medicine, Hokkaido University.