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Genomics: Sequencing brain cancer (AOP)
DOI: 10.1038/nature07385
One of the richest and most comprehensive analyses so far of cancer samples is reported online this week in Nature. The Cancer Genome Atlas pilot project describes nucleotide sequence, DNA copy number, gene expression and DNA methylation alterations in the brain cancer glioblastoma, currently in the public eye following the diagnosis of Senator Ted Kennedy with the disease.
The consortium has, for example, found roles for three genes — ERBB2, NF1 and TP53 — in glioblastoma, discovered novel mutations in the kinase regulatory subunit gene PIK3R1, and provides a global view of the signalling pathways altered in the development of the cancer.
The research establishes the power of The Cancer Genome Atlas project and shows that it has the potential to expand rapidly our knowledge of the genetic alterations involved in cancers.
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Please note, two related papers are being published by the journal Science. Registered reporters can log onto http://www.eurekalert.org/jrnls/sci or contact AAAS at +1 202 326 6440, or [email protected].
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