PRESS RELEASE FROM CLINICAL PHARMACOLOGY & THERAPEUTICS
(http://www.nature.com/clpt)
This press release is copyrighted to Clinical Pharmacology & Therapeutics.
PLEASE CITE CLINICAL PHARMACOLOGY & THERAPEUTICS AND THE CLINICAL PHARMACOLOGY & THERAPEUTICS WEBSITE AS THE SOURCE OF THE FOLLOWING ITEM. IF PUBLISHING ONLINE, PLEASE CARRY A HYPERLINK TO www.nature.com/clpt/
A PDF of the paper mentioned on this release can be found in the Academic Journals section of http://press.nature.com. Press contacts for the Nature Publishing Group journals are listed at the end of this release.
Adolescents are overlooked in clinical trials
DOI: 10.1038/clpt.2008.191
To avoid unpredictable pharmacological responses among adolescents, this population should be more actively recruited into clinical trials, according to a new Commentary in Clinical Pharmacology & Therapeutics.
In addition to physical changes, adolescents are susceptible to psychosocial factors that can affect taking the drug as directed, and place them at risk for additional disorders. Mood disorders experienced by adolescents, as well as their reactions to marketing campaigns and incentives can also affect adherence to medications. Bill G. Kapogiannis and Donald R Mattison explore how adolescents are considered during drug development. They focus on the influence of inherent psychosocial, biological, ethical and regulatory issues on their recruitment and participation in clinical studies leading to drug licensing. Using the aggressive marketing campaign of Gardasil, a vaccine against human papillomavirus, as an example, the authors argue that marketing of such important drugs should be planned more carefully to encourage support from key stakeholders.
The Commentary appears in a special adolescent pharmacology themed issue, organized by guest editor Dr. Gregory Kearns. A web focus on the topic of Adolescent Medicine, containing a variety of free articles from Nature Publishing Group publications, is also available at http://www.nature.com/clpt/webfocus/adolescentmed
Author contact:
Bill G Kapogiannis (National Institute of Child Health and Human Development, Bethesda, MD, USA)
Tel: +1 301 402 0698; E-mail: [email protected]
Media contacts:
Ruth Francis (Head of Press, Nature London)
Tel: +44 20 7843 4562; E-mail: [email protected]
About NPG
Nature Publishing Group (NPG) is a division of Macmillan Publishers Ltd, dedicated to serving the academic, professional scientific and medical communities. NPG's flagship title, Nature, was first published in 1869. Other publications include Nature research journals, Nature Reviews, Nature Clinical Practice and a range of prestigious academic journals including society-owned publications. NPG also provides news content through Nature News. Scientific career information and free job postings are offered on Naturejobs.
NPG is a global company with headquarters in London and offices in New York, San Francisco, Washington DC, Boston, Tokyo, Paris, Madrid, Munich, Hong Kong, Melbourne, Delhi, Mexico City and Basingstoke. For more information, please go to www.nature.com.
