Bone

The pursuit of an improved quality of life by people with increasing requirements means that conventional technology with single and standardised measurements no longer meets consumer demand. The fabrication of personalised clothes and footwear is one of the important factors that has led to the development in smart living. Prof. Charlie C.L. Wang from the Department of Mechanical and Automation Engineering of The Chinese University of Hong Kong (CUHK) and his team have pioneered Shape Driven Technology. After further improvement and development, it is now equipped with the mature fast scanning, the big-data driven artificial intelligence and the digital knitting technology to achieve its mission of automatically fabricating personalised clothes and footwear according to individual forms. In the future, consumers will be able to place orders directly with manufacturers to fabricate customised wearable products in all kinds of styles, quickly and easily. It will take the operation mode of the manufacturing industry into a great leap towards realising the upgrade to Industry 4.0 (I4.0) / smart manufacturing. This project recently won the Silver Award in the 47th Geneva International Invention Exhibition.

A research team from the School of Chinese Medicine at Hong Kong Baptist University (HKBU) has successfully developed a novel aptamer, i.e. a single-stranded piece of DNA, for the treatment of osteogenesis imperfecta (OI) with the aid of artificial intelligence (AI) technology. It is the first time a drug in Hong Kong has been granted orphan drug designation by the US Food and Drug Administration (FDA).

A new scaffold expands to fill in bone defects and encourage tissue growth.

Turning off a bone receptor protein could potentially treat osteoporosis in children without affecting bone growth.

Japanese scientists have revealed a biological “switch” that influences whether an immature blood cell would develop into a red blood cell or a subtype of white blood cell called myeloid cells in response to infection or inflammation within the body.

Researchers from The Hong Kong Polytechnic University (PolyU) have designed and fabricated a high performing self-fitting bone scaffold by combining a shape memory foam and hydroxyapatite (the principal mineral component of bone tissue).

Korean researchers identified a mechanism for signaling brain nerve cells through excitatory synaptic binding proteins. The finding provides important clues to understanding the principles of synaptic nerve transmission and thus can be used to analyze the fundamental causes of brain diseases and treat them.

Researchers have identified a treatment for a rare bone loss disorder that might also lead to help for aging brittle bones.

The protein CD34 is predominantly regarded as a marker of blood-forming stem cells but it helps with migration to the bone marrow too.

Professor Jeong Beom Kim, founder of SuPine Therapeutics Co., Ltd. at South Korea's Ulsan National Institute of Science and Technology (UNIST) has been selected to receive an award from the Korean Ministry of SMEs and Startups.

Imagine being able to take cells from your skin, transform them into other types of cells, such as lung, brain, heart or muscle cells, and use those to cure your ailments, from diabetes to heart disease or macular degeneration. To realise this, however, challenges still remain, Professor Janet Rossant, a pioneer in the field, says.

In a recent study published in Electrophoresis, University of Malaya’s researchers found significant correlation between increased levels of serum amyloid A (SAA) in patients with three different bone sarcomas: pleomorphic sarcoma (PS), osteosarcoma (OS) and chondrosarcoma (CS) and the different degrees of tumor malignancy in PS, OS and CS.

Refining the purification process of therapeutic cells could improve their use for treating cancer and other diseases.

Prolonged prenatal ultrasound exposure leads to decreased bone density and strength in young rabbits.

Scissor-like structured platform for vibration suppression.

Researchers at Nagoya University establish a new index based on rib strength measurement, which can use fossil records to predict whether extinct mammalian species lived exclusively in the water, were occasionally on land, or were fully land-based.

Malaysian scientists have provided evidence that a widely used chemical is more toxic to certain blood cell precursors in the bone marrow than to others.

Researchers are excavating human remains from caves in Palawan Island in the Philippines to learn more about the diversity of burial and other cultural practices over the past 10,000 years.

Researchers in Japan have shown that modified gold nanoparticles can be used to control the differentiation of stem cells into bone.

Nagoya University-based researchers analyze ancient DNA of Neolithic domestic goats to reveal that the goats were introduced into the Southern Caucasus from the Fertile Crescent during the early sixth millennium BC, probably alongside establishment of trade links or population movement.

Researchers from Hong Kong and the U.S. have developed a new statistical and mapping method that could help identify drug targets for treating leukaemia.

A biochemical compound developed as a radioactive tracer for cell proliferation shows increasing potential for use in cancer imaging, according to a recent paper published in the Pertanika Journal of Science & Technology.

Study suggests dengue can persist year-round in China, increasing the risk of more frequent and severe outbreaks

Researchers in Singapore, for the first time, have recreated two key processes essential for fetal formation in vitro. The team has not only controlled the differentiation of stem cells into other cell types, but they have also demonstrated the successful migration of these transformed cells.

A prototype camera, which uses gamma ray detection to pinpoint breast cancer lesions in three dimensions, promises to extend the useful life of two-dimensional nuclear imaging devices in developing countries.

Surface Modification by Carboxyl Groups Suppressing Osteogenic Differentiation. Nanomaterials Paving the Way for Regenerative Medicine

Singapore 13 April, 2015 - Thermo Fisher Scientific Inc., the world leader in serving science, and the National University of Singapore (NUS) on 13 April announced three research projects, which are supported under their strategic alliance. Each project could receive a grant of up to S$300,000 per year.

On 15 October 2014, in conjunction with the visit of IFOM Scientific Director Prof. Marco Foiani to Singapore, a mini-symposium was held at the Mechanobiology Institute, National University of Singapore. A reception to celebrate the IFOM-MBI partnership was held at the end of the mini-symposium.

New technique that identifies rare stem cells from bone marrow will give clinicians a fillip in stem-cell treatment of joint, bone and muscle repair.

A major success in developing new biomedical implants with the ability to accelerate bone healing has been reported by a group of scientists from the Department of Restorative Dentistry, University of Malaya. This stems from a project partly funded by HIR and also involves Mr. Alireza Yaghoubi, HIR Young Scientist.